Difference in Performance of Fecal Immunochemical Tests With the Same Hemoglobin Cutoff Concentration in a Nationwide Colorectal Cancer Screening Program

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 147; no. 6; pp. 1317 - 1326
• Main Authors: Chiang, Tsung-Hsien, Chuang, Shu-Lin, Chen, Sam Li-Sheng, Chiu, Han-Mo, Yen, Amy Ming-Fang, Chiu, Sherry Yueh-Hsia, Fann, Jean Ching-Yuan, Chou, Chu-Kuang, Lee, Yi-Chia, Wu, Ming-Shiang, Chen, Hsiu-Hsi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2014
• Subjects: Adenoma - diagnosis; Adenoma - epidemiology; Aged; Colorectal Cancer; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - mortality; Feces - chemistry; Female; Gastroenterology and Hepatology; Hemoglobins - analysis; Humans; Immunochemistry - methods; Immunochemistry - statistics & numerical data; Incidence; Interval Cancer; Japan - epidemiology; Male; Mass Screening - methods; Mass Screening - statistics & numerical data; Middle Aged; Models, Biological; Occult Blood; Population Screening; Predictive Value of Tests; Referral and Consultation - statistics & numerical data; Risk Factors; Screening Test Sensitivity; Sensitivity and Specificity; Japan; Population Screening; FIT; RR; Screening Test Sensitivity; Interval Cancer; ISO; CRC; CI; Colorectal Cancer; SR; International Organization for Standardization; screening rate; fecal immunochemical test; relative risk; confidence interval
• ISSN: 0016-5085; 1528-0012; 1528-0012
• DOI: 10.1053/j.gastro.2014.08.043

We investigated whether 2 quantitative fecal immunochemical tests (FITs) with the same cutoff concentration of fecal hemoglobin perform equivalently in identifying patients with colorectal cancer (CRC). A total of 956,005 Taiwanese subjects, 50 to 69 years old, participated in a nationwide CRC scree...