A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

• Published in: The Journal of experimental medicine Vol. 210; no. 10; pp. 2071 - 2086
• Main Authors: Braun, Laurence, Brenier-Pinchart, Marie-Pierre, Yogavel, Manickam, Curt-Varesano, Aurélie, Curt-Bertini, Rose-Laurence, Hussain, Tahir, Kieffer-Jaquinod, Sylvie, Coute, Yohann, Pelloux, Hervé, Tardieux, Isabelle, Sharma, Amit, Belrhali, Hassan, Bougdour, Alexandre, Hakimi, Mohamed-Ali
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 23.09.2013; The Rockefeller University Press
• Subjects: Amino Acid Motifs; Amino Acid Sequence; Animals; Biochemistry, Molecular Biology; Cell Line; Cell Nucleus - metabolism; Chemokines - biosynthesis; Cluster Analysis; Early Growth Response Protein 1 - genetics; Early Growth Response Protein 1 - metabolism; Enzyme Activation; Female; Gene Deletion; Gene Expression Profiling; Gene Order; Genomics; Humans; Inflammation - genetics; Inflammation - immunology; Life Sciences; Macrophages - immunology; Macrophages - metabolism; Mice; Models, Molecular; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases - chemistry; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Transport; Proto-Oncogene Proteins c-fos - genetics; Proto-Oncogene Proteins c-fos - metabolism; Protozoan Proteins - chemistry; Protozoan Proteins - genetics; Protozoan Proteins - immunology; Protozoan Proteins - metabolism; Sequence Alignment; Toxoplasma - genetics; Toxoplasma - immunology; Toxoplasma gondii; Toxoplasmosis - immunology; Toxoplasmosis - metabolism

Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response....