A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation - Braun, Laurence; Brenier-Pinchart, Marie-Pierre; Yogavel, Manickam; Curt-Varesano, Aurélie; Curt-Bertini, Rose-Laurence; Hussain, Tahir; Kieffer-Jaquinod, Sylvie; Coute, Yohann; Pelloux, Hervé; Tardieux, Isabelle; Sharma, Amit; Belrhali, Hassan; et al. (The Journal of experimental medicine, 2013)
Keywords: Amino Acid Motifs; Amino Acid Sequence; Animals; Biochemistry, Molecular Biology; Cell Line; Cell Nucleus - metabolism; Chemokines - biosynthesis; Cluster Analysis; Early Growth Response Protein 1 - genetics; Early Growth Response Protein 1 - metabolism; Enzyme Activation; Female; Gene Deletion; Gene Expression Profiling; Gene Order; Genomics; Humans; Inflammation - genetics; Inflammation - immunology; Life Sciences; Macrophages - immunology; Macrophages - metabolism; Mice; Models, Molecular; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases - chemistry; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Transport; Proto-Oncogene Proteins c-fos - genetics; Proto-Oncogene Proteins c-fos - metabolism; Protozoan Proteins - chemistry; Protozoan Proteins - genetics; Protozoan Proteins - immunology; Protozoan Proteins - metabolism; Sequence Alignment; Toxoplasma - genetics; Toxoplasma - immunology; Toxoplasma gondii; Toxoplasmosis - immunology; Toxoplasmosis - metabolism