Kinetic Modeling without Accounting for the Vascular Component Impairs the Quantification of [11C]PBR28 Brain PET Data - Rizzo, Gaia; Veronese, Mattia; Tonietto, Matteo; Zanotti-Fregonara, Paolo; Turkheimer, Federico E; Bertoldo, Alessandra (Journal of cerebral blood flow and metabolism, 2014)
Keywords: Acetamides - pharmacokinetics; Acetamides - pharmacology; Carbon Isotopes - pharmacokinetics; Carbon Isotopes - pharmacology; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Humans; Kinetics; Models, Cardiovascular; Nerve Tissue Proteins - biosynthesis; Original; Positron-Emission Tomography; Pyridines - pharmacokinetics; Pyridines - pharmacology; Receptors, GABA - biosynthesis; RNA, Messenger - biosynthesis; [1C]PBR28; TSPO; neuroinflammation; PK11195; microglia; kinetic modeling