Conflicting Roles of Connexin43 in Tumor Invasion and Growth in the Central Nervous System

• Published in: International journal of molecular sciences Vol. 19; no. 4; p. 1159
• Main Authors: Uzu, Miaki, Sin, Wun Chey, Shimizu, Ayaka, Sato, Hiromi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 11.04.2018; MDPI AG
• Subjects: Animals; astrocyte; Astrocytes - metabolism; Astrocytes - pathology; Blood-Brain Barrier - metabolism; blood–brain barrier; central nervous system; Central Nervous System Neoplasms - metabolism; Central Nervous System Neoplasms - pathology; Connexin 43 - metabolism; connexin43; Gap Junctions - metabolism; glioma; Humans; Neoplasm Invasiveness; neurovascular unit; Review; glioma; blood–brain barrier; connexin43; astrocyte; central nervous system; neurovascular unit

The tumor microenvironment is known to have increased levels of cytokines and metabolites, such as glutamate, due to their release from the surrounding cells. A normal cell around the tumor that responds to the inflammatory environment is likely to be subsequently altered. We discuss how these abnor...