Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19

• Published in: Scientific reports Vol. 11; no. 1; pp. 16535 - 5
• Main Authors: Kawasuji, Hitoshi, Morinaga, Yoshitomo, Tani, Hideki, Kimura, Miyuki, Yamada, Hiroshi, Yoshida, Yoshihiro, Takegoshi, Yusuke, Kaneda, Makito, Murai, Yushi, Kimoto, Kou, Ueno, Akitoshi, Miyajima, Yuki, Kawago, Koyomi, Fukui, Yasutaka, Sakamaki, Ippei, Yamamoto, Yoshihiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/2152/2153/1291; 631/326/596/4130; 692/699/255/2514; Adaptive immunity; Antibody response; Chemiluminescence; Coronaviruses; COVID-19; Humanities and Social Sciences; Infectivity; multidisciplinary; Neutralization; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2

Adaptive immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dynamics remain largely unknown. The neutralizing antibody (NAb) levels in patients with coronavirus disease 2019 (COVID-19) are helpful for understanding the pathology. Using SARS-CoV-2 pseudotyped virus, serum sample...