Physiological and molecular determinants of embryo implantation

• Published in: Molecular aspects of medicine Vol. 34; no. 5; pp. 939 - 980
• Main Authors: Zhang, Shuang, Lin, Haiyan, Kong, Shuangbo, Wang, Shumin, Wang, Hongmei, Wang, Haibin, Armant, D. Randall
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2013
• Subjects: Animals; Blastocyst - cytology; Blastocyst - metabolism; Blastocyst activation; Blastocyst attachment; Decidualization; Embryo implantation; Embryo Implantation - genetics; Female; Gene Expression Regulation, Developmental; Humans; Mice; Pregnancy; Signal Transduction - genetics; Uterine receptivity; Uterus - cytology; Uterus - metabolism; Embryo implantation; Blastocyst attachment; Uterine receptivity; Decidualization; Blastocyst activation

Embryo implantation involves the intimate interaction between an implantation-competent blastocyst and a receptive uterus, which occurs in a limited time period known as the window of implantation. Emerging evidence shows that defects originating during embryo implantation induce ripple effects with...