Trigemino-autonomic activation in a human trigeminal pain model

• Published in: BMC neurology Vol. 25; no. 1; pp. 145 - 5
• Main Authors: Evers, Stefan, Frese, Achim, Hornberg, Patrick, Summ, Oliver
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.04.2025; BioMed Central; BMC
• Subjects: Adult; Autonomic Nervous System - physiopathology; Capsaicin; Care and treatment; Cluster headache; Diagnosis; Epidemiology; Female; Females; Headache; Headaches; Humans; Injection; Male; Migraine; Neuralgia, Trigeminal; Pain; Pain Measurement; Trigeminal Autonomic Cephalalgias - chemically induced; Trigeminal Autonomic Cephalalgias - diagnosis; Trigeminal Autonomic Cephalalgias - physiopathology; Trigeminal Nerve - physiopathology; Trigemino-autonomic symptoms; Young Adult; Germany; Capsaicin; Cluster headache; Trigemino-autonomic symptoms
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-025-04147-y

Autonomic symptoms are mandatory for making the diagnosis of a trigemino-autonomic cephalalgia (TAC). These symptoms can occasionally also occur in migraine and facial pain disorders. This leads to the question whether the trigeminal pain itself can induce autonomic symptoms also in healthy subjects...