Ageing and dysregulated lung immune responses in fatal COVID-19

• Published in: Immunity & ageing Vol. 22; no. 1; pp. 32 - 12
• Main Authors: de Souza Xavier Costa, Natália, de Brito, Jôse Mara, Froio, Carla, Ribeiro Júnior, Gabriel, Lamounier, Ana Carolina Alves, Antonangelo, Leila, Faria, Caroline Silvério, Ito, Juliana Tiyaki, Santos Lopes, Fernanda Degobbi Tenorio Quirino do, de Almeida Monteiro, Renata Aparecida, Duarte-Neto, Amaro Nunes, Saldiva, Paulo Hilário Nascimento, Ferraz da Silva, Luiz Fernando, Dolhnikoff, Marisa, Mauad, Thais
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.07.2025; BioMed Central; BMC
• Subjects: Age; Aging; Analysis; Autopsies; Autopsy; B cells; Body mass index; CD20 antigen; CD8 antigen; Cell density; Chemokines; Comorbidity; COVID-19; Cytokines; Demographics; Epidemics; Geriatrics; GTP-binding protein; Immune response; Immunohistochemistry; Immunopathology; Infections; Inflammation; Lung diseases; Lung inflammation; Lungs; Lymphocytes T; Medical research; Medicine, Experimental; p53 Protein; Parenchyma; Pathology; Protein expression; Proteins; Senescence; Severe acute respiratory syndrome coronavirus 2; Software; T cells; TLR7 protein; Toll-like receptors; Transforming growth factors; Tumor proteins; Ventilators; United States > US; COVID-19; Immunopathology; Senescence; Lung inflammation; Autopsy

Elderly individuals were disproportionally affected during the COVID-19 pandemic, and more than 80% of the global COVID-19-related deaths between 2020 and 2021 occurred among people aged 60 years or older. Several cellular modifications in aged cells may lead to systemic inflammation and fibrotic re...