Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials

• Published in: Annals of the New York Academy of Sciences Vol. 1207; no. 1; pp. 155 - 162
• Main Author: Gorelick, Philip B.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.10.2010; Wiley Subscription Services, Inc
• Subjects: Aged; Alzheimer's disease; Anti-inflammatory agents; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Biomarkers - analysis; Clinical trials; Clinical Trials as Topic; Cognition Disorders - etiology; Cognition Disorders - prevention & control; Cognition Disorders - therapy; Cognitive ability; cognitive impairment; Dementia; Dementia - etiology; Dementia - prevention & control; Dementia - therapy; Dementia disorders; Epidemiologic Studies; Humans; Immunotherapy; inflammation; Inflammation - complications; Inflammation - drug therapy; Inflammation Mediators - analysis; Metabolic Syndrome - complications; Nonsteroidal anti-inflammatory drugs; nonsteroidal antiinflammatory drugs; Observational studies; Prevention; stroke; vascular cognitive impairment

Inflammation may be an important mechanism underlying dementia and cognitive decline in the elderly. Inflammation has been implicated in the neuropathological cascade leading to the development of Alzheimer's disease and other common forms of dementia in later life. These observations have led...