Co-Amorphization, Dissolution, and Stability of Quench-Cooled Drug–Drug Coamorphous Supersaturating Delivery Systems with RT-Unstable Amorphous Components

• Published in: Pharmaceutics Vol. 16; no. 12; p. 1488
• Main Authors: Zhang, Yan-Fei, Yao, Qian, Lin, Xiao-Ying, Ma, Ying-Hui, Zhang, Hui-Feng, Yu, Huan, Mu, Shang-Qiang, Zhang, Chuang, Geng, Hao, Hao, Cheng-Yi, Zuo, Li-Li, Wu, Di, Li, Yue, Jin, Li-Li, Shi, Nian-Qiu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024
• Subjects: Bioavailability; coamorphization and stability; combination therapy; Cooling; Crystallization; Drug delivery systems; Drug therapy, Combination; Drugs; Football (College); Free electron lasers; Pharmaceuticals; quench cooling; Quenching; Spectrum analysis; supersaturating drug delivery systems (SDDS); Vehicles; “drug–drug” coamorphous system (ddCAM); China; supersaturating drug delivery systems (SDDS); “drug–drug” coamorphous system (ddCAM); combination therapy; coamorphization and stability; quench cooling

Background: Supersaturating drug delivery systems (SDDSs) have gained significant attention as a promising strategy to enhance the solubility and bioabsorption of Biopharmaceutics Classification System (BCS) II drugs. To overcome challenges associated with polymer-based amorphous SDDS (aSDDS), coamo...