The Impact of Depot GnRH Agonist on AMH Levels in Healthy Reproductive-Aged Women

• Published in: The journal of clinical endocrinology and metabolism Vol. 98; no. 12; pp. E1961 - E1966
• Main Authors: Su, H. Irene, Maas, Kevin, Sluss, Patrick M., Chang, R. Jeffrey, Hall, Janet E., Joffe, Hadine
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.12.2013; Copyright by The Endocrine Society; Endocrine Society
• Subjects: 17β-Estradiol; Adolescent; Adult; Agonists; Anti-Mullerian Hormone - blood; Anti-Mullerian Hormone - secretion; Biomarkers - blood; Chemotherapy; Cohort Studies; Delayed-Action Preparations; Female; Fertility; Fertility Agents, Female - administration & dosage; Fertility Agents, Female - pharmacology; Fertility Preservation; Follicle-stimulating hormone; Gonadotropin-releasing hormone; Gonadotropin-Releasing Hormone - agonists; Gonadotropins; Granulosa cells; Granulosa Cells - drug effects; Granulosa Cells - secretion; Humans; JCEM Online: Brief Reports; Leuprolide - administration & dosage; Leuprolide - pharmacology; Luteinizing hormone; Menstrual Cycle - blood; Menstrual Cycle - drug effects; Middle Aged; Ovaries; Ovary - drug effects; Ovary - secretion; Pituitary (anterior); Progesterone; Young Adult

Context:GnRH agonists (GnRHa) are being used experimentally in an attempt to preserve fertility in young female cancer patients undergoing chemotherapy. Anti-Müllerian hormone (AMH) produced by ovarian granulosa cells may serve as a marker of ovarian reserve, but it is not clear whether this marker...