Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage

• Published in: The American journal of pathology Vol. 192; no. 9; pp. 1282 - 1294
• Main Authors: Laurence, Jeffrey, Nuovo, Gerard, Racine-Brzostek, Sabrina E., Seshadri, Madhav, Elhadad, Sonia, Crowson, A. Neil, Mulvey, J. Justin, Harp, Joanna, Ahamed, Jasimuddin, Magro, Cynthia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2022; American Society for Investigative Pathology
• Subjects: Acute Kidney Injury; Antiviral Agents; Biopsy; Complement Membrane Attack Complex; COVID-19; Humans; Interferon Type I; Mannose-Binding Protein-Associated Serine Proteases; Regular; Respiratory Distress Syndrome; Spike Glycoprotein, Coronavirus; Thrombosis

Apart from autopsy, tissue correlates of coronavirus disease 2019 (COVID-19) clinical stage are lacking. In the current study, cutaneous punch biopsy specimens of 15 individuals with severe/critical COVID-19 and six with mild/moderate COVID-19 were examined. Evidence for arterial and venous microthr...