Pathogenesis and clinical management of obesity-related knee osteoarthritis: Impact of mechanical loading

Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients’ quality of life. Whilst chronic inflammation, adipocytokines and metabolic factors are considered to be important pathogenic factors in obesity related OA, there has been limited...

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Published inJournal of orthopaedic translation Vol. 24; pp. 66 - 75
Main Authors Chen, Lianzhi, Zheng, Jessica Jun Yi, Li, Guangyi, Yuan, Jun, Ebert, Jay R., Li, Hengyuan, Papadimitriou, John, Wang, Qingwen, Wood, David, Jones, Christopher W., Zheng, Minghao
Format Journal Article
LanguageEnglish
Published Singapore Elsevier (Singapore) Pte Ltd 01.09.2020
Chinese Speaking Orthopaedic Society
Elsevier
Subjects
Biomechanics
Clinical management
Mechanical loading
Obesity
Osteoarthritis
Pathogenesis
Review
Biomechanics
Obesity
Clinical management
Mechanical loading
Pathogenesis
Osteoarthritis
Online AccessGet full text

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Abstract Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients’ quality of life. Whilst chronic inflammation, adipocytokines and metabolic factors are considered to be important pathogenic factors in obesity related OA, there has been limited investigation into the biomechanical impact of obesity on OA development. This review aims to demonstrate that mechanical factors are the major pathological cause of obesity-related OA. The effect of obesity on pathological changes to the osteochondral unit and surrounding connective tissues in OA is summarized, as well as the impact of obesity-related excessive and abnormal joint loading, concomitant joint malalignment and muscle weakness. An integrated therapeutic strategy based on this multi-factorial presentation is presented, to assist in the management of obesity related OA. Despite the high prevalence of obesity-related OA, there is no specific guideline available for obesity-related OA management. In this review, we demonstrated the pathological changes of obesity-related OA and summarized the impact of biomechanical factors by proposing a hypothetical model of obesity-related OA change. Therapeutic strategies based on adjusting abnormal mechanical effects are presented to assist in the management of obesity-related OA.
AbstractList Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients' quality of life. Whilst chronic inflammation, adipocytokines and metabolic factors are considered to be important pathogenic factors in obesity related OA, there has been limited investigation into the biomechanical impact of obesity on OA development. This review aims to demonstrate that mechanical factors are the major pathological cause of obesity-related OA. The effect of obesity on pathological changes to the osteochondral unit and surrounding connective tissues in OA is summarized, as well as the impact of obesity-related excessive and abnormal joint loading, concomitant joint malalignment and muscle weakness. An integrated therapeutic strategy based on this multi-factorial presentation is presented, to assist in the management of obesity related OA. Despite the high prevalence of obesity-related OA, there is no specific guideline available for obesity-related OA management. In this review, we demonstrated the pathological changes of obesity-related OA and summarized the impact of biomechanical factors by proposing a hypothetical model of obesity-related OA change. Therapeutic strategies based on adjusting abnormal mechanical effects are presented to assist in the management of obesity-related OA.
Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients' quality of life. Whilst chronic inflammation, adipocytokines and metabolic factors are considered to be important pathogenic factors in obesity related OA, there has been limited investigation into the biomechanical impact of obesity on OA development. This review aims to demonstrate that mechanical factors are the major pathological cause of obesity-related OA. The effect of obesity on pathological changes to the osteochondral unit and surrounding connective tissues in OA is summarized, as well as the impact of obesity-related excessive and abnormal joint loading, concomitant joint malalignment and muscle weakness. An integrated therapeutic strategy based on this multi-factorial presentation is presented, to assist in the management of obesity related OA.Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients' quality of life. Whilst chronic inflammation, adipocytokines and metabolic factors are considered to be important pathogenic factors in obesity related OA, there has been limited investigation into the biomechanical impact of obesity on OA development. This review aims to demonstrate that mechanical factors are the major pathological cause of obesity-related OA. The effect of obesity on pathological changes to the osteochondral unit and surrounding connective tissues in OA is summarized, as well as the impact of obesity-related excessive and abnormal joint loading, concomitant joint malalignment and muscle weakness. An integrated therapeutic strategy based on this multi-factorial presentation is presented, to assist in the management of obesity related OA.Despite the high prevalence of obesity-related OA, there is no specific guideline available for obesity-related OA management. In this review, we demonstrated the pathological changes of obesity-related OA and summarized the impact of biomechanical factors by proposing a hypothetical model of obesity-related OA change. Therapeutic strategies based on adjusting abnormal mechanical effects are presented to assist in the management of obesity-related OA.THE TRANSLATIONAL POTENTIAL OF THIS ARTICLEDespite the high prevalence of obesity-related OA, there is no specific guideline available for obesity-related OA management. In this review, we demonstrated the pathological changes of obesity-related OA and summarized the impact of biomechanical factors by proposing a hypothetical model of obesity-related OA change. Therapeutic strategies based on adjusting abnormal mechanical effects are presented to assist in the management of obesity-related OA.
Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients’ quality of life. Whilst chronic inflammation, adipocytokines and metabolic factors are considered to be important pathogenic factors in obesity related OA, there has been limited investigation into the biomechanical impact of obesity on OA development. This review aims to demonstrate that mechanical factors are the major pathological cause of obesity-related OA. The effect of obesity on pathological changes to the osteochondral unit and surrounding connective tissues in OA is summarized, as well as the impact of obesity-related excessive and abnormal joint loading, concomitant joint malalignment and muscle weakness. An integrated therapeutic strategy based on this multi-factorial presentation is presented, to assist in the management of obesity related OA. The translational potential of this article: Despite the high prevalence of obesity-related OA, there is no specific guideline available for obesity-related OA management. In this review, we demonstrated the pathological changes of obesity-related OA and summarized the impact of biomechanical factors by proposing a hypothetical model of obesity-related OA change. Therapeutic strategies based on adjusting abnormal mechanical effects are presented to assist in the management of obesity-related OA.
Author Zheng, Jessica Jun Yi
Papadimitriou, John
Li, Guangyi
Zheng, Minghao
Chen, Lianzhi
Yuan, Jun
Jones, Christopher W.
Wood, David
Ebert, Jay R.
Li, Hengyuan
Wang, Qingwen
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  organization: Centre for Orthopaedic Research, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia
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  givenname: Jessica Jun Yi
  surname: Zheng
  fullname: Zheng, Jessica Jun Yi
  organization: Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
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  givenname: Guangyi
  surname: Li
  fullname: Li, Guangyi
  organization: Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
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  orcidid: 0000-0001-6542-4654
  surname: Yuan
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  surname: Ebert
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  fullname: Li, Hengyuan
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  givenname: Qingwen
  surname: Wang
  fullname: Wang, Qingwen
  organization: Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
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  givenname: David
  surname: Wood
  fullname: Wood, David
  organization: Centre for Orthopaedic Research, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia
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  givenname: Christopher W.
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  givenname: Minghao
  orcidid: 0000-0003-1185-4768
  surname: Zheng
  fullname: Zheng, Minghao
  email: minghao.zheng@uwa.edu.au
  organization: Centre for Orthopaedic Research, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32695606$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1136/ard.2006.059931
10.1589/jpts.29.461
10.1136/ard.2010.142364
10.1371/journal.pone.0227975
10.2106/00004623-200612000-00012
10.1038/nrrheum.2012.69
10.1016/j.joca.2010.04.006
10.1016/j.jcot.2018.09.004
10.1002/art.40102
10.1016/j.clinbiomech.2015.09.017
10.1093/rheumatology/keu141
10.1136/ard.2006.065904
10.1136/ard.2010.144725
10.1136/annrheumdis-2020-216942
10.1016/S2213-8587(14)70034-8
10.1136/ard.2008.093229
10.1002/art.37696
10.1136/ard.2010.134015
10.1002/jor.1100020303
10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E
10.1136/ard.2003.011742
10.1016/j.arth.2013.02.036
