Identification of beta-tubulin isoform V as an autoantigen in allergic rhinitis by a proteomic approach

• Published in: Microbiology and immunology Vol. 48; no. 5; p. 427
• Main Authors: Nakamura, Manabu, Tsutsumi, Kouichiro, Ooka, Seido, Sekine, Taichi, Koizuka, Izumi, Nishioka, Kusuki, Kato, Tomohiro
• Format: Journal Article
• Language: English
• Published: Australia 01.01.2004
• Subjects: Adult; Autoantibodies - blood; Autoantibodies - immunology; Autoantigens - immunology; Autoantigens - isolation & purification; Child; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Immunoblotting; Immunoglobulin E - immunology; Leukocytes, Mononuclear - chemistry; Male; Mass Spectrometry; Middle Aged; Protein Isoforms - immunology; Protein Isoforms - isolation & purification; Proteins - immunology; Proteins - isolation & purification; Proteomics; Receptors, Adrenergic, beta-2 - immunology; Rhinitis, Allergic, Perennial - immunology; Tubulin - immunology; Tubulin - isolation & purification

Autoantibodies to IgE and beta2-adrenergic receptor have been reported in patients with allergic rhinitis. To investigate whether autoimmunity in allergic rhinitis is directed to such limited molecules or directed to a wide range of self proteins, we here attempted to survey autoantigens/autoantibod...