Tuberculosis Diagnosis by Metagenomic Next-generation Sequencing on Bronchoalveolar Lavage Fluid: a cross-sectional analysis

• Published in: International journal of infectious diseases Vol. 104; pp. 50 - 57
• Main Authors: Liu, Xi, Chen, Yuanli, Ouyang, Hui, Liu, Jian, Luo, Xiaoqing, Huang, Yayi, Chen, Yan, Ma, Jinmin, Xia, Jinyu, Ding, Li
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.03.2021; Elsevier
• Subjects: Adult; Bronchoalveolar lavage fluid; Bronchoalveolar Lavage Fluid - microbiology; Cross-Sectional Studies; Diagnostic performance; Female; High-Throughput Nucleotide Sequencing; Humans; Male; Metagenomic Next-generation Sequencing; Metagenomics; Middle Aged; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - isolation & purification; Tuberculosis; Tuberculosis, Pulmonary - diagnosis; Diagnostic performance; Bronchoalveolar lavage fluid; Tuberculosis; Metagenomic Next-generation Sequencing

•Metagenomic next-generation sequencing (mNGS) improves sensitivity of Mycobacterium tuberculosis complex (MTBC) detection in bronchoalveolar lavage fluid (BALF).•MTBC detection by mNGS was affected by Vitamin D, erythrocyte sedimentation rate, TB retreatment and cavity in chest.•MTBC detection by m...