Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets

• Published in: Cell death discovery Vol. 7; no. 1; p. 232
• Main Authors: DaSilva, Nicholas A., Barlock, Benjamin J., Guha, Prajna, Ghosh, Chandra C., Trebino, Catherine E., Camberg, Jodi L., Katz, Steven C., Rowley, David C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.09.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/154/555; 631/250/251/1574; 631/45/475; 631/67/327; Apoptosis; Biochemistry; Biomedical and Life Sciences; CD11b antigen; Cell Biology; Cell Cycle Analysis; Drug development; Hepatocytes; Immunotherapy; Life Sciences; Liver; Lung cancer; Metastases; Metastasis; Protein interaction; Proteins; Proteomes; Proteomics; Stem Cells; Suppressor cells; Tumor microenvironment; Tumors

Myeloid-derived suppressor cells (MDSCs) promote immunosuppressive activities in the tumor microenvironment (TME), resulting in increased tumor burden and diminishing the anti-tumor response of immunotherapies. While primary and metastatic tumors are typically the focal points of therapeutic develop...