10.1093/ajcn/72.3.690
10.1016/j.joca.2012.10.014
10.1186/s13075-016-0953-x
10.1016/S0140-6736(72)90179-1
10.1136/bmj.b3170
10.1186/ar4405
10.1002/art.39460
10.1038/nrrheum.2015.135
10.3810/psm.2011.11.1938
10.1002/acr.22504
10.1016/j.actbio.2012.07.042
10.1002/acr.22854
10.1093/ajcn/82.4.872
10.1002/jor.22809
10.1016/j.joca.2017.11.015
10.1016/j.jmbbm.2016.09.040
10.1016/j.jbiomech.2017.09.020
10.1136/annrheumdis-2013-205012
10.1038/nrrheum.2010.198
10.1177/03635465020300031801
10.1053/jars.2002.35258
10.1002/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9
10.1007/s11999-013-3297-8
10.1097/00002142-199906000-00002
10.1016/j.joca.2017.09.003
10.1002/art.38375
10.1136/annrheumdis-2012-202745
10.1016/j.joca.2019.04.017
10.1002/jor.20027
10.1002/art.38965
10.1136/ard.2009.118182
10.1136/ard.2010.147082
10.1016/j.joca.2014.01.003
10.1016/j.joca.2019.01.018
10.1136/ard.2010.142018
10.1136/bmjopen-2013-003614
10.1186/s12891-015-0737-5
10.1136/ard.61.7.617
10.1249/MSS.0b013e31816a85ce
10.1136/ard.2006.058347
10.1002/jor.1100180202
10.1002/bdrc.21092
10.1016/j.knee.2018.06.017
10.1016/j.joca.2015.03.034
10.1016/j.joca.2018.03.003
10.1097/01.bor.0000240366.54960.a1
10.1016/j.joca.2005.07.014
10.1038/ijo.2009.62
10.1002/acr.20476
10.1093/rheumatology/kep246
10.1038/ijo.2012.221
10.1016/j.joca.2018.08.006
10.1016/j.joca.2014.05.013
10.1016/j.joca.2013.08.006
10.1016/j.arth.2006.02.099
10.1007/s11999-016-4791-6
10.1007/s00167-014-3068-4
10.2106/00004623-200711000-00009
10.1016/j.joca.2006.02.004
10.1038/s41598-017-03759-w
10.1002/art.22245
10.1136/ard.2006.053538
10.1016/j.bone.2018.01.012
10.1016/j.joca.2017.03.014
10.1053/apmr.2002.33988
10.1002/jor.23204
10.1136/annrheumdis-2014-206376
10.1002/art.20726
10.7326/0003-4819-134-7-200104030-00007
10.1007/s00167-011-1818-0
10.1097/PHM.0b013e318206386b
10.1016/j.joca.2016.01.984
10.1016/S1047-8477(02)00635-4
10.1177/0363546514565092
10.1002/art.40692
10.1002/jor.23459
10.2522/ptj.20080079
10.1038/oby.2005.47
10.1001/jama.2013.277669
10.1016/j.joca.2012.09.012
10.1016/j.joca.2005.08.013
10.1016/j.joca.2007.04.010
10.1148/radiol.2017161005
10.1002/art.37906
10.1002/art.23560
10.1016/j.pathophys.2015.06.001
10.1016/j.joca.2016.12.001
10.1001/jama.2017.5283
10.1001/jamainternmed.2015.0461
10.1016/j.bone.2011.10.010
10.1002/art.21139
10.1002/art.38062
10.1002/jor.21077
10.1177/0363546510377445
10.1136/bmjopen-2017-017689
10.1016/S0889-857X(03)00061-9
10.1016/j.joca.2014.03.003
10.1038/s41574-018-0062-9
10.1038/nrrheum.2016.148
10.1016/j.bone.2012.02.012
10.7326/0003-4819-138-8-200304150-00006
10.1002/art.24021
10.5435/JAAOS-D-16-00541
10.1136/ard.2011.150052
10.1097/PHM.0b013e318198b51b
10.1016/j.bone.2019.03.011
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Keywords Biomechanics
Obesity
Clinical management
Mechanical loading
Pathogenesis
Osteoarthritis
Language English
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References Visser, de Mutsert, le Cessie, den Heijer, Rosendaal, Kloppenburg (bib7) 2015; 74
Rodrigues, Ferreira, Pereira, Bonfa, Borba, Fuller (bib121) 2008; 59
Draganich, Reider, Rimington, Piotrowski, Mallik, Nasson (bib112) 2006; 88
Radin, Paul, Rose (bib69) 1972; 1
Ebert, Hambly, Joss, Ackland, Donnelly (bib115) 2014; 472
Mikesky, Meyer, Thompson (bib76) 2000; 18
Harasymowicz, Clement, Azfer, Burnett, Salter, Simpson (bib18) 2017; 69
Reina, Cavaignac, Pailhe, Pailliser, Bonnevialle, Swider (bib15) 2017; 35
Zarka, Hay, Ostertag, Marty, Chappard, Oudet (bib32) 2019; 123
Bliddal, Leeds, Stigsgaard, Astrup, Christensen (bib88) 2011; 70
Brandt, Radin, Dieppe, van de Putte (bib72) 2006; 65
Wang, Hunter, Jin, Ding (bib39) 2018; 26
Robbins, Birmingham, Callaghan, Jones, Chesworth, Maly (bib64) 2011; 63
Di Luca, Van Blitterswijk, Moroni (bib27) 2015; 105
Campbell, Ferguson, Hurley (bib101) 2012; 8
Vanwanseele, Eckstein, Smith, Lange, Foroughi, Baker (bib63) 2010; 18
Jafarzadeh, Clancy, Li, Apovian, Guermazi, Eckstein (bib91) 2018; 26
Jansen, Mastbergen, van Heerwaarden, Spruijt, van Empelen, Kester (bib124) 2020; 15
Mauricio, Sliepen, Rosenbaum (bib120) 2018; 25
Dorleijn, Luijsterburg, Reijman, Kloppenburg, Verhaar, Bindels (bib4) 2018; 77
Wiegant, van Roermund, Intema, Cotofana, Eckstein, Mastbergen (bib123) 2013; 21
Wu, Holguin, Silva, Fu, Liao, Sandell (bib54) 2014; 66
Pozzobon, Ferreira, Blyth, Machado, Ferreira (bib130) 2018; 8
Henriksen, Christensen, Hunter, Gudbergsen, Boesen, Lohmander (bib90) 2014; 22
Heinegard, Saxne (bib21) 2011; 7
Muratovic, Cicuttini, Wluka, Findlay, Wang, Otto (bib35) 2015; 18
Widmyer, Utturkar, Leddy, Coleman, Spritzer, Moorman (bib25) 2013; 65
Ding, Cicuttini, Scott, Cooley, Jones (bib24) 2005; 13
Goldring, Goldring (bib20) 2016; 12
Matzkin, Curry, Kong, Rogers, Henry, Smith (bib8) 2017; 25
Widhalm, Seemann, Hamboeck, Mittlboeck, Neuhold, Friedrich (bib13) 2016; 24
Scanzello, Goldring (bib40) 2012; 51
Felson, Goggins, Niu, Zhang, Hunter (bib71) 2004; 50
Matheny, Goff, Pownder, Koff, Hayashi, Yang (bib38) 2017; 64
Ramsey, Briem, Axe, Snyder-Mackler (bib113) 2007; 89
Lafeber, Intema, Van Roermund, Marijnissen (bib122) 2006; 18
Radin, Martin, Burr, Caterson, Boyd, Goodwin (bib57) 1984; 2
Coleman, Ramakrishnan, Brouillette, Martin (bib49) 2016; 68
Murphy, Schwartz, Helmick, Renner, Tudor, Koch (bib2) 2008; 59
McAlindon, LaValley, Harvey, Price, Driban, Zhang (bib5) 2017; 317
Kanamiya, Naito, Hara, Yoshimura (bib127) 2002; 18
Pearson, Herndler-Brandstetter, Tariq, Nicholson, Philp, Smith (bib43) 2017; 7
Schultz, DeBaun, Huddleston (bib132) 2019; 327
Hui, Salmon, Kok, Williams, Hockers, van der Tempel (bib126) 2010; 39
Misra, Fielding, Felson, Niu, Brown, Nevitt (bib83) 2019; 71
Richette, Poitou, Garnero, Vicaut, Bouillot, Lacorte (bib86) 2011; 70
Gersing, Solka, Joseph, Schwaiger, Heilmeier, Feuerriegel (bib95) 2016; 24
Englund, Felson, Guermazi, Roemer, Wang, Crema (bib19) 2011; 70
Intema, Van Roermund, Marijnissen, Cotofana, Eckstein, Castelein (bib125) 2011; 70
Heijink, Gomoll, Madry, Drobnič, Filardo, Espregueira-Mendes (bib66) 2012; 20
Felson (bib9) 2013; 21
Suri, Walsh (bib28) 2012; 51
Reijman, Pols, Bergink, Hazes, Belo, Lievense (bib67) 2007; 66
Christensen, Henriksen, Leeds, Gudbergsen, Christensen, Sorensen (bib89) 2015; 67
Pritzker, Gay, Jimenez, Ostergaard, Pelletier, Revell (bib22) 2006; 14
Zizak, Roschger, Paris, Misof, Berzlanovich, Bernstorff (bib30) 2003; 141
van Caam, Thijssen, van der Kraan (bib12) 2014; 54
de Lange-Brokaar, Ioan-Facsinay, Yusuf, Visser, Kroon, van Osch (bib41) 2015; 67
Arno, Bell, Uquillas, Borukhov, Walker (bib56) 2015; 33
Li, Yin, Gao, Cheng, Pavlos, Zhang (bib1) 2013; 15
Englund, Roemer, Hayashi, Crema, Guermazi (bib44) 2012; 8
Jenkinson, Doherty, Avery, Read, Taylor, Sach (bib94) 2009; 339
Chen, Yao, Wang, Li, Chen, Bulsara (bib10) 2020
Imhof, Breitenseher, Kainberger, Rand, Trattnig (bib29) 1999; 10
van der Voet, Runhaar, van der Plas, Vroegindeweij, Oei, Bierma-Zeinstra (bib46) 2017; 25
Hilton, Tuttle, Bohnert, Mueller, Sinacore (bib80) 2008; 88
Erhart, Mündermann, Elspas, Giori, Andriacchi (bib117) 2010; 28
Topp, Woolley, Hornyak, Khuder, Kahaleh (bib106) 2002; 83
Batsis, Villareal (bib81) 2018; 14
Segal, Glass (bib73) 2011; 39
Muratovic, Findlay, Cicuttini, Wluka, Lee, Kuliwaba (bib16) 2018; 108
Roos, Arden (bib105) 2016; 12
Segal, Yack, Khole (bib60) 2009; 88
Sharma, Chang (bib68) 2007; 66
Pollo, Otis, Backus, Warren, Wickiewicz (bib114) 2002; 30
Guymer, Baranyay, Wluka, Hanna, Bell, Davis (bib31) 2007; 15
Newman, Lee, Visser, Goodpaster, Kritchevsky, Tylavsky (bib103) 2005; 82
Sharma, Dunlop, Cahue, Song, Hayes (bib108) 2003; 138
Felson, Chaisson, Hill, Totterman, Gale, Skinner (bib36) 2001; 134
Runhaar, de Vos, van Middelkoop, Vroegindeweij, Oei, Bierma-Zeinstra (bib87) 2016; 68
Odum, Springer, Dennos, Fehring (bib3) 2013; 28
Hunter, Beavers, Eckstein, Guermazi, Loeser, Nicklas (bib93) 2015; 23
Practitioners RACoG (bib11) 2018
Santos, Emery, Neu, Pierce (bib53) 2019; 27
Mikesky, Mazzuca, Brandt, Perkins, Damush, Lane (bib107) 2006; 55
Slemenda, Heilman, Brandt, Katz, Mazzuca, Braunstein (bib79) 1998; 41
Frimel, Sinacore, Villareal (bib104) 2008; 40
Wortsman, Matsuoka, Chen, Lu, Holick (bib34) 2000; 72
Lee, Kim, Kim (bib82) 2012; 64
Wilson, van Burken, van Donkelaar, Buma, van Rietbergen, Huiskes (bib55) 2006; 24
Callaghan, Parkes, Hutchinson, Gait, Forsythe, Marjanovic (bib109) 2015; 74
Roemhildt, Beynnon, Gauthier, Gardner-Morse, Ertem, Badger (bib48) 2013; 21
Zhang, Bierma-Zeinstra, Oei, Turkiewicz, Englund, Runhaar (bib45) 2017; 25
Ko, Dragomir, Plumb, Hsia, Adebayo, Goldring (bib52) 2016; 34
Landsmeer, de Vos, van der Plas, van Middelkoop, Vroegindeweij, Bindels (bib42) 2018; 26
Anandacoomarasamy, Leibman, Smith, Caterson, Giuffre, Fransen (bib14) 2012; 71
Culliford, Maskell, Judge, Arden (bib131) 2013; 3
Jordan, Arden, Doherty, Bannwarth, Bijlsma, Dieppe (bib84) 2003; 62
Kalyani, Corriere, Ferrucci (bib77) 2014; 2
Beckwee, Vaes, Shahabpour, Muyldermans, Rommers, Bautmans (bib37) 2015; 43
Henriksen, Christensen, Klokker, Bartholdy, Bandak, Ellegaard (bib6) 2015; 175
Rai, Sandell, Cheverud, Brophy (bib47) 2013; 37
Bennell, Creaby, Wrigley, Bowles, Hinman, Cicuttini (bib62) 2010; 69
Messier, Mihalko, Legault, Miller, Nicklas, DeVita (bib100) 2013; 310
Parratte, Ollivier, Lunebourg, Verdier, Argenson (bib133) 2017; 475
Messier, Gutekunst, Davis, DeVita (bib85) 2005; 52
Cushnaghan, Bennett, Reading, Croft, Byng, Cox (bib129) 2009; 68
Harding, Dunbar, Hubley-Kozey, Stanish, Astephen Wilson (bib58) 2016; 31
Nakagawa, Maeda (bib74) 2017; 29
Messier, Mihalko, Legault, Miller, Nicklas, DeVita (bib92) 2013; 310
Burr, Radin (bib33) 2003; 29
Stenholm, Alley, Bandinelli, Griswold, Koskinen, Rantanen (bib78) 2009; 33
Christensen, Bartels, Astrup, Bliddal (bib98) 2007; 66
Messier, Pater, Beavers, Legault, Loeser, Hunter (bib59) 2014; 22
Miyazaki, Wada, Kawahara, Sato, Baba, Shimada (bib61) 2002; 61
Bennell, Bowles, Wang, Cicuttini, Davies-Tuck, Hinman (bib65) 2011; 70
