SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

• Published in: Nature communications Vol. 12; no. 1; pp. 4678 - 14
• Main Authors: Cohen, Carolyn A., Li, Athena P. Y., Hachim, Asmaa, Hui, David S. C., Kwan, Mike Y. W., Tsang, Owen T. Y., Chiu, Susan S., Chan, Wai Hung, Yau, Yat Sun, Kavian, Niloufar, Ma, Fionn N. L., Lau, Eric H. Y., Cheng, Samuel M. S., Poon, Leo L. M., Peiris, Malik, Valkenburg, Sophie A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.07.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/21; 13/31; 631/250/2152/1566; 631/250/255/2514; Adults; Antibodies; CD4 antigen; CD8 antigen; Cell activation; Children; Coronaviruses; COVID-19; Cytokines; Humanities and Social Sciences; Immune system; Immunity; Immunological memory; Immunology; Infections; Inflammation; Lymphocytes; Lymphocytes T; Memory cells; Monocytes; multidisciplinary; Ordination; Pathogenesis; Proteins; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Viral diseases

SARS-CoV-2 infection of children leads to a mild illness and the immunological differences with adults are unclear. Here, we report SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4 + T cell responses to structural SARS-CoV-2 proteins increas...