Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 8; p. 992
• Main Authors: Mori, Matteo, Stelitano, Giovanni, Griego, Anna, Chiarelli, Laurent R, Cazzaniga, Giulia, Gelain, Arianna, Pini, Elena, Camera, Marina, Canzano, Paola, Fumagalli, Andrea, Scarpa, Edoardo, Cordiglieri, Chiara, Rizzello, Loris, Villa, Stefania, Meneghetti, Fiorella
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2022; MDPI
• Subjects: Antitubercular agents; Candidates; Chemical properties; drug development; Drug resistance; Drug therapy; Enzymes; furan; Infections; Iron; Mutation; Mycobacterial infections; mycobactins; Pathogens; Permeability; Salicylates; siderophores; Testing; Tuberculosis; Virulence; Italy

Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of M. tuberculosis (Mtb) have developed resistance against most of the established anti-TB drugs, new therapeutic options are urgently needed...