Anandacoomarasamy, Smith, Leibman, Caterson, Giuffre, Fransen (bib23) 2009; 48
Raja, Dewan (bib119) 2011; 90
Ko, Dragomir, Plumb, Goldring, Wright, Goldring (bib51) 2013; 65
Tuhanioğlu, Oğur, Seyfettinoğlu, Çiçek, Gültekin (bib111) 2019; 10
van Outeren, Waarsing, Brouwer, Verhaar, Reijman, Bierma-Zeinstra (bib110) 2017; 25
Runhaar, van Middelkoop, Reijman, Vroegindeweij, Oei, Bierma-Zeinstra (bib70) 2014; 53
Brouwer, van Raaij, Verhaar, Coene, Bierma-Zeinstra (bib118) 2006; 14
Spahn, Kirschbaum, Kahl (bib128) 2006; 14
Gersing, Schwaiger, Nevitt, Zarnowski, Joseph, Feuerriegel (bib97) 2019; 27
Kaplan, Neu, Drissi, Emery, Pierce (bib50) 2017; 65
Fernandes, Hagen, Bijlsma, Andreassen, Christensen, Conaghan (bib99) 2013; 72
Gersing, Schwaiger, Nevitt, Joseph, Chanchek, Guimaraes (bib96) 2017; 284
McAlindon, Bannuru, Sullivan, Arden, Berenbaum, Bierma-Zeinstra (bib102) 2014; 22
Hart, Doyle, Spector (bib17) 1999; 42
Kaspiris, Khaldi, Chronopoulos, Vasiliadis, Grivas, Kouvaras (bib26) 2015; 22
Muraki, Akune, Teraguchi, Kagotani, Asai, Yoshida (bib75) 2015; 16
Dennis, Komistek, Nadaud, Mahfouz (bib116) 2006; 21
Suri (10.1016/j.jot.2020.05.001_bib28) 2012; 51
Intema (10.1016/j.jot.2020.05.001_bib125) 2011; 70
Rai (10.1016/j.jot.2020.05.001_bib47) 2013; 37
Fernandes (10.1016/j.jot.2020.05.001_bib99) 2013; 72
Raja (10.1016/j.jot.2020.05.001_bib119) 2011; 90
Newman (10.1016/j.jot.2020.05.001_bib103) 2005; 82
Pritzker (10.1016/j.jot.2020.05.001_bib22) 2006; 14
Imhof (10.1016/j.jot.2020.05.001_bib29) 1999; 10
Gersing (10.1016/j.jot.2020.05.001_bib95) 2016; 24
Matzkin (10.1016/j.jot.2020.05.001_bib8) 2017; 25
Lee (10.1016/j.jot.2020.05.001_bib82) 2012; 64
Heinegard (10.1016/j.jot.2020.05.001_bib21) 2011; 7
Gersing (10.1016/j.jot.2020.05.001_bib97) 2019; 27
Wiegant (10.1016/j.jot.2020.05.001_bib123) 2013; 21
Robbins (10.1016/j.jot.2020.05.001_bib64) 2011; 63
Messier (10.1016/j.jot.2020.05.001_bib85) 2005; 52
Bliddal (10.1016/j.jot.2020.05.001_bib88) 2011; 70
Harding (10.1016/j.jot.2020.05.001_bib58) 2016; 31
Kalyani (10.1016/j.jot.2020.05.001_bib77) 2014; 2
Pearson (10.1016/j.jot.2020.05.001_bib43) 2017; 7
Dennis (10.1016/j.jot.2020.05.001_bib116) 2006; 21
Beckwee (10.1016/j.jot.2020.05.001_bib37) 2015; 43
Widhalm (10.1016/j.jot.2020.05.001_bib13) 2016; 24
Wu (10.1016/j.jot.2020.05.001_bib54) 2014; 66
Felson (10.1016/j.jot.2020.05.001_bib71) 2004; 50
Odum (10.1016/j.jot.2020.05.001_bib3) 2013; 28
Practitioners RACoG (10.1016/j.jot.2020.05.001_bib11) 2018
Callaghan (10.1016/j.jot.2020.05.001_bib109) 2015; 74
Englund (10.1016/j.jot.2020.05.001_bib19) 2011; 70
Hunter (10.1016/j.jot.2020.05.001_bib93) 2015; 23
Kaspiris (10.1016/j.jot.2020.05.001_bib26) 2015; 22
Wortsman (10.1016/j.jot.2020.05.001_bib34) 2000; 72
Muraki (10.1016/j.jot.2020.05.001_bib75) 2015; 16
Runhaar (10.1016/j.jot.2020.05.001_bib70) 2014; 53
Hart (10.1016/j.jot.2020.05.001_bib17) 1999; 42
Batsis (10.1016/j.jot.2020.05.001_bib81) 2018; 14
Hui (10.1016/j.jot.2020.05.001_bib126) 2010; 39
Spahn (10.1016/j.jot.2020.05.001_bib128) 2006; 14
Kaplan (10.1016/j.jot.2020.05.001_bib50) 2017; 65
Hilton (10.1016/j.jot.2020.05.001_bib80) 2008; 88
Zhang (10.1016/j.jot.2020.05.001_bib45) 2017; 25
Murphy (10.1016/j.jot.2020.05.001_bib2) 2008; 59
Chen (10.1016/j.jot.2020.05.001_bib10) 2020
Messier (10.1016/j.jot.2020.05.001_bib92) 2013; 310
van Outeren (10.1016/j.jot.2020.05.001_bib110) 2017; 25
Bennell (10.1016/j.jot.2020.05.001_bib65) 2011; 70
Frimel (10.1016/j.jot.2020.05.001_bib104) 2008; 40
Sharma (10.1016/j.jot.2020.05.001_bib68) 2007; 66
Guymer (10.1016/j.jot.2020.05.001_bib31) 2007; 15
Jansen (10.1016/j.jot.2020.05.001_bib124) 2020; 15
Campbell (10.1016/j.jot.2020.05.001_bib101) 2012; 8
van Caam (10.1016/j.jot.2020.05.001_bib12) 2014; 54
Wilson (10.1016/j.jot.2020.05.001_bib55) 2006; 24
Draganich (10.1016/j.jot.2020.05.001_bib112) 2006; 88
Felson (10.1016/j.jot.2020.05.001_bib9) 2013; 21
Anandacoomarasamy (10.1016/j.jot.2020.05.001_bib23) 2009; 48
Segal (10.1016/j.jot.2020.05.001_bib60) 2009; 88
Roos (10.1016/j.jot.2020.05.001_bib105) 2016; 12
Runhaar (10.1016/j.jot.2020.05.001_bib87) 2016; 68
McAlindon (10.1016/j.jot.2020.05.001_bib5) 2017; 317
Topp (10.1016/j.jot.2020.05.001_bib106) 2002; 83
Heijink (10.1016/j.jot.2020.05.001_bib66) 2012; 20
Parratte (10.1016/j.jot.2020.05.001_bib133) 2017; 475
de Lange-Brokaar (10.1016/j.jot.2020.05.001_bib41) 2015; 67
Wang (10.1016/j.jot.2020.05.001_bib39) 2018; 26
Radin (10.1016/j.jot.2020.05.001_bib57) 1984; 2
Bennell (10.1016/j.jot.2020.05.001_bib62) 2010; 69
Misra (10.1016/j.jot.2020.05.001_bib83) 2019; 71
van der Voet (10.1016/j.jot.2020.05.001_bib46) 2017; 25
Pozzobon (10.1016/j.jot.2020.05.001_bib130) 2018; 8
Jafarzadeh (10.1016/j.jot.2020.05.001_bib91) 2018; 26
Christensen (10.1016/j.jot.2020.05.001_bib98) 2007; 66
Jordan (10.1016/j.jot.2020.05.001_bib84) 2003; 62
Cushnaghan (10.1016/j.jot.2020.05.001_bib129) 2009; 68
Brandt (10.1016/j.jot.2020.05.001_bib72) 2006; 65
Lafeber (10.1016/j.jot.2020.05.001_bib122) 2006; 18
Landsmeer (10.1016/j.jot.2020.05.001_bib42) 2018; 26
Burr (10.1016/j.jot.2020.05.001_bib33) 2003; 29
Ko (10.1016/j.jot.2020.05.001_bib52) 2016; 34
Englund (10.1016/j.jot.2020.05.001_bib44) 2012; 8
Ebert (10.1016/j.jot.2020.05.001_bib115) 2014; 472
Di Luca (10.1016/j.jot.2020.05.001_bib27) 2015; 105
Felson (10.1016/j.jot.2020.05.001_bib36) 2001; 134
Kanamiya (10.1016/j.jot.2020.05.001_bib127) 2002; 18
Santos (10.1016/j.jot.2020.05.001_bib53) 2019; 27
Erhart (10.1016/j.jot.2020.05.001_bib117) 2010; 28
Brouwer (10.1016/j.jot.2020.05.001_bib118) 2006; 14
Visser (10.1016/j.jot.2020.05.001_bib7) 2015; 74
Nakagawa (10.1016/j.jot.2020.05.001_bib74) 2017; 29
Goldring (10.1016/j.jot.2020.05.001_bib20) 2016; 12
Roemhildt (10.1016/j.jot.2020.05.001_bib48) 2013; 21
Zarka (10.1016/j.jot.2020.05.001_bib32) 2019; 123
Segal (10.1016/j.jot.2020.05.001_bib73) 2011; 39
Zizak (10.1016/j.jot.2020.05.001_bib30) 2003; 141
Miyazaki (10.1016/j.jot.2020.05.001_bib61) 2002; 61
Jenkinson (10.1016/j.jot.2020.05.001_bib94) 2009; 339
Matheny (10.1016/j.jot.2020.05.001_bib38) 2017; 64
Henriksen (10.1016/j.jot.2020.05.001_bib90) 2014; 22
Widmyer (10.1016/j.jot.2020.05.001_bib25) 2013; 65
McAlindon (10.1016/j.jot.2020.05.001_bib102) 2014; 22
Li (10.1016/j.jot.2020.05.001_bib1) 2013; 15
Richette (10.1016/j.jot.2020.05.001_bib86) 2011; 70
Muratovic (10.1016/j.jot.2020.05.001_bib16) 2018; 108
Gersing (10.1016/j.jot.2020.05.001_bib96) 2017; 284
Ramsey (10.1016/j.jot.2020.05.001_bib113) 2007; 89
Pollo (10.1016/j.jot.2020.05.001_bib114) 2002; 30
Schultz (10.1016/j.jot.2020.05.001_bib132) 2019; 327
Anandacoomarasamy (10.1016/j.jot.2020.05.001_bib14) 2012; 71
Radin (10.1016/j.jot.2020.05.001_bib69) 1972; 1
Ko (10.1016/j.jot.2020.05.001_bib51) 2013; 65
Ding (10.1016/j.jot.2020.05.001_bib24) 2005; 13
Scanzello (10.1016/j.jot.2020.05.001_bib40) 2012; 51
Messier (10.1016/j.jot.2020.05.001_bib59) 2014; 22
Tuhanioğlu (10.1016/j.jot.2020.05.001_bib111) 2019; 10
Muratovic (10.1016/j.jot.2020.05.001_bib35) 2015; 18
Mikesky (10.1016/j.jot.2020.05.001_bib76) 2000; 18
Mikesky (10.1016/j.jot.2020.05.001_bib107) 2006; 55
Mauricio (10.1016/j.jot.2020.05.001_bib120) 2018; 25
Slemenda (10.1016/j.jot.2020.05.001_bib79) 1998; 41
Coleman (10.1016/j.jot.2020.05.001_bib49) 2016; 68
Arno (10.1016/j.jot.2020.05.001_bib56) 2015; 33
Dorleijn (10.1016/j.jot.2020.05.001_bib4) 2018; 77
Culliford (10.1016/j.jot.2020.05.001_bib131) 2013; 3
Vanwanseele (10.1016/j.jot.2020.05.001_bib63) 2010; 18
Stenholm (10.1016/j.jot.2020.05.001_bib78) 2009; 33
Rodrigues (10.1016/j.jot.2020.05.001_bib121) 2008; 59
Henriksen (10.1016/j.jot.2020.05.001_bib6) 2015; 175
Messier (10.1016/j.jot.2020.05.001_bib100) 2013; 310
Sharma (10.1016/j.jot.2020.05.001_bib108) 2003; 138
Reijman (10.1016/j.jot.2020.05.001_bib67) 2007; 66
Reina (10.1016/j.jot.2020.05.001_bib15) 2017; 35
Harasymowicz (10.1016/j.jot.2020.05.001_bib18) 2017; 69
Christensen (10.1016/j.jot.2020.05.001_bib89) 2015; 67
References_xml – volume: 61
  start-page: 617
  year: 2002
  end-page: 622
  ident: bib61
  article-title: Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Shimada
– volume: 8
  start-page: 412
  year: 2012
  end-page: 419
  ident: bib44
  article-title: Meniscus pathology, osteoarthritis and the treatment controversy
  publication-title: Nat Rev Rheumatol
  contributor:
    fullname: Guermazi
– volume: 68
  start-page: 1428
  year: 2016
  end-page: 1433
  ident: bib87
  article-title: Prevention of incident knee osteoarthritis by moderate weight loss in overweight and obese females
  publication-title: Arthritis Care Res
  contributor:
    fullname: Bierma-Zeinstra
– volume: 88
  start-page: 180
  year: 2009
  end-page: 188
  ident: bib60
  article-title: Weight, rather than obesity distribution, explains peak external knee adduction moment during level gait
  publication-title: Am J Phys Med Rehabil
  contributor:
    fullname: Khole
– volume: 59
  start-page: 1207
  year: 2008
  end-page: 1213
  ident: bib2
  article-title: Lifetime risk of symptomatic knee osteoarthritis
  publication-title: Arthritis Rheum
  contributor:
    fullname: Koch
– volume: 317
  start-page: 1967
  year: 2017
  end-page: 1975
  ident: bib5
  article-title: Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial
  publication-title: JAMA
  contributor:
    fullname: Zhang
– volume: 28
  start-page: 148
  year: 2013
  end-page: 151
  ident: bib3
  article-title: National obesity trends in total knee arthroplasty
  publication-title: J Arthroplasty
  contributor:
    fullname: Fehring
– volume: 65
  start-page: 1261
  year: 2006
  end-page: 1264
  ident: bib72
  article-title: Yet more evidence that osteoarthritis is not a cartilage disease
  publication-title: Ann Rheum Dis
  contributor:
    fullname: van de Putte
– volume: 475
  start-page: 137
  year: 2017
  end-page: 145
  ident: bib133
  article-title: Do stemmed tibial components in total knee arthroplasty improve outcomes in patients with obesity?
