Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease

• Published in: Current biology Vol. 31; no. 14; pp. 3028 - 3039.e7
• Main Authors: Shen, James L., Fortier, Tina M., Zhao, Yan G., Wang, Ruoxi, Burmeister, Margit, Baehrecke, Eric H.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 26.07.2021
• Subjects: autophagy; Autophagy - genetics; Drosophila; Endoplasmic Reticulum - metabolism; GTP Phosphohydrolases - metabolism; Humans; membrane contact; Membrane Proteins - genetics; Membrane Proteins - metabolism; mitochondria; Mitochondria - metabolism; Mitochondrial Dynamics - genetics; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Mitochondrial Size; Proteins - metabolism; Vmp1; Vps13D; Vmp1; membrane contact; Vps13D; autophagy; mitochondria; Drosophila

Mutations in Vps13D cause defects in autophagy, clearance of mitochondria, and human movement disorders. Here, we discover that Vps13D functions in a pathway downstream of Vmp1 and upstream of Marf/Mfn2. Like vps13d, vmp1 mutant cells exhibit defects in autophagy, mitochondrial size, and clearance....