Generation of vascular chimerism within donor organs

• Published in: Scientific reports Vol. 11; no. 1; pp. 13437 - 15
• Main Authors: Cohen, Shahar, Partouche, Shirly, Gurevich, Michael, Tennak, Vladimir, Mezhybovsky, Vadym, Azarov, Dmitry, Soffer-Hirschberg, Sarit, Hovav, Benny, Niv-Drori, Hagit, Weiss, Chana, Borovich, Adi, Cohen, Guy, Wertheimer, Avital, Shukrun, Golan, Israeli, Moshe, Yahalom, Vered, Leshem-Lev, Dorit, Perl, Leor, Kornowski, Ran, Wiznitzer, Arnon, Tobar, Ana, Feinmesser, Meora, Mor, Eytan, Atar, Eli, Nesher, Eviatar
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/61/2035; 631/61/490; 692/308/575; Aorta; Chimerism; Coronary vessels; Endothelial cells; Heart; Humanities and Social Sciences; Immunogenicity; Immunology; Kidneys; Limbs; multidisciplinary; Organs; Pancreas; Perfusion; Placenta; Progenitor cells; Science; Science (multidisciplinary); Stem cells; Xenografts; Xenotransplantation

Whole organ perfusion decellularization has been proposed as a promising method to generate non-immunogenic organs from allogeneic and xenogeneic donors. However, the ability to recellularize organ scaffolds with multiple patient-specific cells in a spatially controlled manner remains challenging. H...