Pathogenesis and clinical management of obesity-related knee osteoarthritis: Impact of mechanical loading

• Published in: Journal of orthopaedic translation Vol. 24; pp. 66 - 75
• Main Authors: Chen, Lianzhi, Zheng, Jessica Jun Yi, Li, Guangyi, Yuan, Jun, Ebert, Jay R., Li, Hengyuan, Papadimitriou, John, Wang, Qingwen, Wood, David, Jones, Christopher W., Zheng, Minghao
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier (Singapore) Pte Ltd 01.09.2020; Chinese Speaking Orthopaedic Society; Elsevier
• Subjects: Biomechanics; Clinical management; Mechanical loading; Obesity; Osteoarthritis; Pathogenesis; Review; Biomechanics; Obesity; Clinical management; Mechanical loading; Pathogenesis; Osteoarthritis

Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients’ quality of life. Whilst chronic inflammation, adipocytokines and metabolic factors are considered to be important pathogenic factors in obesity related OA, there has been limited...