Antioxidant and Proliferative Activities of Bupleuri Radix Extract Against Serum Deprivation in SH-SY5Y Cells
Bupleuri Radix (BR) is a major component of several Oriental herbal medicines used to treat stress and mental illness. There are evidences that antidepressant drugs modulate oxidative damage implicated in the pathophysiology of neuropsychiatric disorder, including depression. The aim of the present...
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| Published in | Psychiatry investigation Vol. 10; no. 1; pp. 81 - 88 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Neuropsychiatric Association
01.03.2013
대한신경정신의학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1738-3684 1976-3026 |
| DOI | 10.4306/pi.2013.10.1.81 |
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| Abstract | Bupleuri Radix (BR) is a major component of several Oriental herbal medicines used to treat stress and mental illness. There are evidences that antidepressant drugs modulate oxidative damage implicated in the pathophysiology of neuropsychiatric disorder, including depression. The aim of the present study was to investigate antioxidant and proliferative effects of BR against oxidative stress induced by serum deprivation in SH-SY5Y cells.
We examined the antioxidant effects of BR on a number of measures, including cell viability, formation of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and levels of both Bcl-2 and Bax. We also investigated the effects of BR on cell proliferation using the bromodeoxyuridine (BrdU) assay, and used Western blot analysis to measure changes in expression of the cell cycle phase regulators.
1) Serum deprivation significantly induced the loss of cell viability, the formation of ROS, the reduction of SOD activity, down-regulation of Bcl-2 expression and up-regulation of Bax expression. However, BR extract reversed these effects in dose-dependent manner. 2) Serum deprivation significantly reduced cell proliferation. Western blot analysis revealed that serum deprivation significantly decreased cyclinD1 and phosphorylated retinoblastoma (pRb) expression, and increased p27 expression. On the other hand, BR dose dependently reversed these effects.
This study suggests that aqueous extract of BR may exert potent antioxidant effects and also play an important role in regulating cell cycle progression during neurogenesis. These effects of BR may be a potentially important mechanism of antidepressant underlying the observed antioxidant and proliferative effects. |
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| AbstractList | Bupleuri Radix (BR) is a major component of several Oriental herbal medicines used to treat stress and mental illness. There are evidences that antidepressant drugs modulate oxidative damage implicated in the pathophysiology of neuropsychiatric disorder, including depression. The aim of the present study was to investigate antioxidant and proliferative effects of BR against oxidative stress induced by serum deprivation in SH-SY5Y cells.
We examined the antioxidant effects of BR on a number of measures, including cell viability, formation of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and levels of both Bcl-2 and Bax. We also investigated the effects of BR on cell proliferation using the bromodeoxyuridine (BrdU) assay, and used Western blot analysis to measure changes in expression of the cell cycle phase regulators.
1) Serum deprivation significantly induced the loss of cell viability, the formation of ROS, the reduction of SOD activity, down-regulation of Bcl-2 expression and up-regulation of Bax expression. However, BR extract reversed these effects in dose-dependent manner. 2) Serum deprivation significantly reduced cell proliferation. Western blot analysis revealed that serum deprivation significantly decreased cyclinD1 and phosphorylated retinoblastoma (pRb) expression, and increased p27 expression. On the other hand, BR dose dependently reversed these effects.
This study suggests that aqueous extract of BR may exert potent antioxidant effects and also play an important role in regulating cell cycle progression during neurogenesis. These effects of BR may be a potentially important mechanism of antidepressant underlying the observed antioxidant and proliferative effects. Objective Bupleuri Radix (BR) is a major component of several Oriental herbal medicines used to treat stress and mental illness. There are evidences that antidepressant drugs modulate oxidative damage implicated in the pathophysiology of neuropsychiatric disorder, including depression. The aim of the present study was to investigate antioxidant and proliferative effects of BR against oxidative stress induced by serum deprivation in SH-SY5Y cells. Methods We examined the antioxidant effects of BR on a number of measures, including cell viability, formation of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and levels of both Bcl-2 and Bax. We also investigated the effects of BR on cell proliferation using the bromodeoxyuridine (BrdU) assay, and used Western blot analysis to measure changes in expression of the cell cycle phase regulators. Results 1) Serum deprivation significantly induced the loss of cell viability, the formation of ROS, the reduction of SOD activity, down-regulation of Bcl-2 expression and up-regulation of Bax expression. However, BR extract reversed these effects in dose-dependent manner. 2) Serum deprivation significantly reduced cell proliferation. Western blot analysis revealed that serum deprivation significantly decreased cyclinD1 and phosphorylated retinoblastoma (pRb) expression, and increased p27 expression. On the other hand, BR dose dependently reversed these effects. Conclusion This study suggests that aqueous extract of BR may exert potent antioxidant effects and also play an important role in regulating cell cycle progression during neurogenesis. These effects of BR may be a potentially important mechanism of antidepressant underlying the observed antioxidant and proliferative effects. KCI Citation Count: 1 Bupleuri Radix (BR) is a major component of several Oriental herbal medicines used to treat stress and mental illness. There are evidences that antidepressant drugs modulate oxidative damage implicated in the pathophysiology of neuropsychiatric disorder, including depression. The aim of the present study was to investigate antioxidant and proliferative effects of BR against oxidative stress induced by serum deprivation in SH-SY5Y cells.OBJECTIVEBupleuri Radix (BR) is a major component of several Oriental herbal medicines used to treat stress and mental