De Novo Sirolimus and Reduced‐Dose Tacrolimus Versus Standard‐Dose Tacrolimus After Liver Transplantation: The 2000–2003 Phase II Prospective Randomized Trial - Asrani, S. K.; Wiesner, R. H.; Trotter, J. F.; Klintmalm, G.; Katz, E.; Maller, E.; Roberts, J.; Kneteman, N.; Teperman, L.; Fung, J. J.; Millis, J. M. (American journal of transplantation, 2014)
Keywords: Adult; Biological and medical sciences; Black box; Blood and lymphatic vessels; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dose-Response Relationship, Drug; Drug therapy; Female; Follow-Up Studies; graft failure; Graft Rejection - drug therapy; Graft Rejection - etiology; Graft Rejection - mortality; Graft Survival - drug effects; hepatic artery thrombosis; Humans; Immunosuppressive Agents - therapeutic use; International Agencies; Liver; Liver Diseases - complications; Liver Diseases - mortality; Liver Diseases - surgery; Liver Transplantation; Liver, biliary tract, pancreas, portal circulation, spleen; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; patient death; portal vein thrombosis; Prognosis; Prospective Studies; rapamycin; Renal failure; Sirolimus - therapeutic use; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Survival Rate; Tacrolimus - therapeutic use; Thrombosis; Time Factors; Transplantation Immunology; Transplants & implants; Antineoplastic agent; Warning; Calcineurin inhibitor; Sirolimus; Liver; Cardiovascular disease; Black box; Homotransplantation; Posology; Macrocycle; Venous disease; Arterial disease; Vascular disease; Prospective; Randomization; Surgery; 2003; Phase II trial; Graft; Protein synthesis inhibitor; patient death; Kidney disease; Hepatic artery; Human; Urinary system disease; Digestive system; Low dose; Lactone; 2000; Patient; Macrolide; De novo; Standards; Graft failure; Immunomodulator; Antibiotic; Treatment; hepatic artery thrombosis; Tacrolimus; portal vein thrombosis; renal failure; Immunosuppressive agent; Artery thrombosis; Antibacterial agent; Comparative study; Liver transplantation; rapamycin; graft failure