Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer – a matched-pair study
The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PC...
Saved in:
| Published in | Reproductive biomedicine online Vol. 35; no. 5; pp. 576 - 582 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.11.2017
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed. Clinical pregnancy, early miscarriage and live birth rates were compared. Logistic regression analysis was performed to further evaluate the factors associated with early miscarriage and live birth. Clinical pregnancy rates were 50.7% in PCOS and 55.2% in control groups. Early miscarriage rate was significantly (P = 0.029) increased in the PCOS group compared with controls; non-PCOS patients had a significantly higher live birth rate than PCOS patients, P < 0.001. Further regression analyses showed that PCOS was significantly associated with a higher risk of early miscarriage and decreased chance of live birth. In conclusion, PCOS in women undergoing pre-implantation genetic diagnosis may, independently from BMI and karyotype, increase the risk of miscarriage. |
|---|---|
| AbstractList | The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed. Clinical pregnancy, early miscarriage and live birth rates were compared. Logistic regression analysis was performed to further evaluate the factors associated with early miscarriage and live birth. Clinical pregnancy rates were 50.7% in PCOS and 55.2% in control groups. Early miscarriage rate was significantly (P = 0.029) increased in the PCOS group compared with controls; non-PCOS patients had a significantly higher live birth rate than PCOS patients, P < 0.001. Further regression analyses showed that PCOS was significantly associated with a higher risk of early miscarriage and decreased chance of live birth. In conclusion, PCOS in women undergoing pre-implantation genetic diagnosis may, independently from BMI and karyotype, increase the risk of miscarriage. The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed. Clinical pregnancy, early miscarriage and live birth rates were compared. Logistic regression analysis was performed to further evaluate the factors associated with early miscarriage and live birth. Clinical pregnancy rates were 50.7% in PCOS and 55.2% in control groups. Early miscarriage rate was significantly (P = 0.029) increased in the PCOS group compared with controls; non-PCOS patients had a significantly higher live birth rate than PCOS patients, P < 0.001. Further regression analyses showed that PCOS was significantly associated with a higher risk of early miscarriage and decreased chance of live birth. In conclusion, PCOS in women undergoing pre-implantation genetic diagnosis may, independently from BMI and karyotype, increase the risk of miscarriage.The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed. Clinical pregnancy, early miscarriage and live birth rates were compared. Logistic regression analysis was performed to further evaluate the factors associated with early miscarriage and live birth. Clinical pregnancy rates were 50.7% in PCOS and 55.2% in control groups. Early miscarriage rate was significantly (P = 0.029) increased in the PCOS group compared with controls; non-PCOS patients had a significantly higher live birth rate than PCOS patients, P < 0.001. Further regression analyses showed that PCOS was significantly associated with a higher risk of early miscarriage and decreased chance of live birth. In conclusion, PCOS in women undergoing pre-implantation genetic diagnosis may, independently from BMI and karyotype, increase the risk of miscarriage. |
| Author | Zhou, Canquan Luo, Lu Gu, Fang Zhao, Qiang Wang, Qiong Jie, Huying Ding, Chenhui |
