Caffeic and Chlorogenic Acids Synergistically Activate Browning Program in Human Adipocytes: Implications of AMPK- and PPAR-Mediated Pathways

• Published in: International journal of molecular sciences Vol. 21; no. 24; p. 9740
• Main Authors: Vasileva, Liliya V, Savova, Martina S, Amirova, Kristiana M, Balcheva-Sivenova, Zhivka, Ferrante, Claudio, Orlando, Giustino, Wabitsch, Martin, Georgiev, Milen I
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 21.12.2020; MDPI AG
• Subjects: adipocytes; Adipocytes, Brown - cytology; Adipocytes, Brown - drug effects; Adipocytes, Brown - metabolism; Adipogenesis; AMP-Activated Protein Kinases - metabolism; anti-obesity effect; browning; caffeic acid; chlorogenic acid; Chlorogenic Acid - pharmacology; Coffea - chemistry; Gene Expression Regulation - drug effects; Humans; Lipolysis; obesity; PPAR gamma - metabolism; Signal Transduction; anti-obesity effect; molecular docking; chlorogenic acid; browning; caffeic acid; adipocytes; obesity

Caffeic acid (CA) and chlorogenic acid (CGA) are phenolic compounds claimed to be responsible for the metabolic effects of coffee and tea consumption. Along with their structural similarities, they share common mechanisms such as activation of the AMP-activated protein kinase (AMPK) signaling. The p...