  publication-title: Clin Orthop Relat Res
  contributor:
    fullname: Argenson
– volume: 21
  start-page: 2
  year: 2006
  end-page: 8
  ident: bib116
  article-title: Evaluation of off-loading braces for treatment of unicompartmental knee arthrosis
  publication-title: J Arthroplasty
  contributor:
    fullname: Mahfouz
– volume: 54
  start-page: 588
  year: 2014
  end-page: 600
  ident: bib12
  article-title: Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis
  publication-title: Rheumatology
  contributor:
    fullname: van der Kraan
– volume: 69
  start-page: 1151
  year: 2010
  end-page: 1154
  ident: bib62
  article-title: Bone marrow lesions are related to dynamic knee loading in medial knee osteoarthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Cicuttini
– volume: 64
  start-page: 258
  year: 2017
  end-page: 261
  ident: bib38
  article-title: An in vivo model of a mechanically-induced bone marrow lesion
  publication-title: J Biomech
  contributor:
    fullname: Yang
– volume: 21
  start-page: 346
  year: 2013
  end-page: 357
  ident: bib48
  article-title: Chronic in vivo load alteration induces degenerative changes in the rat tibiofemoral joint
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Badger
– volume: 70
  start-page: 1798
  year: 2011
  end-page: 1803
  ident: bib88
  article-title: Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Christensen
– volume: 14
  start-page: 190
  year: 2006
  end-page: 195
  ident: bib128
  article-title: Factors that influence high tibial osteotomy results in patients with medial gonarthritis: a score to predict the results
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Kahl
– volume: 70
  start-page: 1733
  year: 2011
  end-page: 1739
  ident: bib19
  article-title: Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Crema
– volume: 23
  start-page: 1090
  year: 2015
  end-page: 1098
  ident: bib93
  article-title: The intensive diet and exercise for arthritis (IDEA) trial: 18-month radiographic and MRI outcomes
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Nicklas
– volume: 34
  start-page: 1941
  year: 2016
  end-page: 1949
  ident: bib52
  article-title: Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading
  publication-title: J Orthop Res Off Publ Orthop Res Soc
  contributor:
    fullname: Goldring
– volume: 67
  start-page: 640
  year: 2015
  end-page: 650
  ident: bib89
  article-title: Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: a twelve-month randomized controlled trial
  publication-title: Arthritis Care Res
  contributor:
    fullname: Sorensen
– volume: 22
  start-page: 912
  year: 2014
  end-page: 917
  ident: bib59
  article-title: Influences of alignment and obesity on knee joint loading in osteoarthritic gait
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Hunter
– volume: 65
  start-page: 734
  year: 2017
  end-page: 742
  ident: bib50
  article-title: Cyclic loading of human articular cartilage: the transition from compaction to fatigue
  publication-title: J Mech Behav Biomed Mater
  contributor:
    fullname: Pierce
– volume: 71
  start-page: 232
  year: 2019
  end-page: 237
  ident: bib83
  article-title: Risk of knee osteoarthritis with obesity, sarcopenic obesity, and sarcopenia
  publication-title: Arthrit Rheumatol
  contributor:
    fullname: Nevitt
– volume: 67
  start-page: 733
  year: 2015
  end-page: 740
  ident: bib41
  article-title: Association of pain in knee osteoarthritis with distinct patterns of synovitis
  publication-title: Arthrit Rheumatol (Hoboken, NJ)
  contributor:
    fullname: van Osch
– volume: 8
  start-page: 4389
  year: 2012
  end-page: 4396
  ident: bib101
  article-title: Nanomechanical mapping of the osteochondral interface with contact resonance force microscopy and nanoindentation
  publication-title: Acta Biomater
  contributor:
    fullname: Hurley
– volume: 21
  start-page: 1660
  year: 2013
  end-page: 1667
  ident: bib123
  article-title: Sustained clinical and structural benefit after joint distraction in the treatment of severe knee osteoarthritis
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Mastbergen
– volume: 41
  start-page: 1951
  year: 1998
  end-page: 1959
  ident: bib79
  article-title: Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women?
  publication-title: Arthritis Rheum
  contributor:
    fullname: Braunstein
– volume: 26
  start-page: 1666
  year: 2018
  end-page: 1674
  ident: bib42
  article-title: Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Bindels
– volume: 74
  start-page: 1164
  year: 2015
  end-page: 1170
  ident: bib109
  article-title: A randomised trial of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesions
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Marjanovic
– volume: 30
  start-page: 414
  year: 2002
  end-page: 421
  ident: bib114
  article-title: Reduction of medial compartment loads with valgus bracing of the osteoarthritic knee
  publication-title: Am J Sports Med
  contributor:
    fullname: Wickiewicz
– volume: 175
  start-page: 923
  year: 2015
  end-page: 930
  ident: bib6
  article-title: Evaluation of the benefit of corticosteroid injection before exercise therapy in patients with osteoarthritis of the knee: a randomized clinical trial
  publication-title: JAMA Intern Med
  contributor:
    fullname: Ellegaard
– volume: 71
  start-page: 26
  year: 2012
  end-page: 32
  ident: bib14
  article-title: Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Fransen
– volume: 35
  start-page: 1653
  year: 2017
  end-page: 1660
  ident: bib15
  article-title: BMI-related microstructural changes in the tibial subchondral trabecular bone of patients with knee osteoarthritis
  publication-title: J Orthop Res : Offic Publ Orthop Res Soc
  contributor:
    fullname: Swider
– volume: 134
  start-page: 541
  year: 2001
  end-page: 549
  ident: bib36
  article-title: The association of bone marrow lesions with pain in knee osteoarthritis
  publication-title: Ann Intern Med
  contributor:
    fullname: Skinner
– volume: 25
  start-page: 825
  year: 2018
  end-page: 833
  ident: bib120
  article-title: Acute effects of different orthotic interventions on knee loading parameters in knee osteoarthritis patients with varus malalignment
  publication-title: Knee
  contributor:
    fullname: Rosenbaum
– volume: 62
  start-page: 1145
  year: 2003
  end-page: 1155
  ident: bib84
  article-title: EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT)
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Dieppe
– volume: 53
  start-page: 1618
  year: 2014
  end-page: 1624
  ident: bib70
  article-title: Malalignment: a possible target for prevention of incident knee osteoarthritis in overweight and obese women
  publication-title: Rheumatology
  contributor:
    fullname: Bierma-Zeinstra
– volume: 51
  start-page: 249
  year: 2012
  end-page: 257
  ident: bib40
  article-title: The role of synovitis in osteoarthritis pathogenesis
  publication-title: Bone
  contributor:
    fullname: Goldring
– volume: 15
  start-page: e0227975
  year: 2020
  ident: bib124
  article-title: Knee joint distraction in regular care for treatment of knee osteoarthritis: a comparison with clinical trial data
  publication-title: PloS One
  contributor:
    fullname: Kester
– volume: 40
  start-page: 1213
  year: 2008
  end-page: 1219
  ident: bib104
  article-title: Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults
  publication-title: Med Sci Sports Exerc
  contributor:
    fullname: Villareal
– volume: 26
  start-page: 165
  year: 2018
  end-page: 174
  ident: bib39
  article-title: The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Ding
– volume: 339
  start-page: b3170
  year: 2009
  ident: bib94
  article-title: Effects of dietary intervention and quadriceps strengthening exercises on pain and function in overweight people with knee pain: randomised controlled trial
  publication-title: BMJ (Clin Res Ed)
  contributor:
    fullname: Sach
– volume: 82
  start-page: 872
  year: 2005
  end-page: 878
  ident: bib103
  article-title: Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study
  publication-title: Am J Clin Nutr
  contributor:
    fullname: Tylavsky
– volume: 3
  start-page: e003614
  year: 2013
  ident: bib131
  article-title: A population-based survival analysis describing the association of body mass index on time to revision for total hip and knee replacements: results from the UK general practice research database
  publication-title: BMJ open
  contributor:
    fullname: Arden
– volume: 33
  start-page: 635
  year: 2009
  end-page: 644
  ident: bib78
  article-title: The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study
  publication-title: Int J Obes (Lond)
  contributor:
    fullname: Rantanen
– volume: 141
  start-page: 208
  year: 2003
  end-page: 217
  ident: bib30
  article-title: Characteristics of mineral particles in the human bone/cartilage interface
  publication-title: J Struct Biol
  contributor:
    fullname: Bernstorff
– volume: 83
  start-page: 1187
  year: 2002
  end-page: 1195
  ident: bib106
  article-title: The effect of dynamic versus isometric resistance training on pain and functioning among adults with osteoarthritis of the knee
  publication-title: Arch Phys Med Rehabil
  contributor:
    fullname: Kahaleh
– volume: 15
  start-page: 223
  year: 2013
  ident: bib1
  article-title: Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Zhang
– volume: 29
  start-page: 461
  year: 2017
  end-page: 464
  ident: bib74
  article-title: Associations of knee muscle force, bone malalignment, and knee-joint laxity with osteoarthritis in elderly people
  publication-title: J Phys Ther Sci
  contributor:
    fullname: Maeda
– volume: 2
  start-page: 819
  year: 2014
  end-page: 829
  ident: bib77
  article-title: Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases
  publication-title: Lancet Diabetes Endocrinol
  contributor:
    fullname: Ferrucci
– volume: 24
  start-page: 1126
  year: 2016
  end-page: 1134
  ident: bib95
  article-title: Progression of cartilage degeneration and clinical symptoms in obese and overweight individuals is dependent on the amount of weight loss: 48-month data from the Osteoarthritis Initiative
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Feuerriegel
– volume: 472
  start-page: 915
  year: 2014
  end-page: 922
  ident: bib115
  article-title: Does an unloader brace reduce knee loading in normally aligned knees?
  publication-title: Clin Orthop Relat Res
  contributor:
    fullname: Donnelly
– volume: 14
  start-page: 513
  year: 2018
  end-page: 537
  ident: bib81
  article-title: Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
  publication-title: Nat Rev Endocrinol
  contributor:
    fullname: Villareal
– volume: 64
  start-page: 3947
  year: 2012
  end-page: 3954
  ident: bib82
  article-title: Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study
  publication-title: Arthritis Rheum
  contributor:
    fullname: Kim
– volume: 52
  start-page: 2026
  year: 2005
  end-page: 2032
  ident: bib85
  article-title: Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis
  publication-title: Arthritis Rheum
  contributor:
    fullname: DeVita
– volume: 24
  start-page: 644
  year: 2016
  end-page: 652
  ident: bib13
  article-title: Osteoarthritis in morbidly obese children and adolescents, an age-matched controlled study
  publication-title: Knee Surg Sports Traumatol Arthrosc
  contributor:
    fullname: Friedrich
– volume: 33
  start-page: 584
  year: 2015
  end-page: 590
  ident: bib56
  article-title: Tibiofemoral contact mechanics following a horizontal cleavage lesion in the posterior horn of the medial meniscus
  publication-title: J Orthop Res
  contributor:
    fullname: Walker
– volume: 1
  start-page: 519
  year: 1972
  end-page: 522
  ident: bib69
  article-title: Role of mechanical factors in pathogenesis of primary osteoarthritis
  publication-title: Lancet
  contributor:
    fullname: Rose
– volume: 22
  start-page: 639
  year: 2014
  end-page: 646
  ident: bib90
  article-title: Structural changes in the knee during weight loss maintenance after a significant weight loss in obese patients with osteoarthritis: a report of secondary outcome analyses from a randomized controlled trial
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Lohmander
– volume: 72
  start-page: 1125
  year: 2013
  end-page: 1135
  ident: bib99
  article-title: EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Conaghan
– volume: 69
  start-page: 1396
  year: 2017
  end-page: 1406
  ident: bib18
  article-title: Regional differences between perisynovial and infrapatellar adipose tissue depots and their response to class II and class III obesity in patients with osteoarthritis
  publication-title: Arthrit Rheumatol (Hoboken, NJ)
  contributor:
    fullname: Simpson
– volume: 28
  start-page: 873
  year: 2010
  end-page: 879
  ident: bib117
  article-title: Changes in knee adduction moment, pain, and functionality with a variable-stiffness walking shoe after 6 months
  publication-title: J Orthop Res
  contributor:
    fullname: Andriacchi
– volume: 2
  start-page: 221
  year: 1984
  end-page: 234
  ident: bib57
  article-title: Effects of mechanical loading on the tissues of the rabbit knee
  publication-title: J Orthop Res Offic Publ Orthop Res Soc
  contributor:
    fullname: Goodwin
– volume: 27
  start-page: 863
  year: 2019
  end-page: 870
  ident: bib97
  article-title: Weight loss regimen in obese and overweight individuals is associated with reduced cartilage degeneration: 96-month data from the Osteoarthritis Initiative
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Feuerriegel
– volume: 27
  start-page: 1392
  year: 2019
  end-page: 1402
  ident: bib53
  article-title: Propagation of microcracks in collagen networks of cartilage under mechanical loads
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Pierce
– volume: 22
  start-page: 363
  year: 2014
  end-page: 388
  ident: bib102
  article-title: OARSI guidelines for the non-surgical management of knee osteoarthritis
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Bierma-Zeinstra
– volume: 55
  start-page: 690
  year: 2006
  end-page: 699
  ident: bib107
  article-title: Effects of strength training on the incidence and progression of knee osteoarthritis
  publication-title: Arthritis Rheum
  contributor:
    fullname: Lane
– volume: 74
  start-page: 1842
  year: 2015
  end-page: 1847
  ident: bib7
  article-title: The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Kloppenburg
– volume: 10
  start-page: 180
  year: 1999
  end-page: 192
  ident: bib29
  article-title: Importance of subchondral bone to articular cartilage in health and disease
  publication-title: Top Magn Reson Imag TMRI
  contributor:
    fullname: Trattnig
– volume: 14
  start-page: 13
  year: 2006
  end-page: 29
  ident: bib22
  article-title: Osteoarthritis cartilage histopathology: grading and staging
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Revell
– volume: 25
  start-page: 694
  year: 2017
  end-page: 699
  ident: bib45
  article-title: Factors associated with meniscal body extrusion on knee MRI in overweight and obese women
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Runhaar
– volume: 310
  start-page: 1263
  year: 2013
  end-page: 1273
  ident: bib100
  article-title: Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the idea randomized clinical trial
  publication-title: JAMA
  contributor:
    fullname: DeVita
– volume: 10
  start-page: 168
  year: 2019
  end-page: 173
  ident: bib111
  article-title: High tibial osteotomy in obese patients: is successful surgery enough for a good outcome?
