Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human

Epigenetic information regulates gene expression and development. However, our understanding of the evolution of epigenetic regulation on brain development in primates is limited. Here, we compared chromatin accessibility landscapes and transcriptomes during fetal prefrontal cortex (PFC) development...

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Published inNature communications Vol. 13; no. 1; p. 3883
Main Authors Yao, Xuelong, Lu, Zongyang, Feng, Zhanying, Gao, Lei, Zhou, Xin, Li, Min, Zhong, Suijuan, Wu, Qian, Liu, Zhenbo, Zhang, Haofeng, Liu, Zeyuan, Yi, Lizhi, Zhou, Tao, Zhao, Xudong, Zhang, Jun, Wang, Yong, Huang, Xingxu, Wang, Xiaoqun, Liu, Jiang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 06.07.2022
Nature Publishing Group
Nature Portfolio
Subjects
13/1
13/51
38/23
38/39
38/91
45/100
631/378/2571/1696
631/378/2584/1695
Accessibility
Brain
Chromatin
Cognitive ability
Comparative studies
Deoxyribonuclease
Deoxyribonucleic acid
Divergence
DNA
Epigenetics
Evolution
Fetuses
Gene expression
Gene sequencing
Genes
Human performance
Humanities and Social Sciences
Macaca mulatta
multidisciplinary
Nucleotide sequence
Prefrontal cortex
Primates
Regulatory sequences
Science
Science (multidisciplinary)
Transcriptomes
Online AccessGet full text

