Asymmetric biomimetic transamination of α-keto amides to peptides

• Published in: Nature communications Vol. 12; no. 1; pp. 5174 - 9
• Main Authors: Cai, Weiqi, Qiao, Xuelong, Zhang, Hao, Li, Bo, Guo, Jianhua, Zhang, Liangliang, Chen, Wen-Wen, Zhao, Baoguo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/77/883; 639/638/77/889; Amides; Amino acids; Asymmetry; Biological activity; Biomimetic materials; Biomimetics; Catalysts; Enantiomers; Humanities and Social Sciences; multidisciplinary; Peptides; Science; Science (multidisciplinary); Transaminases

Peptides are important compounds with broad applications in many areas. Asymmetric transamination of α-keto amides can provide an efficient strategy to synthesize peptides, however, the process has not been well developed yet and still remains a great challenge in both enzymatic and catalytic chemis...