  publication-title: J Clin Orthop Trauma
  contributor:
    fullname: Gültekin
– volume: 68
  start-page: 662
  year: 2016
  end-page: 671
  ident: bib49
  article-title: Injurious loading of articular cartilage compromises chondrocyte respiratory function
  publication-title: Arthrit Rheumatol (Hoboken, NJ)
  contributor:
    fullname: Martin
– volume: 20
  start-page: 423
  year: 2012
  end-page: 435
  ident: bib66
  article-title: Biomechanical considerations in the pathogenesis of osteoarthritis of the knee
  publication-title: Knee Surg Sports Traumatol Arthrosc Offic J ESSKA
  contributor:
    fullname: Espregueira-Mendes
– volume: 66
  start-page: 433
  year: 2007
  end-page: 439
  ident: bib98
  article-title: Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Bliddal
– volume: 25
  start-page: 1988
  year: 2017
  end-page: 1993
  ident: bib110
  article-title: Is a high tibial osteotomy (HTO) superior to non-surgical treatment in patients with varus malaligned medial knee osteoarthritis (OA)? A propensity matched study using 2 randomized controlled trial (RCT) datasets
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Bierma-Zeinstra
– volume: 90
  start-page: 247
  year: 2011
  end-page: 262
  ident: bib119
  article-title: Efficacy of knee braces and foot orthoses in conservative management of knee osteoarthritis: a systematic review
  publication-title: Am J Phys Med Rehabil
  contributor:
    fullname: Dewan
– volume: 12
  start-page: 632
  year: 2016
  end-page: 644
  ident: bib20
  article-title: Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk
  publication-title: Nat Rev Rheumatol
  contributor:
    fullname: Goldring
– volume: 88
  start-page: 1336
  year: 2008
  end-page: 1344
  ident: bib80
  article-title: Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function
  publication-title: Phys Ther
  contributor:
    fullname: Sinacore
– volume: 59
  start-page: 603
  year: 2008
  end-page: 608
  ident: bib121
  article-title: Effectiveness of medial-wedge insole treatment for valgus knee osteoarthritis
  publication-title: Arthritis Rheum
  contributor:
    fullname: Fuller
– volume: 21
  start-page: 10
  year: 2013
  end-page: 15
  ident: bib9
  article-title: Osteoarthritis as a disease of mechanics
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Felson
– volume: 123
  start-page: 1
  year: 2019
  end-page: 7
  ident: bib32
  article-title: Microcracks in subchondral bone plate is linked to less cartilage damage
  publication-title: Bone
  contributor:
    fullname: Oudet
– volume: 89
  start-page: 2398
  year: 2007
  end-page: 2407
  ident: bib113
  article-title: A mechanical theory for the effectiveness of bracing for medial compartment osteoarthritis of the knee
  publication-title: J Bone Joint Surg Am
  contributor:
    fullname: Snyder-Mackler
– volume: 18
  start-page: 54
  year: 2015
  ident: bib35
  article-title: Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Otto
– volume: 26
  start-page: 775
  year: 2018
  end-page: 782
  ident: bib91
  article-title: Changes in the structural features of osteoarthritis in a year of weight loss
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Eckstein
– volume: 138
  start-page: 613
  year: 2003
  end-page: 619
  ident: bib108
  article-title: Quadriceps strength and osteoarthritis progression in malaligned and lax knees
  publication-title: Ann Intern Med
  contributor:
    fullname: Hayes
– volume: 7
  start-page: 3451
  year: 2017
  ident: bib43
  article-title: IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity
  publication-title: Sci Rep
  contributor:
    fullname: Smith
– year: 2018
  ident: bib11
  article-title: Guideline for the management of knee and hip osteoarthritis
  contributor:
    fullname: Practitioners RACoG
– year: 2020
  ident: bib10
  article-title: Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Bulsara
– volume: 70
  start-page: 1770
  year: 2011
  end-page: 1774
  ident: bib65
  article-title: Higher dynamic medial knee load predicts greater cartilage loss over 12 months in medial knee osteoarthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Hinman
– volume: 24
  start-page: 220
  year: 2006
  end-page: 228
  ident: bib55
  article-title: Causes of mechanically induced collagen damage in articular cartilage
  publication-title: J Orthop Res Offic Publ Orthop Res Soc
  contributor:
    fullname: Huiskes
– volume: 284
  start-page: 508
  year: 2017
  end-page: 520
  ident: bib96
  article-title: Is weight loss associated with less progression of changes in knee articular cartilage among obese and overweight patients as assessed with MR imaging over 48 Months? Data from the osteoarthritis initiative
  publication-title: Radiology
  contributor:
    fullname: Guimaraes
– volume: 7
  start-page: 50
  year: 2011
  end-page: 56
  ident: bib21
  article-title: The role of the cartilage matrix in osteoarthritis
  publication-title: Nat Rev Rheumatol
  contributor:
    fullname: Saxne
– volume: 29
  start-page: 675
  year: 2003
  end-page: 685
  ident: bib33
  article-title: Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?
  publication-title: Rheum Dis Clin N Am
  contributor:
    fullname: Radin
– volume: 25
  start-page: 703
  year: 2017
  end-page: 714
  ident: bib8
  article-title: Efficacy and treatment response of intra-articular corticosteroid injections in patients with symptomatic knee osteoarthritis
  publication-title: J Am Acad Orthop Surg
  contributor:
    fullname: Smith
– volume: 88
  start-page: 2645
  year: 2006
  end-page: 2652
  ident: bib112
  article-title: The effectiveness of self-adjustable custom and off-the-shelf bracing in the treatment of varus gonarthrosis
  publication-title: J Bone Joint Surg Am
  contributor:
    fullname: Nasson
– volume: 37
  start-page: 1238
  year: 2013
  end-page: 1246
  ident: bib47
  article-title: Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus
  publication-title: Int J Obes (Lond)
  contributor:
    fullname: Brophy
– volume: 42
  start-page: 17
  year: 1999
  end-page: 24
  ident: bib17
  article-title: Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study
  publication-title: Arthritis Rheum
  contributor:
    fullname: Spector
– volume: 72
  start-page: 690
  year: 2000
  end-page: 693
  ident: bib34
  article-title: Decreased bioavailability of vitamin D in obesity
  publication-title: Am J Clin Nutr
  contributor:
    fullname: Holick
– volume: 25
  start-page: 1299
  year: 2017
  end-page: 1303
  ident: bib46
  article-title: Baseline meniscal extrusion associated with incident knee osteoarthritis after 30 months in overweight and obese women
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Bierma-Zeinstra
– volume: 70
  start-page: 139
  year: 2011
  ident: bib86
  article-title: Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Lacorte
– volume: 8
  start-page: e017689
  year: 2018
  ident: bib130
  article-title: Can obesity and physical activity predict outcomes of elective knee or hip surgery due to osteoarthritis? A meta-analysis of cohort studies
  publication-title: BMJ open
  contributor:
    fullname: Ferreira
– volume: 13
  start-page: 350
  year: 2005
  end-page: 361
  ident: bib24
  article-title: Knee structural alteration and BMI: a cross-sectional study
  publication-title: Obes Res
  contributor:
    fullname: Jones
– volume: 31
  start-page: 79
  year: 2016
  end-page: 86
  ident: bib58
  article-title: Obesity is associated with higher absolute tibiofemoral contact and muscle forces during gait with and without knee osteoarthritis
  publication-title: Clin Biomech (Bristol, Avon)
  contributor:
    fullname: Astephen Wilson
– volume: 12
  start-page: 92
  year: 2016
  end-page: 101
  ident: bib105
  article-title: Strategies for the prevention of knee osteoarthritis
  publication-title: Nat Rev Rheumatol
  contributor:
    fullname: Arden
– volume: 15
  start-page: 1437
  year: 2007
  end-page: 1442
  ident: bib31
  article-title: A study of the prevalence and associations of subchondral bone marrow lesions in the knees of healthy, middle-aged women
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Davis
– volume: 18
  start-page: 725
  year: 2002
  end-page: 729
  ident: bib127
  article-title: The influences of biomechanical factors on cartilage regeneration after high tibial osteotomy for knees with medial compartment osteoarthritis: clinical and arthroscopic observations
  publication-title: Arthrosc J Arthrosc Relat Surg
  contributor:
    fullname: Yoshimura
– volume: 43
  start-page: 3093
  year: 2015
  end-page: 3107
  ident: bib37
  article-title: The influence of joint loading on bone marrow lesions in the knee: a systematic review with meta-analysis
  publication-title: Am J Sports Med
  contributor:
    fullname: Bautmans
– volume: 14
  start-page: 777
  year: 2006
  end-page: 783
  ident: bib118
  article-title: Brace treatment for osteoarthritis of the knee: a prospective randomized multi-centre trial
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Bierma-Zeinstra
– volume: 108
  start-page: 193
  year: 2018
  end-page: 201
  ident: bib16
  article-title: Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis
  publication-title: Bone
  contributor:
    fullname: Kuliwaba
– volume: 65
  start-page: 2615
  year: 2013
  end-page: 2622
  ident: bib25
  article-title: High body mass index is associated with increased diurnal strains in the articular cartilage of the knee
  publication-title: Arthritis Rheum
  contributor:
    fullname: Moorman
– volume: 310
  start-page: 1263
  year: 2013
  end-page: 1273
  ident: bib92
  article-title: Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
  publication-title: JAMA
  contributor:
    fullname: DeVita
– volume: 50
  start-page: 3904
  year: 2004
  end-page: 3909
  ident: bib71
  article-title: The effect of body weight on progression of knee osteoarthritis is dependent on alignment
  publication-title: Arthritis Rheum
  contributor:
    fullname: Hunter
– volume: 66
  start-page: 158
  year: 2007
  end-page: 162
  ident: bib67
  article-title: Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Lievense
– volume: 70
  start-page: 1441
  year: 2011
  end-page: 1446
  ident: bib125
  article-title: Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Castelein
– volume: 66
  start-page: 1256
  year: 2014
  end-page: 1265
  ident: bib54
  article-title: Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets
  publication-title: Arthritis Rheumatol (Hoboken, NJ)
  contributor:
    fullname: Sandell
– volume: 18
  start-page: 171
  year: 2000
  end-page: 175
  ident: bib76
  article-title: Relationship between quadriceps strength and rate of loading during gait in women
  publication-title: J Orthop Res : Offic Publ Orthop Res Soc
  contributor:
    fullname: Thompson
– volume: 18
  start-page: 519
  year: 2006
  end-page: 525
  ident: bib122
  article-title: Unloading joints to treat osteoarthritis, including joint distraction
  publication-title: Curr Opin Rheumatol
  contributor:
    fullname: Marijnissen
– volume: 63
  start-page: 991
  year: 2011
  end-page: 997
  ident: bib64
  article-title: Association of pain with frequency and magnitude of knee loading in knee osteoarthritis
  publication-title: Arthritis Care Res
  contributor:
    fullname: Maly
– volume: 16
  start-page: 305
  year: 2015
  ident: bib75
  article-title: Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: the ROAD study
  publication-title: BMC Muscoskel Disord
  contributor:
    fullname: Yoshida
– volume: 66
  start-page: 141
  year: 2007
  end-page: 142
  ident: bib68
  article-title: Overweight: advancing our understanding of its impact on the knee and the hip
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Chang
– volume: 18
  start-page: 894
  year: 2010
  end-page: 901
  ident: bib63
  article-title: The relationship between knee adduction moment and cartilage and meniscus morphology in women with osteoarthritis
  publication-title: Osteoarthritis Cartilage
  contributor:
    fullname: Baker
– volume: 39
  start-page: 64
  year: 2010
  end-page: 70
  ident: bib126
  article-title: Long-term survival of high tibial osteotomy for medial compartment osteoarthritis of the knee
  publication-title: Am J Sports Med
  contributor:
    fullname: van der Tempel
– volume: 68
  start-page: 642
  year: 2009
  ident: bib129
  article-title: Long-term outcome following total knee arthroplasty: a controlled longitudinal study
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Cox
– volume: 77
  start-page: 875
  year: 2018
  end-page: 882
  ident: bib4
  article-title: Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Bindels
– volume: 48
  start-page: 1290
  year: 2009
  end-page: 1293
  ident: bib23
  article-title: Cartilage defects are associated with physical disability in obese adults
  publication-title: Rheumatology
  contributor:
    fullname: Fransen
– volume: 65
  start-page: 1569
  year: 2013
  end-page: 1578
  ident: bib51
  article-title: In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae
  publication-title: Arthritis Rheum
  contributor:
    fullname: Goldring
– volume: 51
  start-page: 204
  year: 2012
  end-page: 211
  ident: bib28
  article-title: Osteochondral alterations in osteoarthritis
  publication-title: Bone
  contributor:
    fullname: Walsh
– volume: 39
  start-page: 44
  year: 2011
  end-page: 50
  ident: bib73
  article-title: Is quadriceps muscle weakness a risk factor for incident or progressive knee osteoarthritis?
