Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential

• Published in: Biomedicine & pharmacotherapy Vol. 133; p. 111072
• Main Authors: Zhang, Yukun, Lu, Peng, Qin, Huan, Zhang, Yuelin, Sun, Xinru, Song, Xunan, Liu, Jingjing, Peng, Hui, Liu, Yiting, Nwafor, Ebuka Olisaemeka, Li, Jiawei, Liu, Zhidong
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.01.2021; The Authors. Published by Elsevier Masson SAS
• Subjects: COVID-19; COVID-19 - complications; Drug Compounding; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - therapeutic use; History, 15th Century; History, 16th Century; History, 17th Century; History, 18th Century; History, 19th Century; History, 20th Century; History, Ancient; History, Medieval; Humans; Idiopathic pulmonary fibrosis; Idiopathic Pulmonary Fibrosis - drug therapy; Idiopathic Pulmonary Fibrosis - etiology; Idiopathic Pulmonary Fibrosis - prevention & control; Medicine, Chinese Traditional - history; Medicine, Chinese Traditional - methods; Nebulizers and Vaporizers; Phytotherapy; Pulmonary drug delivery system; Respiratory Therapy; Traditional Chinese medicine; LN; TIMP-1; JNK; AKt; MDA; INF-γ; COVID-19; α-SMA; MDI; PI3K; QE; HELF; CUR; FGF; PDDS; ANG-(1-7); MAPK; EMT; IL-6; MMP; TGF; SAB; HSP-47; DPI; TCM; ERK; HLF; Col III; Idiopathic pulmonary fibrosis; LPO; Pulmonary drug delivery system; S1P; Nrf2; SphK1; GA; GSH; HYP; HSP90; ASV; PMDI; VASH; Traditional Chinese medicine; NEB; ECM; Smad3; TNF-α; PDGF; NOX4; HA; FOXO3a; ACE-2; IPF

[Display omitted] •Pathogenesis and characteristics of idiopathic pulmonary fibrosis (IPF) are presented.•The history and current situation of traditional Chinese medicine (TCM) in treating lung diseases are introduced.•Therapeutic mechanisms of different TCM to treat IPF are summarized.•Advantages...