Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 101; no. 4; pp. 1422 - 1428
• Main Authors: Lawler, Helen M., Underkofler, Chantal M., Kern, Philip A., Erickson, Christopher, Bredbeck, Brooke, Rasouli, Neda
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2016; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adiponectin; Adipose tissue; Adipose Tissue - pathology; Adult; Body fat; Body mass index; Cohort Studies; Extracellular matrix; Female; Fibrosis; Fibrosis - etiology; Fibrosis - pathology; Gene expression; Humans; Hypoglycemic Agents - pharmacology; Hypoxia; Hypoxia - etiology; Hypoxia - pathology; Inflammation; Inflammation - etiology; Inflammation - pathology; Insulin - pharmacology; Insulin Resistance; Leptin; Lipogenesis; Low density lipoprotein; Low density lipoprotein receptors; Male; Matrilysin; Middle Aged; Obesity; Obesity - complications; Obesity - drug therapy; Original; Oxygenation; Pathogenesis; Scavenger receptors; Vascular endothelial growth factor; Young Adult

Context:A substantial number of obese individuals are relatively insulin sensitive and the etiology for this variation remains unknown.Objective:The primary objective was to detect factors in adipose tissue differentiating obese insulin-sensitive (OBIS) from obese insulin-resistant (OBIR) individual...