| Author_xml | – sequence: 1 givenname: Lu surname: Luo fullname: Luo, Lu organization: The Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, and Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong, China – sequence: 2 givenname: Fang surname: Gu fullname: Gu, Fang organization: The Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, and Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong, China – sequence: 3 givenname: Huying surname: Jie fullname: Jie, Huying organization: The Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, and Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong, China – sequence: 4 givenname: Chenhui surname: Ding fullname: Ding, Chenhui organization: The Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, and Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong, China – sequence: 5 givenname: Qiang surname: Zhao fullname: Zhao, Qiang organization: Department of Obstetrics and Gynecology, Jiangmen Central Hospital of Sun Yat-sen University, Guangdong, China – sequence: 6 givenname: Qiong surname: Wang fullname: Wang, Qiong organization: The Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, and Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong, China – sequence: 7 givenname: Canquan surname: Zhou fullname: Zhou, Canquan email: zhoucanquan@hotmail.com organization: The Centre of Reproductive Medicine, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University, and Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28802704$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkcuKFTEQhoOMOBd9AReSpZs-JunTJ2lxI8N4gQE3ug65VDTHdNIm6ZHe-Q6-oU9iDmecxSxGKKpC-L-C-v9zdBJTBISeU7KhhO5e7TdZT2nDCOUb0oqSR-iMbjnrdtuRnty9RX-KzkvZE0IFEf0TdMqEIIyT7RlarlQOK558MSpnr74CzqoC9hEHUBHPKaxmLdUbnG5UXnFZo81pAvyztYiVq5AxLHNI3mKYdF4TrlnF4tr_n1-_scKTquYb2G5WPuNSF7s-RY-dCgWe3c4L9OXd1efLD931p_cfL99ed2agvHY9wE4bp0frBi6MZa7vjRssNZwwPdJecS7AcaMGbcR2FEQrzRhoBqYHYfsL9PK4d87pxwKlysOhEIKKkJYi6cgEF8Nu4E364la66AmsnLOf2r3yn1VNwI4Ck1MpGdydhBJ5yEPu5SEPechDklaUNEjcg4yvqvoUm0c-PIy-OaLQDLrxkGUxHqIB6zOYKm3yD-Ov7-Em-OiNCt9h_R_8F5d8vao |
| CitedBy_id | crossref_primary_10_3390_ijerph18168253 crossref_primary_10_1186_s43043_024_00191_9 crossref_primary_10_1016_j_rbmo_2022_10_002 crossref_primary_10_3390_cancers14225572 crossref_primary_10_2147_DMSO_S393960 crossref_primary_10_1016_j_rbmo_2023_04_014 crossref_primary_10_1136_bmjopen_2021_051489 crossref_primary_10_3389_fendo_2021_799871 crossref_primary_10_1186_s12884_025_07342_4 crossref_primary_10_3389_fendo_2024_1275419 crossref_primary_10_1016_j_xfss_2020_12_001 crossref_primary_10_1080_01443615_2024_2338235 crossref_primary_10_3390_ijms22073789 crossref_primary_10_1093_hropen_hoae024 crossref_primary_10_1093_humrep_deab181 crossref_primary_10_1093_molehr_gaab067 crossref_primary_10_1007_s10815_020_01996_z crossref_primary_10_3389_fendo_2020_592495 crossref_primary_10_3389_fphar_2022_904942 crossref_primary_10_3390_pathophysiology31040041 crossref_primary_10_46989_001c_127965 crossref_primary_10_1111_1471_0528_16461 crossref_primary_10_1113_JP277879 crossref_primary_10_1016_j_jogoh_2022_102399 crossref_primary_10_1016_j_xagr_2024_100332 crossref_primary_10_1016_j_xfre_2020_05_006 crossref_primary_10_1016_j_xfnr_2024_100078 crossref_primary_10_1111_ajo_13213 crossref_primary_10_3390_jcm8081210 crossref_primary_10_1007_s00404_022_06757_0 crossref_primary_10_1016_j_rbmo_2024_104381 crossref_primary_10_1007_s10815_024_03235_1 crossref_primary_10_3390_jcm10102101 crossref_primary_10_1038_s41467_024_49749_1 crossref_primary_10_1016_j_xfnr_2022_03_001 crossref_primary_10_1093_humupd_dmad010 crossref_primary_10_1016_j_xfnr_2020_12_001 crossref_primary_10_2147_IJWH_S465541 crossref_primary_10_1016_j_tem_2023_02_002 crossref_primary_10_1186_s12958_024_01293_9 crossref_primary_10_1016_j_steroids_2022_108989 crossref_primary_10_1016_j_jri_2023_104155 crossref_primary_10_31083_j_ceog4902048 |
| Cites_doi | 10.1007/s10815-015-0488-0 10.2147/IJWH.S70314 10.7150/ijbs.13109 10.1016/S1472-6483(10)60037-5 10.1007/s10815-013-0069-z 10.1016/j.fertnstert.2009.03.021 10.4103/2229-516X.179024 10.1210/jc.2003-032046 10.1093/humupd/dmq032 10.1186/1756-9966-33-41 10.1093/humrep/deh098 10.1016/j.fertnstert.2006.12.018 10.1210/jc.2008-1612 10.1093/oxfordjournals.humrep.a138174 10.1093/humrep/dev055 10.1093/humrep/dep399 10.1056/NEJMoa1513873 10.1093/humrep/15.3.612 10.1055/s-2007-992925 10.1136/bmj.d6309 10.1016/j.fertnstert.2007.07.1290 10.1210/jc.2010-2600 10.2119/molmed.2009.00118 10.1016/S0015-0282(16)58026-1 10.1210/jc.2015-2682 10.1016/j.rbmo.2016.04.006 10.1186/1423-0127-21-2 10.1016/j.tem.2010.12.002 10.1097/GRF.0b013e318161719c 10.1186/s12884-015-0665-2 |
