Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity

• Published in: The journal of clinical endocrinology and metabolism Vol. 101; no. 5; pp. 1935 - 1944
• Main Authors: Haeusler, Rebecca A., Camastra, Stefania, Nannipieri, Monica, Astiarraga, Brenno, Castro-Perez, Jose, Xie, Dan, Wang, Liangsu, Chakravarthy, Manu, Ferrannini, Ele
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2016; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adult; Bile; Bile Acids and Salts - biosynthesis; Bile Acids and Salts - metabolism; Biological Transport; Body mass index; Carrier Proteins - metabolism; Duodenum; Female; Glucose Clamp Technique; Humans; Hydroxylation; Ileum; Insulin; Intestines - metabolism; Jejunum; Liver; Liver - metabolism; Male; Membrane Glycoproteins - metabolism; Metabolic disorders; Metabolic pathways; Metabolism; Obesity; Obesity - metabolism; Original; Pancreas - metabolism; Pathophysiology; Therapeutic targets

Context:Alterations in bile acid (BA) synthesis and transport have the potential to affect multiple metabolic pathways in the pathophysiology of obesity.Objective:The objective of the study was to investigate the effects of obesity on serum fluctuations of BAs and markers of BA synthesis.Design:We m...