  publication-title: Phys Sportsmed
  contributor:
    fullname: Glass
– volume: 105
  start-page: 34
  year: 2015
  end-page: 52
  ident: bib27
  article-title: The osteochondral interface as a gradient tissue: from development to the fabrication of gradient scaffolds for regenerative medicine
  publication-title: Birth Defects Res C Embryo Today
  contributor:
    fullname: Moroni
– volume: 22
  start-page: 143
  year: 2015
  end-page: 151
  ident: bib26
  article-title: Macrophage-specific metalloelastase (MMP-12) immunoexpression in the osteochondral unit in osteoarthritis correlates with BMI and disease severity
  publication-title: Pathophysiology
  contributor:
    fullname: Kouvaras
– volume: 327
  start-page: 607
  year: 2019
  end-page: 610
  ident: bib132
  article-title: The use of stems for morbid obesity in total knee arthroplasty
  publication-title: J Knee Surg
  contributor:
    fullname: Huddleston
– volume: 66
  start-page: 141
  issue: 2
  year: 2007
  ident: 10.1016/j.jot.2020.05.001_bib68
  article-title: Overweight: advancing our understanding of its impact on the knee and the hip
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2006.059931
  contributor:
    fullname: Sharma
– volume: 29
  start-page: 461
  issue: 3
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib74
  article-title: Associations of knee muscle force, bone malalignment, and knee-joint laxity with osteoarthritis in elderly people
  publication-title: J Phys Ther Sci
  doi: 10.1589/jpts.29.461
  contributor:
    fullname: Nakagawa
– volume: 70
  start-page: 1441
  issue: 8
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib125
  article-title: Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2010.142364
  contributor:
    fullname: Intema
– volume: 15
  start-page: e0227975
  issue: 1
  year: 2020
  ident: 10.1016/j.jot.2020.05.001_bib124
  article-title: Knee joint distraction in regular care for treatment of knee osteoarthritis: a comparison with clinical trial data
  publication-title: PloS One
  doi: 10.1371/journal.pone.0227975
  contributor:
    fullname: Jansen
– volume: 88
  start-page: 2645
  issue: 12
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib112
  article-title: The effectiveness of self-adjustable custom and off-the-shelf bracing in the treatment of varus gonarthrosis
  publication-title: J Bone Joint Surg Am
  doi: 10.2106/00004623-200612000-00012
  contributor:
    fullname: Draganich
– volume: 8
  start-page: 412
  issue: 7
  year: 2012
  ident: 10.1016/j.jot.2020.05.001_bib44
  article-title: Meniscus pathology, osteoarthritis and the treatment controversy
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2012.69
  contributor:
    fullname: Englund
– volume: 18
  start-page: 894
  issue: 7
  year: 2010
  ident: 10.1016/j.jot.2020.05.001_bib63
  article-title: The relationship between knee adduction moment and cartilage and meniscus morphology in women with osteoarthritis
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2010.04.006
  contributor:
    fullname: Vanwanseele
– volume: 10
  start-page: 168
  year: 2019
  ident: 10.1016/j.jot.2020.05.001_bib111
  article-title: High tibial osteotomy in obese patients: is successful surgery enough for a good outcome?
  publication-title: J Clin Orthop Trauma
  doi: 10.1016/j.jcot.2018.09.004
  contributor:
    fullname: Tuhanioğlu
– volume: 69
  start-page: 1396
  issue: 7
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib18
  article-title: Regional differences between perisynovial and infrapatellar adipose tissue depots and their response to class II and class III obesity in patients with osteoarthritis
  publication-title: Arthrit Rheumatol (Hoboken, NJ)
  doi: 10.1002/art.40102
  contributor:
    fullname: Harasymowicz
– volume: 31
  start-page: 79
  year: 2016
  ident: 10.1016/j.jot.2020.05.001_bib58
  article-title: Obesity is associated with higher absolute tibiofemoral contact and muscle forces during gait with and without knee osteoarthritis
  publication-title: Clin Biomech (Bristol, Avon)
  doi: 10.1016/j.clinbiomech.2015.09.017
  contributor:
    fullname: Harding
– volume: 53
  start-page: 1618
  issue: 9
  year: 2014
  ident: 10.1016/j.jot.2020.05.001_bib70
  article-title: Malalignment: a possible target for prevention of incident knee osteoarthritis in overweight and obese women
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/keu141
  contributor:
    fullname: Runhaar
– volume: 66
  start-page: 433
  issue: 4
  year: 2007
  ident: 10.1016/j.jot.2020.05.001_bib98
  article-title: Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2006.065904
  contributor:
    fullname: Christensen
– volume: 71
  start-page: 26
  issue: 1
  year: 2012
  ident: 10.1016/j.jot.2020.05.001_bib14
  article-title: Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2010.144725
  contributor:
    fullname: Anandacoomarasamy
– year: 2020
  ident: 10.1016/j.jot.2020.05.001_bib10
  article-title: Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2020-216942
  contributor:
    fullname: Chen
– volume: 2
  start-page: 819
  issue: 10
  year: 2014
  ident: 10.1016/j.jot.2020.05.001_bib77
  article-title: Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases
  publication-title: Lancet Diabetes Endocrinol
  doi: 10.1016/S2213-8587(14)70034-8
  contributor:
    fullname: Kalyani
– volume: 68
  start-page: 642
  issue: 5
  year: 2009
  ident: 10.1016/j.jot.2020.05.001_bib129
  article-title: Long-term outcome following total knee arthroplasty: a controlled longitudinal study
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2008.093229
  contributor:
    fullname: Cushnaghan
– volume: 64
  start-page: 3947
  issue: 12
  year: 2012
  ident: 10.1016/j.jot.2020.05.001_bib82
  article-title: Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: a cross-sectional study
  publication-title: Arthritis Rheum
  doi: 10.1002/art.37696
  contributor:
    fullname: Lee
– volume: 70
  start-page: 139
  issue: 1
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib86
  article-title: Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2010.134015
  contributor:
    fullname: Richette
– volume: 2
  start-page: 221
  issue: 3
  year: 1984
  ident: 10.1016/j.jot.2020.05.001_bib57
  article-title: Effects of mechanical loading on the tissues of the rabbit knee
  publication-title: J Orthop Res Offic Publ Orthop Res Soc
  doi: 10.1002/jor.1100020303
  contributor:
    fullname: Radin
– volume: 42
  start-page: 17
  issue: 1
  year: 1999
  ident: 10.1016/j.jot.2020.05.001_bib17
  article-title: Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study
  publication-title: Arthritis Rheum
  doi: 10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E
  contributor:
    fullname: Hart
– volume: 62
  start-page: 1145
  issue: 12
  year: 2003
  ident: 10.1016/j.jot.2020.05.001_bib84
  article-title: EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT)
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2003.011742
  contributor:
    fullname: Jordan
– volume: 28
  start-page: 148
  issue: 8 Suppl
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib3
  article-title: National obesity trends in total knee arthroplasty
  publication-title: J Arthroplasty
  doi: 10.1016/j.arth.2013.02.036
  contributor:
    fullname: Odum
– volume: 72
  start-page: 690
  issue: 3
  year: 2000
  ident: 10.1016/j.jot.2020.05.001_bib34
  article-title: Decreased bioavailability of vitamin D in obesity
  publication-title: Am J Clin Nutr
  doi: 10.1093/ajcn/72.3.690
  contributor:
    fullname: Wortsman
– volume: 21
  start-page: 346
  issue: 2
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib48
  article-title: Chronic in vivo load alteration induces degenerative changes in the rat tibiofemoral joint
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2012.10.014
  contributor:
    fullname: Roemhildt
– volume: 18
  start-page: 54
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib35
  article-title: Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration
  publication-title: Arthritis Res Ther
  doi: 10.1186/s13075-016-0953-x
  contributor:
    fullname: Muratovic
– volume: 1
  start-page: 519
  issue: 7749
  year: 1972
  ident: 10.1016/j.jot.2020.05.001_bib69
  article-title: Role of mechanical factors in pathogenesis of primary osteoarthritis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(72)90179-1
  contributor:
    fullname: Radin
– volume: 339
  start-page: b3170
  year: 2009
  ident: 10.1016/j.jot.2020.05.001_bib94
  article-title: Effects of dietary intervention and quadriceps strengthening exercises on pain and function in overweight people with knee pain: randomised controlled trial
  publication-title: BMJ (Clin Res Ed)
  doi: 10.1136/bmj.b3170
  contributor:
    fullname: Jenkinson
– volume: 15
  start-page: 223
  issue: 6
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib1
  article-title: Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar4405
  contributor:
    fullname: Li
– volume: 68
  start-page: 662
  issue: 3
  year: 2016
  ident: 10.1016/j.jot.2020.05.001_bib49
  article-title: Injurious loading of articular cartilage compromises chondrocyte respiratory function
  publication-title: Arthrit Rheumatol (Hoboken, NJ)
  doi: 10.1002/art.39460
  contributor:
    fullname: Coleman
– volume: 12
  start-page: 92
  issue: 2
  year: 2016
  ident: 10.1016/j.jot.2020.05.001_bib105
  article-title: Strategies for the prevention of knee osteoarthritis
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2015.135
  contributor:
    fullname: Roos
– volume: 39
  start-page: 44
  issue: 4
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib73
  article-title: Is quadriceps muscle weakness a risk factor for incident or progressive knee osteoarthritis?
  publication-title: Phys Sportsmed
  doi: 10.3810/psm.2011.11.1938
  contributor:
    fullname: Segal
– volume: 67
  start-page: 640
  issue: 5
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib89
  article-title: Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: a twelve-month randomized controlled trial
  publication-title: Arthritis Care Res
  doi: 10.1002/acr.22504
  contributor:
    fullname: Christensen
– volume: 8
  start-page: 4389
  issue: 12
  year: 2012
  ident: 10.1016/j.jot.2020.05.001_bib101
  article-title: Nanomechanical mapping of the osteochondral interface with contact resonance force microscopy and nanoindentation
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2012.07.042
  contributor:
    fullname: Campbell
– volume: 68
  start-page: 1428
  issue: 10
  year: 2016
  ident: 10.1016/j.jot.2020.05.001_bib87
  article-title: Prevention of incident knee osteoarthritis by moderate weight loss in overweight and obese females
  publication-title: Arthritis Care Res
  doi: 10.1002/acr.22854
  contributor:
    fullname: Runhaar
– volume: 82
  start-page: 872
  issue: 4
  year: 2005
  ident: 10.1016/j.jot.2020.05.001_bib103
  article-title: Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study
  publication-title: Am J Clin Nutr
  doi: 10.1093/ajcn/82.4.872
  contributor:
    fullname: Newman
– volume: 33
  start-page: 584
  issue: 4
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib56
  article-title: Tibiofemoral contact mechanics following a horizontal cleavage lesion in the posterior horn of the medial meniscus
  publication-title: J Orthop Res
  doi: 10.1002/jor.22809
  contributor:
    fullname: Arno
– volume: 26
  start-page: 165
  issue: 2
  year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib39
  article-title: The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2017.11.015
  contributor:
    fullname: Wang
– volume: 65
  start-page: 734
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib50
  article-title: Cyclic loading of human articular cartilage: the transition from compaction to fatigue
  publication-title: J Mech Behav Biomed Mater
  doi: 10.1016/j.jmbbm.2016.09.040
  contributor:
    fullname: Kaplan
– volume: 64
  start-page: 258
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib38
  article-title: An in vivo model of a mechanically-induced bone marrow lesion
  publication-title: J Biomech
  doi: 10.1016/j.jbiomech.2017.09.020
  contributor:
    fullname: Matheny
– volume: 74
  start-page: 1842
  issue: 10
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib7
  article-title: The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2013-205012
  contributor:
    fullname: Visser
– volume: 7
  start-page: 50
  issue: 1
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib21
  article-title: The role of the cartilage matrix in osteoarthritis
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2010.198
  contributor:
    fullname: Heinegard
– volume: 30
  start-page: 414
  issue: 3
  year: 2002
  ident: 10.1016/j.jot.2020.05.001_bib114
  article-title: Reduction of medial compartment loads with valgus bracing of the osteoarthritic knee
  publication-title: Am J Sports Med
  doi: 10.1177/03635465020300031801
  contributor:
    fullname: Pollo
– volume: 18
  start-page: 725
  issue: 7
  year: 2002
  ident: 10.1016/j.jot.2020.05.001_bib127
  article-title: The influences of biomechanical factors on cartilage regeneration after high tibial osteotomy for knees with medial compartment osteoarthritis: clinical and arthroscopic observations
  publication-title: Arthrosc J Arthrosc Relat Surg
  doi: 10.1053/jars.2002.35258
  contributor:
    fullname: Kanamiya
– volume: 41
  start-page: 1951
  issue: 11
  year: 1998
  ident: 10.1016/j.jot.2020.05.001_bib79
  article-title: Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women?
