Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 150; no. 7; pp. 1646 - 1658.e17
• Main Authors: Zhou, Shao-Lai, Zhou, Zheng-Jun, Hu, Zhi-Qiang, Huang, Xiao-Wu, Wang, Zheng, Chen, Er-Bao, Fan, Jia, Cao, Ya, Dai, Zhi, Zhou, Jian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2016
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - immunology; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Disease Progression; Drug Resistance, Neoplasm - immunology; Gastroenterology and Hepatology; Humans; Immune Response; Liver Cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Macrophages - immunology; Mice; Mouse Model; Neovascularization; Neutrophil Infiltration; Neutrophils - immunology; Niacinamide - administration & dosage; Niacinamide - analogs & derivatives; Niacinamide - immunology; Phenylurea Compounds - administration & dosage; Phenylurea Compounds - immunology; Sorafenib; T-Lymphocytes, Regulatory - immunology; TAN; Immune Response; Treg; HCC; Liver Cancer; mRNA; MAPK; HIF1; CCR; PI3K; shRNA; pPBN; MVD; Neovascularization; nPBN; PBN; PCR; Mouse Model; peripheral blood neutrophil from hepatocellular carcinoma patients; normal peripheral blood neutrophil; mitogen-activated protein kinase; messenger RNA; microvascular density; short hairpin RNA; hypoxia-inducible factor 1; peripheral blood neutrophil; hepatocellular carcinoma; polymerase chain reaction; tumor-associated neutrophil; T-regulatory; C-C chemokine receptor; phosphoinositide 3 kinase

Neutrophils can either promote or inhibit tumor progression, depending on the tumor microenvironment, via release of cytokines. Neither the factors produced by tumor-associated neutrophils (TANs) nor their effects on tumor progression have been characterized. We investigated the roles of TANs in pro...