Reduction of lithium induced interstitial fibrosis on co-administration with amiloride

• Published in: Scientific reports Vol. 12; no. 1; pp. 14598 - 15
• Main Authors: Mehta, Paulomi M., Gimenez, Gregory, Walker, Robert J., Slatter, Tania L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.08.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4022; 692/420; 692/699; 692/699/1585/104; 692/699/1585/2760; 692/699/1585/3182; Amiloride; CD3 antigen; Epithelial cells; Fibrosis; Gene expression; Humanities and Social Sciences; Immunohistochemistry; Inflammation; Kidneys; Lithium; miRNA; multidisciplinary; NF-κB protein; p53 Protein; Pericytes; Science; Science (multidisciplinary)

Long-term administration of lithium is associated with chronic interstitial fibrosis that is partially reduced with exposure to amiloride. We examined potential pathways of how amiloride may reduce interstitial fibrosis. Amiloride was administered to a rat model of lithium induced interstitial fibro...