| ContentType | Journal Article |
| Copyright | 2017 Reproductive Healthcare Ltd. Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2017 Reproductive Healthcare Ltd. – notice: Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.rbmo.2017.07.010 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1472-6491 |
| EndPage | 582 |
| ExternalDocumentID | 28802704 10_1016_j_rbmo_2017_07_010 S1472648317303462 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 123 1B1 1P~ 1~. 1~5 29P 36B 4.4 457 4G. 53G 5VS 7-5 71M 8P~ AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABDBF ABFNM ABJNI ABMAC ABMZM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACRLP ACRPL ACUHS ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADVLN AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN B0M BKOJK BLXMC BNPGV DU5 EAP EBS EFJIC EFKBS EJD EMB EMK EMOBN ESX F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN GBLVA HVGLF HZ~ KOM M41 ML~ MO0 O-L O9- OAUVE OQ. OZT P-8 P-9 P2P PC. PH~ Q38 R2- ROL SDF SEL SES SJN SPCBC SSH SSZ SV3 T5K TUS XH2 Z5R ~8M ~G- 0SF AACTN AAIAV ABLVK ABYKQ AFCTW AFKWA AJBFU AJOXV AMFUW EFLBG LCYCR NCXOZ AAYXX AGRNS CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c517t-3ee6bcfb9df578cd2f33cf5d1c702b913a778ef7ca5bc84980bab22eb2ec3e8d3 |
| IEDL.DBID | .~1 |
| ISSN | 1472-6483 1472-6491 |
| IngestDate | Tue Aug 05 10:39:05 EDT 2025 Wed Feb 19 02:40:49 EST 2025 Thu Apr 24 23:11:02 EDT 2025 Tue Jul 01 01:53:54 EDT 2025 Fri Feb 23 02:29:21 EST 2024 Tue Aug 26 19:39:30 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | pre-implantation genetic diagnosis vitrified-warmed embryo transfer early miscarriage polycystic ovary syndrome |
| Language | English |
| License | Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c517t-3ee6bcfb9df578cd2f33cf5d1c702b913a778ef7ca5bc84980bab22eb2ec3e8d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.rbmojournal.com/article/S1472-6483(17)30346-2/pdf |
| PMID | 28802704 |
| PQID | 1928785657 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_1928785657 pubmed_primary_28802704 crossref_primary_10_1016_j_rbmo_2017_07_010 crossref_citationtrail_10_1016_j_rbmo_2017_07_010 elsevier_sciencedirect_doi_10_1016_j_rbmo_2017_07_010 elsevier_clinicalkey_doi_10_1016_j_rbmo_2017_07_010 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | November 2017 2017-11-00 2017-Nov 20171101 |
| PublicationDateYYYYMMDD | 2017-11-01 |
| PublicationDate_xml | – month: 11 year: 2017 text: November 2017 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Reproductive biomedicine online |
| PublicationTitleAlternate | Reprod Biomed Online |
| PublicationYear | 2017 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Balen, Tan, MacDougall, Jacobs (bib0020) 1993; 8 Gardner, Schoolcraft (bib0060) 1999 Roos, Kieler, Sahlin, Ekman-Ordeberg, Falconer, Stephansson (bib0140) 2011; 343 Warren, Silver (bib0170) 2008; 51 Qiao, Feng (bib0125) 2011; 17 Metwally, Ong, Ledger, Li (bib0105) 2008; 90 Sundvall, Kirkegaard, Ingerslev, DeMayo, Jeong, Hamilton, Giudice, Lessey (bib0160) 2015; 32 Asunción, Calvo, San Millán, Sancho, Avila, Escobar-Morreale (bib0010) 2000; 85 Kim, Song, Kim, Kang, Jun, Hong, Koong, Kim (bib0080) 2000; 94 Palomba, Santagni, Falbo, Sala (bib0115) 2015; 7 Rees, Jenkins-Jones, Morgan (bib0135) 2016; 101 Bruno, Burgess, Ren, Nouri, Pertile, Francis, Norris (bib0035) 2008; 15 Piltonen, Chen, Khatun, Kangasniemi, Liakka, Spitzer, Tran, Huddleston, Irwin, Giudice (bib0120) 2015; 30 (bib0145) 2004; 19 March, Moore, Willson (bib0100) 2010; 25 Jung, Park, Shin (bib0070) 2015; 15 Rai, Backos, Rushworth, Ekman-Ordeberg, Falconer, Stephansson (bib0130) 2000; 15 Weghofer, Munne, Chen, Barad, Gleicher (bib0175) 2007; 88 Savaris, Groll, Young (bib0150) 2011; 96 Li, Feng, Lin, Billig, Shao (bib0085) 2014; 21 Wang, Luo, Lei, Lin, Huang, Chen, Zeng, Zhou (bib0165) 2016; 33 Metwally, Saravelos, Ledger, Li (bib0110) 2010; 94 Kaur, Gupta (bib0075) 2016; 6 Li, Pishdari, Cui, Hu, Yang, Guo, Jiang, Feng, Billig, Shao (bib0090) 2015; 11 Mackinnon, Selan, Zordan, Wall, Nandurkar, Campbe (bib0095) 2012; 2 Cardozo, Pavone, Jennifer (bib0040) 2011; 22 Shao, Li, Feng (bib0155) 2014; 33 Fornes, Ormazabal, Rosas, Gabler, Vantman, Romero, Vega (bib0055) 2010; 16 Chen, Shi, Sun, Zhang, Liang, Cao, Yang, Liu, Wei, Weng, Tian, Hao, Yang, Zhou, Shi, Xu, Li, Yan, Qin, Zhao, Zhang, Legro (bib0045) 2016; 375 Dumesic, Abbott (bib0050) 2008; 26 Brezina, Mensah, Balen (bib0030) 2013; 30 Azziz, Woods, Reyna, Key, Knochenhauer, Yildiz (bib0015) 2004; 89 Beydoun, Stadtmauer, Beydou, Russell, Zhao, Oehninger (bib0025) 2009; 18 Hasegawa, Tanaka, Sanada, Imai, Fujimori (bib0065) 1996; 65 Qiao (10.1016/j.rbmo.2017.07.010_bib0125) 2011; 17 Dumesic (10.1016/j.rbmo.2017.07.010_bib0050) 2008; 26 Wang (10.1016/j.rbmo.2017.07.010_bib0165) 2016; 33 Mackinnon (10.1016/j.rbmo.2017.07.010_bib0095) 2012; 2 Rai (10.1016/j.rbmo.2017.07.010_bib0130) 2000; 15 Chen (10.1016/j.rbmo.2017.07.010_bib0045) 2016; 375 Sundvall (10.1016/j.rbmo.2017.07.010_bib0160) 2015; 32 Li (10.1016/j.rbmo.2017.07.010_bib0090) 2015; 11 Warren (10.1016/j.rbmo.2017.07.010_bib0170) 2008; 51 Cardozo (10.1016/j.rbmo.2017.07.010_bib0040) 2011; 22 Kim (10.1016/j.rbmo.2017.07.010_bib0080) 2000; 94 Azziz (10.1016/j.rbmo.2017.07.010_bib0015) 2004; 89 Metwally (10.1016/j.rbmo.2017.07.010_bib0105) 2008; 90 Shao (10.1016/j.rbmo.2017.07.010_bib0155) 2014; 33 Savaris (10.1016/j.rbmo.2017.07.010_bib0150) 2011; 96 Metwally (10.1016/j.rbmo.2017.07.010_bib0110) 2010; 94 Jung (10.1016/j.rbmo.2017.07.010_bib0070) 2015; 15 Rees (10.1016/j.rbmo.2017.07.010_bib0135) 2016; 101 Brezina (10.1016/j.rbmo.2017.07.010_bib0030) 2013; 30 Beydoun (10.1016/j.rbmo.2017.07.010_bib0025) 2009; 18 Piltonen (10.1016/j.rbmo.2017.07.010_bib0120) 2015; 30 Asunción (10.1016/j.rbmo.2017.07.010_bib0010) 2000; 85 Kaur (10.1016/j.rbmo.2017.07.010_bib0075) 2016; 6 Balen (10.1016/j.rbmo.2017.07.010_bib0020) 1993; 8 Weghofer (10.1016/j.rbmo.2017.07.010_bib0175) 2007; 88 Roos (10.1016/j.rbmo.2017.07.010_bib0140) 2011; 343 Li (10.1016/j.rbmo.2017.07.010_bib0085) 2014; 21 Palomba (10.1016/j.rbmo.2017.07.010_bib0115) 2015; 7 Gardner (10.1016/j.rbmo.2017.07.010_bib0060) 1999 Hasegawa (10.1016/j.rbmo.2017.07.010_bib0065) 1996; 65 (10.1016/j.rbmo.2017.07.010_bib0145) 2004; 19 Bruno (10.1016/j.rbmo.2017.07.010_bib0035) 2008; 15 March (10.1016/j.rbmo.2017.07.010_bib0100) 2010; 25 Fornes (10.1016/j.rbmo.2017.07.010_bib0055) 2010; 16 |
| References_xml | – volume: 25 start-page: 544 year: 2010 end-page: 551 ident: bib0100 article-title: The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria publication-title: Hum. Reprod – volume: 8 start-page: 959 year: 1993 end-page: 964 ident: bib0020 article-title: Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin publication-title: Hum. Reprod – volume: 22 start-page: 103 year: 2011 end-page: 109 ident: bib0040 article-title: Metabolic syndrome and oocyte quality publication-title: Trends Endocrinol. Metab – volume: 32 start-page: 1031 year: 2015 end-page: 1042 ident: bib0160 article-title: Unaltered timing of embryo development in women with polycystic ovarian syndrome (PCOS): a time-lapse study publication-title: J. Assist. Reprod. Genet – volume: 15 start-page: 2786 year: 2008 end-page: 2793 ident: bib0035 article-title: High-throughput analysis of chromosome abnormality in spontaneous miscarriage using an MLPA subtelomere assay with ancillary FISH test for polyploidy publication-title: Am. J. Med. Genet – volume: 7 start-page: 745 year: 2015 end-page: 763 ident: bib0115 article-title: Complications and challenges associated with polycystic ovary syndrome: current perspectives publication-title: Int. J. Womens Health – volume: 88 start-page: 900 year: 2007 end-page: 905 ident: bib0175 article-title: Lack