Time-dependent involvement of the dorsal hippocampus in trace fear conditioning in mice

• Published in: Hippocampus Vol. 15; no. 4; pp. 418 - 426
• Main Authors: Misane, Ilga, Tovote, Philip, Meyer, Michael, Spiess, Joachim, Ögren, Sven Ove, Stiedl, Oliver
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 2005
• Subjects: 2-Amino-5-phosphonovalerate - pharmacology; Acoustic Stimulation; Amygdala - drug effects; Amygdala - physiology; Animals; conditioned stimulus; Conditioning (Psychology) - drug effects; Conditioning (Psychology) - physiology; Cues; Excitatory Amino Acid Antagonists - pharmacology; Fear - drug effects; Fear - physiology; freezing; Glutamic Acid - metabolism; Hippocampus - drug effects; Hippocampus - physiology; Learning - drug effects; Learning - physiology; learning and memory; Male; Medicin och hälsovetenskap; Memory - drug effects; Memory - physiology; Mice; Mice, Inbred C57BL; Neural Pathways - drug effects; Neural Pathways - physiology; Neuronal Plasticity - drug effects; Neuronal Plasticity - physiology; NMDA receptors; Receptors, N-Methyl-D-Aspartate - drug effects; Receptors, N-Methyl-D-Aspartate - metabolism; Synaptic Transmission - drug effects; Synaptic Transmission - physiology; Time Factors; unconditioned stimulus

Hippocampal and amygdaloid neuroplasticity are important substrates for Pavlovian fear conditioning. The hippocampus has been implicated in trace fear conditioning. However, a systematic investigation of the significance of the trace interval has not yet been performed. Therefore, this study analyze...