Molecular Mechanisms of Lysosome and Nucleus Communication

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 45; no. 11; pp. 978 - 991
• Main Authors: Zhao, Qian, Gao, Shihong Max, Wang, Meng C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2020
• Subjects: biogenesis; lysosomal adaptation; lysosomal metabolites; lysosome positioning; lysosome-to-nucleus signaling; lysosomes; metabolic diseases; neurodegenerative diseases; signal transduction; transcription (genetics); transcription factors; lysosome positioning; lysosomal metabolites; transcription factors; lysosome-to-nucleus signaling; lysosomal adaptation

Lysosomes transcend the role of degradation stations, acting as key nodes for interorganelle crosstalk and signal transduction. Lysosomes communicate with the nucleus through physical proximity and functional interaction. In response to external and internal stimuli, lysosomes actively adjust their...