of association between polycystic ovary syndrome and embryonic aneuploidy publication-title: Fertil. Steril – volume: 15 start-page: 228 year: 2015 ident: bib0070 article-title: Body mass index at age 18–20 and later risk of spontaneous abortion in the Health Examinees Study (HEXA) publication-title: BMC Pregnancy Childbirth – volume: 21 start-page: 2 year: 2014 ident: bib0085 article-title: Endometrial progesterone resistance and PCOS publication-title: J. Biomed. Sci – volume: 30 start-page: 1169 year: 2013 end-page: 1174 ident: bib0030 article-title: Fertility management in the PCOS population: results of a web-based survey at IVF-worldwide.com publication-title: J. Assist. Reprod. Genet – volume: 15 start-page: 612 year: 2000 end-page: 615 ident: bib0130 article-title: Polycystic ovaries and recurrent miscarriage – a reappraisal publication-title: Hum. Reprod – volume: 19 start-page: 41 year: 2004 end-page: 47 ident: bib0145 article-title: Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome (PCOS) publication-title: Hum. Reprod – volume: 30 start-page: 1203 year: 2015 end-page: 1215 ident: bib0120 article-title: Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration publication-title: Hum. Reprod – volume: 18 start-page: 856 year: 2009 end-page: 863 ident: bib0025 article-title: Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies publication-title: Reprod. Biomed. Online – volume: 26 start-page: 53 year: 2008 end-page: 61 ident: bib0050 article-title: Implications of Polycystic Ovary Syndrome (PCOS) on oocyte development publication-title: Semin. Reprod. Med – volume: 65 start-page: 52 year: 1996 end-page: 54 ident: bib0065 article-title: Studies on the cytogenetic and endocrinologic background of spontaneous abortion publication-title: Fertil. Steril – volume: 96 start-page: 1737 year: 2011 end-page: 1746 ident: bib0150 article-title: Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles publication-title: J. Clin. Endocrinol. Metab – volume: 94 start-page: 1416 year: 2000 end-page: 1426 ident: bib0080 article-title: Transcriptional profiling with a pathway-oriented analysis identifies dysregulated molecular phenotypes in the endometrium of patients with polycystic ovary syndrome publication-title: J. Clin. Endocrinol. Metab – volume: 343 start-page: d6309 year: 2011 ident: bib0140 article-title: Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study publication-title: BMJ – volume: 51 start-page: 84 year: 2008 end-page: 95 ident: bib0170 article-title: Genetics of pregnancy loss publication-title: Clin. Obstet. Gynecol – volume: 94 start-page: 290 year: 2010 end-page: 295 ident: bib0110 article-title: Body mass index and risk of miscarriage in women with recurrent miscarriage publication-title: Fertil. Steril – year: 1999 ident: bib0060 article-title: In-vitro culture of human blastocyst publication-title: Towards Reproductive Certainty: Infertility and Genetics Beyond – volume: 90 start-page: 714 year: 2008 end-page: 726 ident: bib0105 article-title: Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence publication-title: Fertil. Steril – volume: 11 start-page: 1376 year: 2015 end-page: 1389 ident: bib0090 article-title: Regulation of androgen receptor expression alters AMPK phosphorylation in the endometrium: publication-title: Int. J. Biol. Sci – volume: 89 start-page: 2745 year: 2004 end-page: 2749 ident: bib0015 article-title: The prevalence and features of the polycystic ovary syndrome in an unselected population publication-title: J. Clin. Endocrinol. Metab – volume: 85 start-page: 2434 year: 2000 end-page: 2438 ident: bib0010 article-title: A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain publication-title: J. Clin. Endocrinol. Metab – volume: 17 start-page: 17 year: 2011 end-page: 33 ident: bib0125 article-title: Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence publication-title: Hum. Reprod. Update – volume: 33 start-page: 85 year: 2016 end-page: 92 ident: bib0165 article-title: Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome