Rational thresholding of circulating tumor DNA concentration for improved surveillance of metastatic breast cancer

• Published in: ESMO open Vol. 9; no. 2; p. 102235
• Main Authors: Martens, G.A., Demol, J., Dedeurwaerdere, F., Breyne, J., De Smet, K., De Jaeger, P., De Smet, D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2024; Elsevier
• Subjects: Biomarkers, Tumor - genetics; Breast Neoplasms - drug therapy; CA15-3; cancer surveillance; circulating tumor DNA; Circulating Tumor DNA - genetics; Class I Phosphatidylinositol 3-Kinases - genetics; Disease Progression; Female; Humans; liquid biopsy; metastatic breast cancer; molecular relapse; Original Research; cancer surveillance; molecular relapse; liquid biopsy; CA15-3; metastatic breast cancer; circulating tumor DNA

The use of circulating tumor DNA (ctDNA) concentration for metastatic cancer surveillance is promising, but uncertainty remains about cut-offs with clinical validity. This observational study recruited 136 subjects with advanced metastatic breast cancer (irrespective of ERBB2/hormone receptor status...