Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection

• Published in: eLife Vol. 8
• Main Authors: Matty, Molly A, Knudsen, Daphne R, Walton, Eric M, Beerman, Rebecca W, Cronan, Mark R, Pyle, Charlie J, Hernandez, Rafael E, Tobin, David M
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 29.01.2019; eLife Sciences Publications, Ltd
• Subjects: Animals; Anti-Allergic Agents - pharmacology; Antibiotics; Antitubercular Agents - pharmacology; Calcium; Calcium - immunology; Calcium - metabolism; Cell culture; Clemastine - pharmacology; Clinical trials; Danio rerio; Disease Models, Animal; Drug Repositioning; Drug resistance; Experiments; Gene Expression Regulation; Genomics; Granuloma - drug therapy; Granuloma - genetics; Granuloma - immunology; Granuloma - microbiology; host-directed therapies; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Immunity, Innate - drug effects; Immunology and Inflammation; Infections; Inflammasomes; Larva - drug effects; Larva - genetics; Larva - immunology; Larva - microbiology; Larvae; light sheet microscopy; Light therapy; Macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - microbiology; Medical research; Microbiology and Infectious Disease; Mutation; mycobacterium; Mycobacterium Infections, Nontuberculous - drug therapy; Mycobacterium Infections, Nontuberculous - genetics; Mycobacterium Infections, Nontuberculous - immunology; Mycobacterium Infections, Nontuberculous - microbiology; Mycobacterium marinum - growth & development; Mycobacterium marinum - immunology; Mycobacterium marinum - pathogenicity; Mycobacterium tuberculosis - pathogenicity; p2rx7; phenotypic drug screening; Public health; Receptors, Purinergic P2X7 - genetics; Receptors, Purinergic P2X7 - immunology; Signal Transduction; Tissue Culture Techniques; Tuberculosis; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - microbiology; zebrafish; Zebrafish - genetics; Zebrafish - immunology; Zebrafish - microbiology; Zebrafish Proteins - agonists; Zebrafish Proteins - genetics; Zebrafish Proteins - immunology; United States > US; mycobacterium; infectious disease; inflammation; host-directed therapies; microbiology; zebrafish; phenotypic drug screening; immunology; light sheet microscopy; p2rx7

is the leading worldwide cause of death due to a single infectious agent. Existing anti-tuberculous therapies require long treatments and are complicated by multi-drug-resistant strains. Host-directed therapies have been proposed as an orthogonal approach, but few have moved into clinical trials. He...