publication-title: Reprod. Biomed. Online – volume: 6 start-page: 79 year: 2016 end-page: 83 ident: bib0075 article-title: Endocrine dysfunction and recurrent spontaneous abortion: an overview publication-title: Int. J. Appl. Basic Med. Res – volume: 375 start-page: 23 year: 2016 end-page: 33 ident: bib0045 article-title: Fresh versus frozen embryos for infertility in the polycystic ovary syndrome publication-title: N. Engl. J. Med – volume: 2 start-page: 5 year: 2012 end-page: 10 ident: bib0095 article-title: CGH and SNP array using DNA extracted from fixed cytogenetic preparations and long-term refrigerated bone marrow specimens publication-title: Mol. Cytogenet – volume: 16 start-page: 129 year: 2010 end-page: 136 ident: bib0055 article-title: Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia publication-title: Mol. Med – volume: 101 start-page: 1664 year: 2016 end-page: 1672 ident: bib0135 article-title: Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study publication-title: J. Clin. Endocrinol. Metab – volume: 33 start-page: 4 year: 2014 ident: bib0155 article-title: Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma publication-title: J. Exp. Clin. Cancer Res – volume: 32 start-page: 1031 year: 2015 ident: 10.1016/j.rbmo.2017.07.010_bib0160 article-title: Unaltered timing of embryo development in women with polycystic ovarian syndrome (PCOS): a time-lapse study publication-title: J. Assist. Reprod. Genet doi: 10.1007/s10815-015-0488-0 – volume: 7 start-page: 745 year: 2015 ident: 10.1016/j.rbmo.2017.07.010_bib0115 article-title: Complications and challenges associated with polycystic ovary syndrome: current perspectives publication-title: Int. J. Womens Health doi: 10.2147/IJWH.S70314 – volume: 11 start-page: 1376 year: 2015 ident: 10.1016/j.rbmo.2017.07.010_bib0090 article-title: Regulation of androgen receptor expression alters AMPK phosphorylation in the endometrium: in vivo and in vitro studies in women with polycystic ovary syndrome publication-title: Int. J. Biol. Sci doi: 10.7150/ijbs.13109 – volume: 18 start-page: 856 year: 2009 ident: 10.1016/j.rbmo.2017.07.010_bib0025 article-title: Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies publication-title: Reprod. Biomed. Online doi: 10.1016/S1472-6483(10)60037-5 – volume: 30 start-page: 1169 year: 2013 ident: 10.1016/j.rbmo.2017.07.010_bib0030 article-title: Fertility management in the PCOS population: results of a web-based survey at IVF-worldwide.com publication-title: J. Assist. Reprod. Genet doi: 10.1007/s10815-013-0069-z – volume: 94 start-page: 290 year: 2010 ident: 10.1016/j.rbmo.2017.07.010_bib0110 article-title: Body mass index and risk of miscarriage in women with recurrent miscarriage publication-title: Fertil. Steril doi: 10.1016/j.fertnstert.2009.03.021 – volume: 6 start-page: 79 year: 2016 ident: 10.1016/j.rbmo.2017.07.010_bib0075 article-title: Endocrine dysfunction and recurrent spontaneous abortion: an overview publication-title: Int. J. Appl. Basic Med. Res doi: 10.4103/2229-516X.179024 – volume: 89 start-page: 2745 year: 2004 ident: 10.1016/j.rbmo.2017.07.010_bib0015 article-title: The prevalence and features of the polycystic ovary syndrome in an unselected population publication-title: J. Clin. Endocrinol. Metab doi: 10.1210/jc.2003-032046 – volume: 17 start-page: 17 year: 2011 ident: 10.1016/j.rbmo.2017.07.010_bib0125 article-title: Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence publication-title: Hum. Reprod. Update doi: 10.1093/humupd/dmq032 – volume: 33 start-page: 4 year: 2014 ident: 10.1016/j.rbmo.2017.07.010_bib0155 article-title: Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma publication-title: J. Exp. Clin. Cancer Res doi: 10.1186/1756-9966-33-41 – volume: 19 start-page: 41 year: 2004 ident: 10.1016/j.rbmo.2017.07.010_bib0145 article-title: Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome (PCOS) publication-title: Hum. Reprod doi: 10.1093/humrep/deh098 – volume: 88 start-page: 900 year: 2007 ident: 10.1016/j.rbmo.2017.07.010_bib0175 