Association of serum lactate dehydrogenase levels with non-alcoholic fatty liver disease and advanced hepatic fibrosis in the United States: a cross-sectional study using NHANES data from 2007 to 2018

• Published in: BMC gastroenterology Vol. 25; no. 1; pp. 467 - 15
• Main Authors: Zhang, Xiaotong, Liu, Min, Huang, Junjun, Zheng, Ya, Wang, Yuping, Zhou, Yongning
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.07.2025; BioMed Central; BMC
• Subjects: Adult; Alcohol; Analysis; Biomarker; Biomarkers; Biopsy; Body mass index; Care and treatment; Complications and side effects; Cross-sectional analysis; Cross-Sectional Studies; Dehydrogenases; Diabetes; Diagnosis; Diseases; Enzymes; Fatty liver; Female; Fibrosis; Health aspects; Hepatitis; Humans; Hypertension; Information management; L-Lactate dehydrogenase; L-Lactate Dehydrogenase - blood; Lactate dehydrogenase; Liver cancer; Liver cirrhosis; Liver Cirrhosis - blood; Liver Cirrhosis - epidemiology; Liver diseases; Male; Marital status; Measurement; Metabolism; Middle Aged; NAFLD; NHANES; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - epidemiology; Nutrition; Nutrition Surveys; Population studies; Prevalence; Reagents; Risk factors; Secondary schools; Steatosis; Time trends (Statistics); United States; United States - epidemiology; Weight control; United States; United States > US; Lactate dehydrogenase; Biomarker; NAFLD; NHANES; Cross-sectional analysis

The associations between LDH and non-alcoholic fatty liver disease (NAFLD), as well as advanced hepatic fibrosis (AHF), have not been explored. This study aims to investigate the association between log-transformed LDH levels and the prevalence of NAFLD and AHF. In this cross-sectional study, after...