Peptide-loaded dendritic-cell vaccination followed by treatment interruption for chronic HIV-1 infection: A phase 1 trial

• Published in: Journal of Medical Virology Vol. 78; no. 6; pp. 711 - 718
• Main Authors: Ide, Fuyuaki, Nakamura, Tetsuya, Tomizawa, Mariko, Kawana-Tachikawa, Ai, Odawara, Takashi, Hosoya, Noriaki, Iwamoto, Aikichi
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2006; Wiley; Wiley-Liss
• Subjects: Adult; Antiretroviral Therapy, Highly Active; Biological and medical sciences; CD4 Lymphocyte Count; Chronic Disease; Chronic Disease - therapy; Dendritic Cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dendritic Cells - transplantation; Drug Resistance, Viral; Drug Resistance, Viral - genetics; Epitopes, T-Lymphocyte; Epitopes, T-Lymphocyte - immunology; Fundamental and applied biological sciences. Psychology; HAART; HIV Antigens; HIV Antigens - administration & dosage; HIV Antigens - immunology; HIV Infections; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - therapy; HIV-1; HIV-1 - drug effects; HIV-1 - genetics; HIV-1 - immunology; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunotherapy; Immunotherapy - methods; Infectious diseases; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Mutation; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Cytotoxic - immunology; treatment interruption; vaccine; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Virology; HIV-1; Immunopathology; Dendritic cell; Peptides; HIV-1 virus; Vaccination; Retroviridae; AIDS; Vaccine; Immune deficiency; Lentivirus; Infection; Virus; treatment interruption; Chronic; Treatment; Viral disease; Antiviral; Human immunodeficiency virus; HAART

Immune response enhanced by therapeutic HIV‐1 vaccine may control viral proliferation after discontinuation of highly active antiretroviral therapy (HAART). Although which strategies for therapeutic vaccination are feasible remains controversial, application of dendritic cells (DCs) as a vaccine adj...