article-title: Lack of association between polycystic ovary syndrome and embryonic aneuploidy publication-title: Fertil. Steril doi: 10.1016/j.fertnstert.2006.12.018 – volume: 94 start-page: 1416 year: 2000 ident: 10.1016/j.rbmo.2017.07.010_bib0080 article-title: Transcriptional profiling with a pathway-oriented analysis identifies dysregulated molecular phenotypes in the endometrium of patients with polycystic ovary syndrome publication-title: J. Clin. Endocrinol. Metab doi: 10.1210/jc.2008-1612 – volume: 2 start-page: 5 year: 2012 ident: 10.1016/j.rbmo.2017.07.010_bib0095 article-title: CGH and SNP array using DNA extracted from fixed cytogenetic preparations and long-term refrigerated bone marrow specimens publication-title: Mol. Cytogenet – volume: 8 start-page: 959 year: 1993 ident: 10.1016/j.rbmo.2017.07.010_bib0020 article-title: Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin publication-title: Hum. Reprod doi: 10.1093/oxfordjournals.humrep.a138174 – volume: 30 start-page: 1203 year: 2015 ident: 10.1016/j.rbmo.2017.07.010_bib0120 article-title: Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro publication-title: Hum. Reprod doi: 10.1093/humrep/dev055 – volume: 25 start-page: 544 year: 2010 ident: 10.1016/j.rbmo.2017.07.010_bib0100 article-title: The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria publication-title: Hum. Reprod doi: 10.1093/humrep/dep399 – volume: 375 start-page: 23 year: 2016 ident: 10.1016/j.rbmo.2017.07.010_bib0045 article-title: Fresh versus frozen embryos for infertility in the polycystic ovary syndrome publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa1513873 – year: 1999 ident: 10.1016/j.rbmo.2017.07.010_bib0060 article-title: In-vitro culture of human blastocyst – volume: 15 start-page: 612 year: 2000 ident: 10.1016/j.rbmo.2017.07.010_bib0130 article-title: Polycystic ovaries and recurrent miscarriage – a reappraisal publication-title: Hum. Reprod doi: 10.1093/humrep/15.3.612 – volume: 26 start-page: 53 year: 2008 ident: 10.1016/j.rbmo.2017.07.010_bib0050 article-title: Implications of Polycystic Ovary Syndrome (PCOS) on oocyte development publication-title: Semin. Reprod. Med doi: 10.1055/s-2007-992925 – volume: 15 start-page: 2786 year: 2008 ident: 10.1016/j.rbmo.2017.07.010_bib0035 article-title: High-throughput analysis of chromosome abnormality in spontaneous miscarriage using an MLPA subtelomere assay with ancillary FISH test for polyploidy publication-title: Am. J. Med. Genet – volume: 343 start-page: d6309 year: 2011 ident: 10.1016/j.rbmo.2017.07.010_bib0140 article-title: Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study publication-title: BMJ doi: 10.1136/bmj.d6309 – volume: 90 start-page: 714 year: 2008 ident: 10.1016/j.rbmo.2017.07.010_bib0105 article-title: Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence publication-title: Fertil. Steril doi: 10.1016/j.fertnstert.2007.07.1290 – volume: 85 start-page: 2434 year: 2000 ident: 10.1016/j.rbmo.2017.07.010_bib0010 article-title: A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain publication-title: J. Clin. Endocrinol. Metab – volume: 96 start-page: 1737 year: 2011 ident: 10.1016/j.rbmo.2017.07.010_bib0150 article-title: Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles publication-title: J. Clin. Endocrinol. Metab doi: 10.1210/jc.2010-2600 – volume: 16 start-page: 129 year: 2010 ident: 10.1016/j.rbmo.2017.07.010_bib0055 article-title: Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia publication-title: Mol. Med doi: 10.2119/molmed.2009.00118 – volume: 65 start-page: 52 year: 1996 ident: 10.1016/j.rbmo.2017.07.010_bib0065 article-title: Studies on the cytogenetic and endocrinologic background of spontaneous abortion publication-title: Fertil. Steril doi: 10.1016/S0015-0282(16)58026-1 – volume: 101 start-page: 1664 year: 2016 ident: 10.1016/j.rbmo.2017.07.010_bib0135 article-title: Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study publication-title: J. Clin. Endocrinol. Metab doi: 10.1210/jc.2015-2682 – volume: 33 start-page: 85 