Dissection of Antibody Responses of Gam-COVID-Vac-Vaccinated Subjects Suggests Involvement of Epitopes Outside RBD in SARS-CoV-2 Neutralization

• Published in: International journal of molecular sciences Vol. 24; no. 6; p. 5104
• Main Authors: Byazrova, Maria, Gattinger, Pia, Astakhova, Ekaterina, Hofer, Gerhard, Khaitov, Musa, Filatov, Alexander, Valenta, Rudolf
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.03.2023; MDPI
• Subjects: Adenoviruses; Allergens; Antibodies; Antibodies, Neutralizing; Antibodies, Viral; antibody; Antibody Formation; Antigenic determinants; Antigens; Coronaviruses; COVID-19; COVID-19 vaccines; epitope; Epitopes; Gam-COVID-Vac; Health aspects; Humans; Immunoglobulin G; Infections; molecular interaction assay; Omicron; Pandemics; Peptides; Plasma; Protein Subunits; Proteins; SARS-CoV-2; SARS-CoV-2 - metabolism; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - metabolism; Surgery; Vaccination; Viral antibodies; Virus diseases; virus-neutralization; Austria; Germany; Russia; COVID-19; SARS-CoV-2; antibody; molecular interaction assay; Gam-COVID-Vac; virus-neutralization; Omicron; epitope

Millions of people have been vaccinated with Gam-COVID-Vac but fine specificities of induced antibodies have not been fully studied. Plasma from 12 naïve and 10 coronavirus disease 2019 (COVID-19) convalescent subjects was obtained before and after two immunizations with Gam-COVID-Vac. Antibody reac...