A new era of long-read sequencing for cancer genomics

• Published in: Journal of human genetics Vol. 65; no. 1; pp. 3 - 10
• Main Authors: Sakamoto, Yoshitaka, Sereewattanawoot, Sarun, Suzuki, Ayako
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.01.2020; Springer Singapore
• Subjects: Cancer; Chromatin Immunoprecipitation Sequencing - methods; Chromatin Immunoprecipitation Sequencing - trends; DNA Methylation; DNA sequencing; Epigenome; Gene expression; Genomics; Genomics - methods; Genomics - trends; Haplotypes; Humans; Isoforms; Mutation; Neoplasms - genetics; Nucleotide sequence; Protein Isoforms - genetics; Review; RNA-Seq - methods; RNA-Seq - trends; Transcription; Transcriptome - genetics

Cancer is a disease largely caused by genomic aberrations. Utilizing many rapidly emerging sequencing technologies, researchers have studied cancer genomes to understand the molecular statuses of cancer cells and to reveal their vulnerabilities, such as driver mutations or gene expression. Long-read...