Pathological and immunological features of canine necrotising meningoencephalitis and granulomatous meningoencephalitis

• Published in: The Veterinary Journal Vol. 213; pp. 72 - 77
• Main Authors: Uchida, Kazuyuki, Park, Eunsil, Tsuboi, Masaya, Chambers, James K., Nakayama, Hiroyuki
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2016; Elsevier BV
• Subjects: Animals; astrocytes; autoantibodies; blood vessels; Canine; chemokines; cortex; Dog Diseases; Dog Diseases - etiology; Dog Diseases - immunology; Dog Diseases - pathology; Dogs; Granuloma; Granuloma - etiology; Granuloma - immunology; Granuloma - pathology; Granuloma - veterinary; Granulomatous meningoencephalitis; Immune response; lymphocytes; macrophages; meninges; Meningoencephalitis; Meningoencephalitis - etiology; Meningoencephalitis - immunology; Meningoencephalitis - pathology; Meningoencephalitis - veterinary; Necrosis; Necrosis - etiology; Necrosis - immunology; Necrosis - pathology; Necrosis - veterinary; Necrotising leucoencephalitis; Necrotising meningoencephalitis; pathogenesis; phenotype; risk factors; vaccination; Yorkshire Terrier; Necrotising meningoencephalitis; Necrotising leucoencephalitis; Granulomatous meningoencephalitis; Immune response; Canine

•Necrotising meningoencephalitis (NME) can be divided into cortex dominant and white matter dominant types.•Lesions in granulomatous meningoencephalitis (GME) are characterised by granulomas with infiltration by T lymphocytes.•Autoantibodies against astrocytes are detected predominantly in NME.•Diff...