year: 2016 ident: 10.1016/j.rbmo.2017.07.010_bib0165 article-title: Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome publication-title: Reprod. Biomed. Online doi: 10.1016/j.rbmo.2016.04.006 – volume: 21 start-page: 2 year: 2014 ident: 10.1016/j.rbmo.2017.07.010_bib0085 article-title: Endometrial progesterone resistance and PCOS publication-title: J. Biomed. Sci doi: 10.1186/1423-0127-21-2 – volume: 22 start-page: 103 year: 2011 ident: 10.1016/j.rbmo.2017.07.010_bib0040 article-title: Metabolic syndrome and oocyte quality publication-title: Trends Endocrinol. Metab doi: 10.1016/j.tem.2010.12.002 – volume: 51 start-page: 84 year: 2008 ident: 10.1016/j.rbmo.2017.07.010_bib0170 article-title: Genetics of pregnancy loss publication-title: Clin. Obstet. Gynecol doi: 10.1097/GRF.0b013e318161719c – volume: 15 start-page: 228 year: 2015 ident: 10.1016/j.rbmo.2017.07.010_bib0070 article-title: Body mass index at age 18–20 and later risk of spontaneous abortion in the Health Examinees Study (HEXA) publication-title: BMC Pregnancy Childbirth doi: 10.1186/s12884-015-0665-2 |
| SSID | ssj0018083 |
| Score | 2.4212005 |
| Snippet | The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 576 |
| SubjectTerms | Abortion, Spontaneous Adult Body Composition Case-Control Studies early miscarriage Embryo Transfer Female Humans polycystic ovary syndrome Polycystic Ovary Syndrome - physiopathology pre-implantation genetic diagnosis Pregnancy Pregnancy Rate Retrospective Studies Vitrification vitrified-warmed embryo transfer Young Adult |
| Title | Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer – a matched-pair study |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1472648317303462 https://dx.doi.org/10.1016/j.rbmo.2017.07.010 https://www.ncbi.nlm.nih.gov/pubmed/28802704 https://www.proquest.com/docview/1928785657 |
| Volume | 35 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NatwwEBYhhdJLaZP-bJuGKZReirqWLVvycQkN25bk0gZyM_pzcdm1jbNb8KX0HfKGeZKMZHuh0KZQ8MVCg4VmNPPJmvlEyBuEQNYqmdBSi4RyYVKaa6WoJ46JMpNlJhQKn51nywv-6TK93CMnUy2MT6scff_g04O3Hlvm42zO26qaf2Fc-PQsDIDohnnww5wLb-Xvf-7SPJiMAhWn70x977FwZsjx6vTaFwAyEQg8fRXtn4PT38BnCEKnj8jDET3CYhjgY7Ln6gNyuKhx57zu4S2EfM7wo_yA3D8bj80PyTbQGAOq1KgOLe6bA88QAVUNK6dqaJtVb3rP2AzND9X1MPEYQCBogHCROLhtu2oqC26tu76BTYC82H7z6xoUIPJF_VvaqqqDQFr7hFycfvh6sqTjfQvUpExsaOJcpk2pc1viOjY2LpPElKllRkSxzlmihJCuFEal2kiey0grHce4N3cmcdImT8l-3dTuOYEoV5lEKxDOb3BsqVjuUoQypZSWq0zPCJsmujAjGbm_E2NVTFln3wuvnMIrp4jwYdGMvNvJtAMVx529k0l_xVRkim6xwEhxp1S6k_rNDP8p93oykcIr02eu1a7ZXhWIoKWQ_nB5Rp4NtrMbfYzOMxYRf_GfX31JHvi3oTTyiOxvuq17hRhpo4_DIjgm9xYfPy_PbwEzMxPh |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3di9QwEA_HHqgvond-rJ46gvgiZfud9HE57tjzbvfFO7i3kK9KZbctdVfom_-D_6F_iZk0XRD0BKFPaYaGzGTml2bmF0LeWQiktWBJUEqaBClVWVBIIQIkjglzlefKFQovV_niJv14m90ekNOxFgbTKr3vH3y689a-ZeZnc9ZW1exTlFJMz7IB0LrhFP3wIbJTZRNyOL-4XKz2hwksdGyc2D9AAV87M6R5dXKDNYARdRyeWEj75_j0N_zp4tD5I_LQA0iYD2N8TA5MfUSO57XdPG96eA8updP9Kz8i95b-5PyY7ByTMVitKtFZo_tsAEkioKphbUQNbbPuVY-kzdB8E10PI5UBOI4GcHeJg9m166bSYDay6xvYOtRr239-_wECLPi1JqCDVlQdON7aJ-Tm_Oz6dBH4KxcClUV0GyTG5FKVstClXcpKx2WSqDLTkaJhLIsoEZQyU1IlMqlYWrBQChnHdntuVGKYTp6SSd3U5jmBsBA5s4ZADe5xdCmiwmQWzZSM6VTkckqicaK58nzkeC3Gmo-JZ184Koejcnhonyickg97mXZg47izdzLqj491ptYzchss7pTK9lK_WeI_5d6OJsJRmZi8Vptm95VbEM0ow_PlKXk22M5-9LH1nzEN0xf_-dU35P7iennFry5Wly_JA3wzVEqekMm225lXFjJt5Wu_JH4BkmQWkg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Early+miscarriage+rate+in+lean+polycystic+ovary+syndrome+women+after+euploid+embryo+transfer+%E2%80%93+a+matched-pair+study&rft.jtitle=Reproductive+biomedicine+online&rft.au=Luo%2C+Lu&rft.au=Gu%2C+Fang&rft.au=Jie%2C+Huying&rft.au=Ding%2C+Chenhui&rft.date=2017-11-01&rft.pub=Elsevier+Ltd&rft.issn=1472-6483&rft.volume=35&rft.issue=5&rft.spage=576&rft.epage=582&rft_id=info:doi/10.1016%2Fj.rbmo.2017.07.010&rft.externalDocID=S1472648317303462 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1472-6483&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1472-6483&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1472-6483&client=summon |