Functional assessment of spermatogonial stem cell purity in experimental cell populations

• Published in: Stem cell research Vol. 29; pp. 129 - 133
• Main Authors: Lord, Tessa, Oatley, Jon M.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.05.2018; Elsevier
• Subjects: Animals; Limiting dilution; Male; Mice; Spermatogonia - metabolism; Spermatogonial stem cell; Stem Cell Transplantation - methods; Stem Cells - metabolism; Transplantation; Limiting dilution; Spermatogonial stem cell; Transplantation

Historically, research in spermatogonial biology has been hindered by a lack of validated approaches to identify and isolate pure populations of the various spermatogonial subsets for in-depth analysis. In particular, although a number of markers of the undifferentiated spermatogonial population hav...