  publication-title: Arthritis Rheum
  doi: 10.1002/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9
  contributor:
    fullname: Slemenda
– volume: 472
  start-page: 915
  issue: 3
  year: 2014
  ident: 10.1016/j.jot.2020.05.001_bib115
  article-title: Does an unloader brace reduce knee loading in normally aligned knees?
  publication-title: Clin Orthop Relat Res
  doi: 10.1007/s11999-013-3297-8
  contributor:
    fullname: Ebert
– volume: 10
  start-page: 180
  issue: 3
  year: 1999
  ident: 10.1016/j.jot.2020.05.001_bib29
  article-title: Importance of subchondral bone to articular cartilage in health and disease
  publication-title: Top Magn Reson Imag TMRI
  doi: 10.1097/00002142-199906000-00002
  contributor:
    fullname: Imhof
– volume: 25
  start-page: 1988
  issue: 12
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib110
  article-title: Is a high tibial osteotomy (HTO) superior to non-surgical treatment in patients with varus malaligned medial knee osteoarthritis (OA)? A propensity matched study using 2 randomized controlled trial (RCT) datasets
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2017.09.003
  contributor:
    fullname: van Outeren
– volume: 66
  start-page: 1256
  issue: 5
  year: 2014
  ident: 10.1016/j.jot.2020.05.001_bib54
  article-title: Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets
  publication-title: Arthritis Rheumatol (Hoboken, NJ)
  doi: 10.1002/art.38375
  contributor:
    fullname: Wu
– volume: 72
  start-page: 1125
  issue: 7
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib99
  article-title: EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2012-202745
  contributor:
    fullname: Fernandes
– volume: 27
  start-page: 1392
  issue: 9
  year: 2019
  ident: 10.1016/j.jot.2020.05.001_bib53
  article-title: Propagation of microcracks in collagen networks of cartilage under mechanical loads
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2019.04.017
  contributor:
    fullname: Santos
– volume: 24
  start-page: 220
  issue: 2
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib55
  article-title: Causes of mechanically induced collagen damage in articular cartilage
  publication-title: J Orthop Res Offic Publ Orthop Res Soc
  doi: 10.1002/jor.20027
  contributor:
    fullname: Wilson
– volume: 67
  start-page: 733
  issue: 3
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib41
  article-title: Association of pain in knee osteoarthritis with distinct patterns of synovitis
  publication-title: Arthrit Rheumatol (Hoboken, NJ)
  doi: 10.1002/art.38965
  contributor:
    fullname: de Lange-Brokaar
– volume: 69
  start-page: 1151
  issue: 6
  year: 2010
  ident: 10.1016/j.jot.2020.05.001_bib62
  article-title: Bone marrow lesions are related to dynamic knee loading in medial knee osteoarthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2009.118182
  contributor:
    fullname: Bennell
– volume: 70
  start-page: 1770
  issue: 10
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib65
  article-title: Higher dynamic medial knee load predicts greater cartilage loss over 12 months in medial knee osteoarthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2010.147082
  contributor:
    fullname: Bennell
– volume: 22
  start-page: 363
  issue: 3
  year: 2014
  ident: 10.1016/j.jot.2020.05.001_bib102
  article-title: OARSI guidelines for the non-surgical management of knee osteoarthritis
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2014.01.003
  contributor:
    fullname: McAlindon
– volume: 27
  start-page: 863
  issue: 6
  year: 2019
  ident: 10.1016/j.jot.2020.05.001_bib97
  article-title: Weight loss regimen in obese and overweight individuals is associated with reduced cartilage degeneration: 96-month data from the Osteoarthritis Initiative
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2019.01.018
  contributor:
    fullname: Gersing
– volume: 70
  start-page: 1798
  issue: 10
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib88
  article-title: Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2010.142018
  contributor:
    fullname: Bliddal
– volume: 3
  start-page: e003614
  issue: 11
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib131
  article-title: A population-based survival analysis describing the association of body mass index on time to revision for total hip and knee replacements: results from the UK general practice research database
  publication-title: BMJ open
  doi: 10.1136/bmjopen-2013-003614
  contributor:
    fullname: Culliford
– volume: 16
  start-page: 305
  issue: 1
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib75
  article-title: Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: the ROAD study
  publication-title: BMC Muscoskel Disord
  doi: 10.1186/s12891-015-0737-5
  contributor:
    fullname: Muraki
– volume: 61
  start-page: 617
  issue: 7
  year: 2002
  ident: 10.1016/j.jot.2020.05.001_bib61
  article-title: Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.61.7.617
  contributor:
    fullname: Miyazaki
– volume: 40
  start-page: 1213
  issue: 7
  year: 2008
  ident: 10.1016/j.jot.2020.05.001_bib104
  article-title: Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults
  publication-title: Med Sci Sports Exerc
  doi: 10.1249/MSS.0b013e31816a85ce
  contributor:
    fullname: Frimel
– volume: 65
  start-page: 1261
  issue: 10
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib72
  article-title: Yet more evidence that osteoarthritis is not a cartilage disease
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2006.058347
  contributor:
    fullname: Brandt
– volume: 18
  start-page: 171
  issue: 2
  year: 2000
  ident: 10.1016/j.jot.2020.05.001_bib76
  article-title: Relationship between quadriceps strength and rate of loading during gait in women
  publication-title: J Orthop Res : Offic Publ Orthop Res Soc
  doi: 10.1002/jor.1100180202
  contributor:
    fullname: Mikesky
– volume: 105
  start-page: 34
  issue: 1
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib27
  article-title: The osteochondral interface as a gradient tissue: from development to the fabrication of gradient scaffolds for regenerative medicine
  publication-title: Birth Defects Res C Embryo Today
  doi: 10.1002/bdrc.21092
  contributor:
    fullname: Di Luca
– volume: 25
  start-page: 825
  issue: 5
  year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib120
  article-title: Acute effects of different orthotic interventions on knee loading parameters in knee osteoarthritis patients with varus malalignment
  publication-title: Knee
  doi: 10.1016/j.knee.2018.06.017
  contributor:
    fullname: Mauricio
– volume: 23
  start-page: 1090
  issue: 7
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib93
  article-title: The intensive diet and exercise for arthritis (IDEA) trial: 18-month radiographic and MRI outcomes
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2015.03.034
  contributor:
    fullname: Hunter
– volume: 26
  start-page: 775
  issue: 6
  year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib91
  article-title: Changes in the structural features of osteoarthritis in a year of weight loss
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2018.03.003
  contributor:
    fullname: Jafarzadeh
– volume: 18
  start-page: 519
  issue: 5
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib122
  article-title: Unloading joints to treat osteoarthritis, including joint distraction
  publication-title: Curr Opin Rheumatol
  doi: 10.1097/01.bor.0000240366.54960.a1
  contributor:
    fullname: Lafeber
– volume: 14
  start-page: 13
  issue: 1
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib22
  article-title: Osteoarthritis cartilage histopathology: grading and staging
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2005.07.014
  contributor:
    fullname: Pritzker
– volume: 33
  start-page: 635
  issue: 6
  year: 2009
  ident: 10.1016/j.jot.2020.05.001_bib78
  article-title: The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study
  publication-title: Int J Obes (Lond)
  doi: 10.1038/ijo.2009.62
  contributor:
    fullname: Stenholm
– volume: 63
  start-page: 991
  issue: 7
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib64
  article-title: Association of pain with frequency and magnitude of knee loading in knee osteoarthritis
  publication-title: Arthritis Care Res
  doi: 10.1002/acr.20476
  contributor:
    fullname: Robbins
– volume: 48
  start-page: 1290
  issue: 10
  year: 2009
  ident: 10.1016/j.jot.2020.05.001_bib23
  article-title: Cartilage defects are associated with physical disability in obese adults
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/kep246
  contributor:
    fullname: Anandacoomarasamy
– volume: 37
  start-page: 1238
  issue: 9
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib47
  article-title: Relationship of age and body mass index to the expression of obesity and osteoarthritis-related genes in human meniscus
  publication-title: Int J Obes (Lond)
  doi: 10.1038/ijo.2012.221
  contributor:
    fullname: Rai
– year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib11
  contributor:
    fullname: Practitioners RACoG
– volume: 26
  start-page: 1666
  issue: 12
  year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib42
  article-title: Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2018.08.006
  contributor:
    fullname: Landsmeer
– volume: 22
  start-page: 912
  issue: 7
  year: 2014
  ident: 10.1016/j.jot.2020.05.001_bib59
  article-title: Influences of alignment and obesity on knee joint loading in osteoarthritic gait
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2014.05.013
  contributor:
    fullname: Messier
– volume: 21
  start-page: 1660
  issue: 11
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib123
  article-title: Sustained clinical and structural benefit after joint distraction in the treatment of severe knee osteoarthritis
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2013.08.006
  contributor:
    fullname: Wiegant
– volume: 21
  start-page: 2
  issue: 4, Supplement
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib116
  article-title: Evaluation of off-loading braces for treatment of unicompartmental knee arthrosis
  publication-title: J Arthroplasty
  doi: 10.1016/j.arth.2006.02.099
  contributor:
    fullname: Dennis
– volume: 475
  start-page: 137
  issue: 1
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib133
  article-title: Do stemmed tibial components in total knee arthroplasty improve outcomes in patients with obesity?