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Abstract Epigenetic information regulates gene expression and development. However, our understanding of the evolution of epigenetic regulation on brain development in primates is limited. Here, we compared chromatin accessibility landscapes and transcriptomes during fetal prefrontal cortex (PFC) development between rhesus macaques and humans. A total of 304,761 divergent DNase I-hypersensitive sites (DHSs) are identified between rhesus macaques and humans, although many of these sites share conserved DNA sequences. Interestingly, most of the cis -elements linked to orthologous genes with dynamic expression are divergent DHSs. Orthologous genes expressed at earlier stages tend to have conserved cis -elements, whereas orthologous genes specifically expressed at later stages seldom have conserved cis -elements. These genes are enriched in synapse organization, learning and memory. Notably, DHSs in the PFC at early stages are linked to human educational attainment and cognitive performance. Collectively, the comparison of the chromatin epigenetic landscape between rhesus macaques and humans suggests a potential role for regulatory elements in the evolution of differences in cognitive ability between non-human primates and humans. The evolution of epigenetic regulation of brain development in primates is not well understood. Here, the authors perform a comparative study of epigenetic dynamics of early prefrontal cortex development between human and rhesus macaque, finding divergent regulatory elements that may be related to cognitive capacity.
AbstractList Epigenetic information regulates gene expression and development. However, our understanding of the evolution of epigenetic regulation on brain development in primates is limited. Here, we compared chromatin accessibility landscapes and transcriptomes during fetal prefrontal cortex (PFC) development between rhesus macaques and humans. A total of 304,761 divergent DNase I-hypersensitive sites (DHSs) are identified between rhesus macaques and humans, although many of these sites share conserved DNA sequences. Interestingly, most of the cis-elements linked to orthologous genes with dynamic expression are divergent DHSs. Orthologous genes expressed at earlier stages tend to have conserved cis-elements, whereas orthologous genes specifically expressed at later stages seldom have conserved cis-elements. These genes are enriched in synapse organization, learning and memory. Notably, DHSs in the PFC at early stages are linked to human educational attainment and cognitive performance. Collectively, the comparison of the chromatin epigenetic landscape between rhesus macaques and humans suggests a potential role for regulatory elements in the evolution of differences in cognitive ability between non-human primates and humans.The evolution of epigenetic regulation of brain development in primates is not well understood. Here, the authors perform a comparative study of epigenetic dynamics of early prefrontal cortex development between human and rhesus macaque, finding divergent regulatory elements that may be related to cognitive capacity.
Epigenetic information regulates gene expression and development. However, our understanding of the evolution of epigenetic regulation on brain development in primates is limited. Here, we compared chromatin accessibility landscapes and transcriptomes during fetal prefrontal cortex (PFC) development between rhesus macaques and humans. A total of 304,761 divergent DNase I-hypersensitive sites (DHSs) are identified between rhesus macaques and humans, although many of these sites share conserved DNA sequences. Interestingly, most of the cis -elements linked to orthologous genes with dynamic expression are divergent DHSs. Orthologous genes expressed at earlier stages tend to have conserved cis -elements, whereas orthologous genes specifically expressed at later stages seldom have conserved cis -elements. These genes are enriched in synapse organization, learning and memory. Notably, DHSs in the PFC at early stages are linked to human educational attainment and cognitive performance. Collectively, the comparison of the chromatin epigenetic landscape between rhesus macaques and humans suggests a potential role for regulatory elements in the evolution of differences in cognitive ability between non-human primates and humans. The evolution of epigenetic regulation of brain development in primates is not well understood. Here, the authors perform a comparative study of epigenetic dynamics of early prefrontal cortex development between human and rhesus macaque, finding divergent regulatory elements that may be related to cognitive capacity.
The evolution of epigenetic regulation of brain development in primates is not well understood. Here, the authors perform a comparative study of epigenetic dynamics of early prefrontal cortex development between human and rhesus macaque, finding divergent regulatory elements that may be related to cognitive capacity.
Abstract Epigenetic information regulates gene expression and development. However, our understanding of the evolution of epigenetic regulation on brain development in primates is limited. Here, we compared chromatin accessibility landscapes and transcriptomes during fetal prefrontal cortex (PFC) development between rhesus macaques and humans. A total of 304,761 divergent DNase I-hypersensitive sites (DHSs) are identified between rhesus macaques and humans, although many of these sites share conserved DNA sequences. Interestingly, most of the cis -elements linked to orthologous genes with dynamic expression are divergent DHSs. Orthologous genes expressed at earlier stages tend to have conserved cis -elements, whereas orthologous genes specifically expressed at later stages seldom have conserved cis -elements. These genes are enriched in synapse organization, learning and memory. Notably, DHSs in the PFC at early stages are linked to human educational attainment and cognitive performance. Collectively, the comparison of the chromatin epigenetic landscape between rhesus macaques and humans suggests a potential role for regulatory elements in the evolution of differences in cognitive ability between non-human primates and humans.
ArticleNumber 3883
Author Liu, Zeyuan
Huang, Xingxu
Li, Min
Zhou, Tao
Yi, Lizhi
Lu, Zongyang
Zhou, Xin
Wu, Qian
Feng, Zhanying
Zhong, Suijuan
Wang, Yong
Yao, Xuelong
Gao, Lei
Liu, Zhenbo
Zhao, Xudong
Liu, Jiang
Wang, Xiaoqun
Zhang, Haofeng
Zhang, Jun
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  year: 2022
  text: 2022-07-06
  day: 06
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
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SSID ssj0000391844
Score 2.4631472
Snippet Epigenetic information regulates gene expression and development. However, our understanding of the evolution of epigenetic regulation on brain development in...
Abstract Epigenetic information regulates gene expression and development. However, our understanding of the evolution of epigenetic regulation on brain...
The evolution of epigenetic regulation of brain development in primates is not well understood. Here, the authors perform a comparative study of epigenetic...
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SubjectTerms 13/1
13/51
38/23
38/39
38/91
45/100
631/378/2571/1696
631/378/2584/1695
Accessibility
Brain
Chromatin
Cognitive ability
Comparative studies
Deoxyribonuclease
Deoxyribonucleic acid
Divergence
DNA
Epigenetics
Evolution
Fetuses
Gene expression
Gene sequencing
Genes
Human performance
Humanities and Social Sciences
Macaca mulatta
multidisciplinary
Nucleotide sequence
Prefrontal cortex
Primates
Regulatory sequences
Science
Science (multidisciplinary)
Transcriptomes
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Title Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human
URI https://link.springer.com/article/10.1038/s41467-022-31403-3
https://www.proquest.com/docview/2685222671
https://search.proquest.com/docview/2686057644
https://pubmed.ncbi.nlm.nih.gov/PMC9259620
https://doaj.org/article/ace5978364b447ad9fd5c4e517e51b91
Volume 13
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