Hemodynamic effects of clonidine in two contrasting models of autonomic failure: Multiple system atrophy and pure autonomic failure

• Published in: Movement Disorders Vol. 21; no. 5; pp. 609 - 615
• Main Authors: Young, Tim M., Asahina, Masato, Watson, Laura, Mathias, Christopher J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2006; Wiley
• Subjects: Adrenergic alpha-Agonists; Adrenergic alpha-Agonists - administration & dosage; Autonomic Nervous System Diseases; Autonomic Nervous System Diseases - blood; Autonomic Nervous System Diseases - drug therapy; Autonomic Nervous System Diseases - physiopathology; Biological and medical sciences; Blood Pressure; Blood Pressure - drug effects; Case-Control Studies; Clonidine; Clonidine - administration & dosage; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Heart Rate; Heart Rate - drug effects; Hemodynamics; Hemodynamics - drug effects; Humans; Medical sciences; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple System Atrophy; Multiple System Atrophy - blood; Multiple System Atrophy - drug therapy; Multiple System Atrophy - physiopathology; Neurology; Norepinephrine; Norepinephrine - blood; pure autonomic failure; Retrospective Studies; Statistics, Nonparametric; Time Factors; pure autonomic failure; Nervous system diseases; Diseases of the autonomic nervous system; Multiple system atrophy; Arterial pressure; Clonidine; Models; Blood pressure; Hemodynamics
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.20755

We assessed the effects of clonidine on blood pressure (BP) and heart rate (HR) in multiple system atrophy (MSA), where the autonomic nervous system lesion site is preganglionic, and in pure autonomic failure (PAF), where it is postganglionic. In normal subjects, intravenous infusion of the selectiv...