  publication-title: Clin Orthop Relat Res
  doi: 10.1007/s11999-016-4791-6
  contributor:
    fullname: Parratte
– volume: 24
  start-page: 644
  issue: 3
  year: 2016
  ident: 10.1016/j.jot.2020.05.001_bib13
  article-title: Osteoarthritis in morbidly obese children and adolescents, an age-matched controlled study
  publication-title: Knee Surg Sports Traumatol Arthrosc
  doi: 10.1007/s00167-014-3068-4
  contributor:
    fullname: Widhalm
– volume: 89
  start-page: 2398
  issue: 11
  year: 2007
  ident: 10.1016/j.jot.2020.05.001_bib113
  article-title: A mechanical theory for the effectiveness of bracing for medial compartment osteoarthritis of the knee
  publication-title: J Bone Joint Surg Am
  doi: 10.2106/00004623-200711000-00009
  contributor:
    fullname: Ramsey
– volume: 14
  start-page: 777
  issue: 8
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib118
  article-title: Brace treatment for osteoarthritis of the knee: a prospective randomized multi-centre trial
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2006.02.004
  contributor:
    fullname: Brouwer
– volume: 7
  start-page: 3451
  issue: 1
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib43
  article-title: IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-03759-w
  contributor:
    fullname: Pearson
– volume: 55
  start-page: 690
  issue: 5
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib107
  article-title: Effects of strength training on the incidence and progression of knee osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.22245
  contributor:
    fullname: Mikesky
– volume: 66
  start-page: 158
  issue: 2
  year: 2007
  ident: 10.1016/j.jot.2020.05.001_bib67
  article-title: Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2006.053538
  contributor:
    fullname: Reijman
– volume: 108
  start-page: 193
  year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib16
  article-title: Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis
  publication-title: Bone
  doi: 10.1016/j.bone.2018.01.012
  contributor:
    fullname: Muratovic
– volume: 25
  start-page: 1299
  issue: 8
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib46
  article-title: Baseline meniscal extrusion associated with incident knee osteoarthritis after 30 months in overweight and obese women
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2017.03.014
  contributor:
    fullname: van der Voet
– volume: 83
  start-page: 1187
  issue: 9
  year: 2002
  ident: 10.1016/j.jot.2020.05.001_bib106
  article-title: The effect of dynamic versus isometric resistance training on pain and functioning among adults with osteoarthritis of the knee
  publication-title: Arch Phys Med Rehabil
  doi: 10.1053/apmr.2002.33988
  contributor:
    fullname: Topp
– volume: 34
  start-page: 1941
  issue: 11
  year: 2016
  ident: 10.1016/j.jot.2020.05.001_bib52
  article-title: Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading
  publication-title: J Orthop Res Off Publ Orthop Res Soc
  doi: 10.1002/jor.23204
  contributor:
    fullname: Ko
– volume: 74
  start-page: 1164
  issue: 6
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib109
  article-title: A randomised trial of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesions
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2014-206376
  contributor:
    fullname: Callaghan
– volume: 50
  start-page: 3904
  issue: 12
  year: 2004
  ident: 10.1016/j.jot.2020.05.001_bib71
  article-title: The effect of body weight on progression of knee osteoarthritis is dependent on alignment
  publication-title: Arthritis Rheum
  doi: 10.1002/art.20726
  contributor:
    fullname: Felson
– volume: 77
  start-page: 875
  issue: 6
  year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib4
  article-title: Intramuscular glucocorticoid injection versus placebo injection in hip osteoarthritis: a 12-week blinded randomised controlled trial
  publication-title: Ann Rheum Dis
  contributor:
    fullname: Dorleijn
– volume: 134
  start-page: 541
  issue: 7
  year: 2001
  ident: 10.1016/j.jot.2020.05.001_bib36
  article-title: The association of bone marrow lesions with pain in knee osteoarthritis
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-134-7-200104030-00007
  contributor:
    fullname: Felson
– volume: 20
  start-page: 423
  issue: 3
  year: 2012
  ident: 10.1016/j.jot.2020.05.001_bib66
  article-title: Biomechanical considerations in the pathogenesis of osteoarthritis of the knee
  publication-title: Knee Surg Sports Traumatol Arthrosc Offic J ESSKA
  doi: 10.1007/s00167-011-1818-0
  contributor:
    fullname: Heijink
– volume: 90
  start-page: 247
  issue: 3
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib119
  article-title: Efficacy of knee braces and foot orthoses in conservative management of knee osteoarthritis: a systematic review
  publication-title: Am J Phys Med Rehabil
  doi: 10.1097/PHM.0b013e318206386b
  contributor:
    fullname: Raja
– volume: 24
  start-page: 1126
  issue: 7
  year: 2016
  ident: 10.1016/j.jot.2020.05.001_bib95
  article-title: Progression of cartilage degeneration and clinical symptoms in obese and overweight individuals is dependent on the amount of weight loss: 48-month data from the Osteoarthritis Initiative
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2016.01.984
  contributor:
    fullname: Gersing
– volume: 141
  start-page: 208
  issue: 3
  year: 2003
  ident: 10.1016/j.jot.2020.05.001_bib30
  article-title: Characteristics of mineral particles in the human bone/cartilage interface
  publication-title: J Struct Biol
  doi: 10.1016/S1047-8477(02)00635-4
  contributor:
    fullname: Zizak
– volume: 43
  start-page: 3093
  issue: 12
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib37
  article-title: The influence of joint loading on bone marrow lesions in the knee: a systematic review with meta-analysis
  publication-title: Am J Sports Med
  doi: 10.1177/0363546514565092
  contributor:
    fullname: Beckwee
– volume: 71
  start-page: 232
  issue: 2
  year: 2019
  ident: 10.1016/j.jot.2020.05.001_bib83
  article-title: Risk of knee osteoarthritis with obesity, sarcopenic obesity, and sarcopenia
  publication-title: Arthrit Rheumatol
  doi: 10.1002/art.40692
  contributor:
    fullname: Misra
– volume: 35
  start-page: 1653
  issue: 8
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib15
  article-title: BMI-related microstructural changes in the tibial subchondral trabecular bone of patients with knee osteoarthritis
  publication-title: J Orthop Res : Offic Publ Orthop Res Soc
  doi: 10.1002/jor.23459
  contributor:
    fullname: Reina
– volume: 88
  start-page: 1336
  issue: 11
  year: 2008
  ident: 10.1016/j.jot.2020.05.001_bib80
  article-title: Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function
  publication-title: Phys Ther
  doi: 10.2522/ptj.20080079
  contributor:
    fullname: Hilton
– volume: 13
  start-page: 350
  issue: 2
  year: 2005
  ident: 10.1016/j.jot.2020.05.001_bib24
  article-title: Knee structural alteration and BMI: a cross-sectional study
  publication-title: Obes Res
  doi: 10.1038/oby.2005.47
  contributor:
    fullname: Ding
– volume: 310
  start-page: 1263
  issue: 12
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib92
  article-title: Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial
  publication-title: JAMA
  doi: 10.1001/jama.2013.277669
  contributor:
    fullname: Messier
– volume: 21
  start-page: 10
  issue: 1
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib9
  article-title: Osteoarthritis as a disease of mechanics
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2012.09.012
  contributor:
    fullname: Felson
– volume: 14
  start-page: 190
  issue: 2
  year: 2006
  ident: 10.1016/j.jot.2020.05.001_bib128
  article-title: Factors that influence high tibial osteotomy results in patients with medial gonarthritis: a score to predict the results
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2005.08.013
  contributor:
    fullname: Spahn
– volume: 15
  start-page: 1437
  issue: 12
  year: 2007
  ident: 10.1016/j.jot.2020.05.001_bib31
  article-title: A study of the prevalence and associations of subchondral bone marrow lesions in the knees of healthy, middle-aged women
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2007.04.010
  contributor:
    fullname: Guymer
– volume: 284
  start-page: 508
  issue: 2
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib96
  article-title: Is weight loss associated with less progression of changes in knee articular cartilage among obese and overweight patients as assessed with MR imaging over 48 Months? Data from the osteoarthritis initiative
  publication-title: Radiology
  doi: 10.1148/radiol.2017161005
  contributor:
    fullname: Gersing
– volume: 65
  start-page: 1569
  issue: 6
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib51
  article-title: In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae
  publication-title: Arthritis Rheum
  doi: 10.1002/art.37906
  contributor:
    fullname: Ko
– volume: 59
  start-page: 603
  issue: 5
  year: 2008
  ident: 10.1016/j.jot.2020.05.001_bib121
  article-title: Effectiveness of medial-wedge insole treatment for valgus knee osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.23560
  contributor:
    fullname: Rodrigues
– volume: 22
  start-page: 143
  issue: 3
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib26
  article-title: Macrophage-specific metalloelastase (MMP-12) immunoexpression in the osteochondral unit in osteoarthritis correlates with BMI and disease severity
  publication-title: Pathophysiology
  doi: 10.1016/j.pathophys.2015.06.001
  contributor:
    fullname: Kaspiris
– volume: 25
  start-page: 694
  issue: 5
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib45
  article-title: Factors associated with meniscal body extrusion on knee MRI in overweight and obese women
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2016.12.001
  contributor:
    fullname: Zhang
– volume: 317
  start-page: 1967
  issue: 19
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib5
  article-title: Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial
  publication-title: JAMA
  doi: 10.1001/jama.2017.5283
  contributor:
    fullname: McAlindon
– volume: 54
  start-page: 588
  issue: 4
  year: 2014
  ident: 10.1016/j.jot.2020.05.001_bib12
  article-title: Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis
  publication-title: Rheumatology
  contributor:
    fullname: van Caam
– volume: 175
  start-page: 923
  issue: 6
  year: 2015
  ident: 10.1016/j.jot.2020.05.001_bib6
  article-title: Evaluation of the benefit of corticosteroid injection before exercise therapy in patients with osteoarthritis of the knee: a randomized clinical trial
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2015.0461
  contributor:
    fullname: Henriksen
– volume: 51
  start-page: 204
  issue: 2
  year: 2012
  ident: 10.1016/j.jot.2020.05.001_bib28
  article-title: Osteochondral alterations in osteoarthritis
  publication-title: Bone
  doi: 10.1016/j.bone.2011.10.010
  contributor:
    fullname: Suri
– volume: 52
  start-page: 2026
  issue: 7
  year: 2005
  ident: 10.1016/j.jot.2020.05.001_bib85
  article-title: Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.21139
  contributor:
    fullname: Messier
– volume: 65
  start-page: 2615
  issue: 10
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib25
  article-title: High body mass index is associated with increased diurnal strains in the articular cartilage of the knee
  publication-title: Arthritis Rheum
  doi: 10.1002/art.38062
  contributor:
    fullname: Widmyer
– volume: 28
  start-page: 873
  issue: 7
  year: 2010
  ident: 10.1016/j.jot.2020.05.001_bib117
  article-title: Changes in knee adduction moment, pain, and functionality with a variable-stiffness walking shoe after 6 months
  publication-title: J Orthop Res
  doi: 10.1002/jor.21077
  contributor:
    fullname: Erhart
– volume: 39
  start-page: 64
  issue: 1
  year: 2010
  ident: 10.1016/j.jot.2020.05.001_bib126
  article-title: Long-term survival of high tibial osteotomy for medial compartment osteoarthritis of the knee
  publication-title: Am J Sports Med
  doi: 10.1177/0363546510377445
  contributor:
    fullname: Hui
– volume: 8
  start-page: e017689
  issue: 2
  year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib130
  article-title: Can obesity and physical activity predict outcomes of elective knee or hip surgery due to osteoarthritis? A meta-analysis of cohort studies
  publication-title: BMJ open
  doi: 10.1136/bmjopen-2017-017689
  contributor:
    fullname: Pozzobon
– volume: 29
  start-page: 675
  issue: 4
  year: 2003
  ident: 10.1016/j.jot.2020.05.001_bib33
  article-title: Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis?
  publication-title: Rheum Dis Clin N Am
  doi: 10.1016/S0889-857X(03)00061-9
  contributor:
    fullname: Burr
– volume: 22
  start-page: 639
  issue: 5
  year: 2014
  ident: 10.1016/j.jot.2020.05.001_bib90
  article-title: Structural changes in the knee during weight loss maintenance after a significant weight loss in obese patients with osteoarthritis: a report of secondary outcome analyses from a randomized controlled trial
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2014.03.003
  contributor:
    fullname: Henriksen
– volume: 14
  start-page: 513
  issue: 9
  year: 2018
  ident: 10.1016/j.jot.2020.05.001_bib81
  article-title: Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/s41574-018-0062-9
  contributor:
    fullname: Batsis
– volume: 12
  start-page: 632
  issue: 11
  year: 2016
  ident: 10.1016/j.jot.2020.05.001_bib20
  article-title: Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk
  publication-title: Nat Rev Rheumatol
  doi: 10.1038/nrrheum.2016.148
  contributor:
    fullname: Goldring
– volume: 51
  start-page: 249
  issue: 2
  year: 2012
  ident: 10.1016/j.jot.2020.05.001_bib40
  article-title: The role of synovitis in osteoarthritis pathogenesis
  publication-title: Bone
  doi: 10.1016/j.bone.2012.02.012
  contributor:
    fullname: Scanzello
– volume: 138
  start-page: 613
  issue: 8
  year: 2003
  ident: 10.1016/j.jot.2020.05.001_bib108
  article-title: Quadriceps strength and osteoarthritis progression in malaligned and lax knees
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-138-8-200304150-00006
  contributor:
    fullname: Sharma
– volume: 59
  start-page: 1207
  issue: 9
  year: 2008
  ident: 10.1016/j.jot.2020.05.001_bib2
  article-title: Lifetime risk of symptomatic knee osteoarthritis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.24021
  contributor:
    fullname: Murphy
– volume: 25
  start-page: 703
  issue: 10
  year: 2017
  ident: 10.1016/j.jot.2020.05.001_bib8
  article-title: Efficacy and treatment response of intra-articular corticosteroid injections in patients with symptomatic knee osteoarthritis
  publication-title: J Am Acad Orthop Surg
  doi: 10.5435/JAAOS-D-16-00541
  contributor:
    fullname: Matzkin
– volume: 70
  start-page: 1733
  issue: 10
  year: 2011
  ident: 10.1016/j.jot.2020.05.001_bib19
  article-title: Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study
  publication-title: Ann Rheum Dis
  doi: 10.1136/ard.2011.150052
  contributor:
    fullname: Englund
– volume: 310
  start-page: 1263
  issue: 12
  year: 2013
  ident: 10.1016/j.jot.2020.05.001_bib100
  article-title: Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the idea randomized clinical trial
  publication-title: JAMA
  doi: 10.1001/jama.2013.277669
  contributor:
    fullname: Messier
– volume: 327
  start-page: 607
  year: 2019
  ident: 10.1016/j.jot.2020.05.001_bib132
  article-title: The use of stems for morbid obesity in total knee arthroplasty
  publication-title: J Knee Surg
  contributor:
    fullname: Schultz
– volume: 88
  start-page: 180
  issue: 3
  year: 2009
  ident: 10.1016/j.jot.2020.05.001_bib60
  article-title: Weight, rather than obesity distribution, explains peak external knee adduction moment during level gait
  publication-title: Am J Phys Med Rehabil
  doi: 10.1097/PHM.0b013e318198b51b
  contributor:
    fullname: Segal
– volume: 123
  start-page: 1
  year: 2019
  ident: 10.1016/j.jot.2020.05.001_bib32
  article-title: Microcracks in subchondral bone plate is linked to less cartilage damage
  publication-title: Bone
  doi: 10.1016/j.bone.2019.03.011
  contributor:
    fullname: Zarka
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Snippet Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients’ quality of life. Whilst chronic...
Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause significant impact on patients' quality of life. Whilst chronic...
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SubjectTerms Biomechanics
Clinical management
Mechanical loading
Obesity
Osteoarthritis
Pathogenesis
Review
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Title Pathogenesis and clinical management of obesity-related knee osteoarthritis: Impact of mechanical loading
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