A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone

• Published in: Cancer letters Vol. 604; p. 217245
• Main Authors: Haab, Brian, Qian, Lu, Staal, Ben, Jain, Maneesh, Fahrmann, Johannes, Worthington, Christine, Prosser, Denise, Velokokhatnaya, Liudmila, Lopez, Camden, Tang, Runlong, Hurd, Mark W., Natarajan, Gopalakrishnan, Kumar, Sushil, Smith, Lynette, Hanash, Sam, Batra, Surinder K., Maitra, Anirban, Lokshin, Anna, Huang, Ying, Brand, Randall E.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.11.2024
• Subjects: Aged; Antigens, Tumor-Associated, Carbohydrate - blood; Biomarkers; Biomarkers, Tumor - blood; CA 19–9; CA-19-9 Antigen - blood; Carcinoma, Pancreatic Ductal - blood; Carcinoma, Pancreatic Ductal - diagnosis; Carcinoma, Pancreatic Ductal - pathology; Case-Control Studies; Early detection; Female; Humans; Male; Middle Aged; Pancreatic adenocarcinoma; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - pathology; Panel; Sensitivity and Specificity; Pancreatic adenocarcinoma; Biomarkers; Panel; CA 19–9; Early detection

A blood test that enables surveillance for early-stage pancreatic ductal adenocarcinoma (PDAC) is an urgent need. Independent laboratories have reported PDAC biomarkers that could improve biomarker performance over CA19-9 alone, but the performance of the previously reported biomarkers in combinatio...