illness. There are evidences that antidepressant drugs modulate oxidative damage implicated in the pathophysiology of neuropsychiatric disorder, including depression. The aim of the present study was to investigate antioxidant and proliferative effects of BR against oxidative stress induced by serum deprivation in SH-SY5Y cells.We examined the antioxidant effects of BR on a number of measures, including cell viability, formation of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and levels of both Bcl-2 and Bax. We also investigated the effects of BR on cell proliferation using the bromodeoxyuridine (BrdU) assay, and used Western blot analysis to measure changes in expression of the cell cycle phase regulators.METHODSWe examined the antioxidant effects of BR on a number of measures, including cell viability, formation of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and levels of both Bcl-2 and Bax. We also investigated the effects of BR on cell proliferation using the bromodeoxyuridine (BrdU) assay, and used Western blot analysis to measure changes in expression of the cell cycle phase regulators.1) Serum deprivation significantly induced the loss of cell viability, the formation of ROS, the reduction of SOD activity, down-regulation of Bcl-2 expression and up-regulation of Bax expression. However, BR extract reversed these effects in dose-dependent manner. 2) Serum deprivation significantly reduced cell proliferation. Western blot analysis revealed that serum deprivation significantly decreased cyclinD1 and phosphorylated retinoblastoma (pRb) expression, and increased p27 expression. On the other hand, BR dose dependently reversed these effects.RESULTS1) Serum deprivation significantly induced the loss of cell viability, the formation of ROS, the reduction of SOD activity, down-regulation of Bcl-2 expression and up-regulation of Bax expression. However, BR extract reversed these effects in dose-dependent manner. 2) Serum deprivation significantly reduced cell proliferation. Western blot analysis revealed that serum deprivation significantly decreased cyclinD1 and phosphorylated retinoblastoma (pRb) expression, and increased p27 expression. On the other hand, BR dose dependently reversed these effects.This study suggests that aqueous extract of BR may exert potent antioxidant effects and also play an important role in regulating cell cycle progression during neurogenesis. These effects of BR may be a potentially important mechanism of antidepressant underlying the observed antioxidant and proliferative effects.CONCLUSIONThis study suggests that aqueous extract of BR may exert potent antioxidant effects and also play an important role in regulating cell cycle progression during neurogenesis. These effects of BR may be a potentially important mechanism of antidepressant underlying the observed antioxidant and proliferative effects. |
| Author | Park, Yong Ki Lee, Chan Hong Koo, Kyung Ah Lee, Bong Ju Cho, Hye Yeon Kim, Young Hoon Seo, Mi Kyoung Lee, Jung Goo Park, Sung Woo |
| AuthorAffiliation | 3 Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea 2 Department of Psychiatry, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea 1 Department of Psychiatry, Inje University School of Medicine, Busan, Republic of Korea 4 Department of Biological Science, University of the Science in Philadelphia, Philadelphia, PA, USA 5 College of Oriental Medicine, Dongguk University, Gyeongju, Republic of Korea |
| AuthorAffiliation_xml | – name: 2 Department of Psychiatry, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea – name: 3 Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea – name: 4 Department of Biological Science, University of the Science in Philadelphia, Philadelphia, PA, USA – name: 5 College of Oriental Medicine, Dongguk University, Gyeongju, Republic of Korea – name: 1 Department of Psychiatry, Inje University School of Medicine, Busan, Republic of Korea |
| Author_xml | – sequence: 1 givenname: Mi Kyoung surname: Seo fullname: Seo, Mi Kyoung organization: Department of Psychiatry, Inje University School of Medicine, Busan, Republic of Korea., Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea – sequence: 2 givenname: Hye Yeon surname: Cho fullname: Cho, Hye Yeon organization: Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea – sequence: 3 givenname: Chan Hong surname: Lee fullname: Lee, Chan Hong organization: Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea – sequence: 4 givenname: Kyung Ah surname: Koo fullname: Koo, Kyung Ah organization: Department of Biological Science, University of the Science in Philadelphia, Philadelphia, PA, USA – sequence: 5 givenname: Yong Ki surname: Park fullname: Park, Yong Ki organization: College of Oriental Medicine, Dongguk University, Gyeongju, Republic of Korea – sequence: 6 givenname: Jung Goo surname: Lee fullname: Lee, Jung Goo organization: Department of Psychiatry, Inje University School of Medicine, Busan, Republic of Korea., Department of Psychiatry, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea., Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea – sequence: 7 givenname: Bong Ju surname: Lee fullname: Lee, Bong Ju organization: Department of Psychiatry, Inje University School of Medicine, Busan, Republic of Korea., Department of Psychiatry, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea – sequence: 8 givenname: Sung Woo surname: Park fullname: Park, Sung Woo organization: Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea – sequence: 9 givenname: Young Hoon surname: Kim fullname: Kim, Young Hoon organization: Department of Psychiatry, Inje University School of Medicine, Busan, Republic of Korea., Department of Psychiatry, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea., Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea |
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| Keywords | Antidepressant Antioxidant effect Proliferative effect Bupleuri Radix |
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| Snippet | Bupleuri Radix (BR) is a major component of several Oriental herbal medicines used to treat stress and mental illness. There are evidences that antidepressant... Objective Bupleuri Radix (BR) is a major component of several Oriental herbal medicines used to treat stress and mental illness. There are evidences that... |
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| SubjectTerms | Original 정신과학 |
| Title | Antioxidant and Proliferative Activities of Bupleuri Radix Extract Against Serum Deprivation in SH-SY5Y Cells |
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