Preclinical and Clinical Applications of Metabolomics and Proteomics in Glioblastoma Research

Glioblastoma (GB) is a primary malignancy of the central nervous system that is classified by the WHO as a grade IV astrocytoma. Despite decades of research, several aspects about the biology of GB are still unclear. Its pathogenesis and resistance mechanisms are poorly understood, and methods to op...

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Published inInternational journal of molecular sciences Vol. 24; no. 1; p. 348
Main Authors Ahmed, Munazza, Semreen, Ahlam M, El-Huneidi, Waseem, Bustanji, Yasser, Abu-Gharbieh, Eman, Alqudah, Mohammad A Y, Alhusban, Ahmed, Shara, Mohd, Abuhelwa, Ahmad Y, Soares, Nelson C, Semreen, Mohammad H, Alzoubi, Karem H
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 25.12.2022
MDPI AG
Subjects
clinical applications
glioblastoma
metabolomics
omics
preclinical applications
proteomics
Review
preclinical applications
glioblastoma
pharmacometabolomics
omics
proteomics
clinical applications
metabolomics
biomarkers
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Abstract Glioblastoma (GB) is a primary malignancy of the central nervous system that is classified by the WHO as a grade IV astrocytoma. Despite decades of research, several aspects about the biology of GB are still unclear. Its pathogenesis and resistance mechanisms are poorly understood, and methods to optimize patient diagnosis and prognosis remain a bottle neck owing to the heterogeneity of the malignancy. The field of omics has recently gained traction, as it can aid in understanding the dynamic spatiotemporal regulatory network of enzymes and metabolites that allows cancer cells to adjust to their surroundings to promote tumor development. In combination with other omics techniques, proteomic and metabolomic investigations, which are a potent means for examining a variety of metabolic enzymes as well as intermediate metabolites, might offer crucial information in this area. Therefore, this review intends to stress the major contribution these tools have made in GB clinical and preclinical research and highlights the crucial impacts made by the integrative "omics" approach in reducing some of the therapeutic challenges associated with GB research and treatment. Thus, our study can purvey the use of these powerful tools in research by serving as a hub that particularly summarizes studies employing metabolomics and proteomics in the realm of GB diagnosis, treatment, and prognosis.
AbstractList Glioblastoma (GB) is a primary malignancy of the central nervous system that is classified by the WHO as a grade IV astrocytoma. Despite decades of research, several aspects about the biology of GB are still unclear. Its pathogenesis and resistance mechanisms are poorly understood, and methods to optimize patient diagnosis and prognosis remain a bottle neck owing to the heterogeneity of the malignancy. The field of omics has recently gained traction, as it can aid in understanding the dynamic spatiotemporal regulatory network of enzymes and metabolites that allows cancer cells to adjust to their surroundings to promote tumor development. In combination with other omics techniques, proteomic and metabolomic investigations, which are a potent means for examining a variety of metabolic enzymes as well as intermediate metabolites, might offer crucial information in this area. Therefore, this review intends to stress the major contribution these tools have made in GB clinical and preclinical research and highlights the crucial impacts made by the integrative “omics” approach in reducing some of the therapeutic challenges associated with GB research and treatment. Thus, our study can purvey the use of these powerful tools in research by serving as a hub that particularly summarizes studies employing metabolomics and proteomics in the realm of GB diagnosis, treatment, and prognosis.
Author Bustanji, Yasser
Alhusban, Ahmed
Alqudah, Mohammad A Y
Shara, Mohd
Abu-Gharbieh, Eman
Ahmed, Munazza
Semreen, Mohammad H
Abuhelwa, Ahmad Y
Soares, Nelson C
Semreen, Ahlam M
Alzoubi, Karem H
El-Huneidi, Waseem
AuthorAffiliation 3 Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates
5 School of Pharmacy, The University of Jordan, Amman 11942, Jordan
4 Department of Basic and Clinical Pharmacology, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates
1 Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates
8 Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates
6 Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates
7 Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan
2 Research Institute for Medical Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates
AuthorAffiliation_xml – name: 4 Department of Basic and Clinical Pharmacology, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates
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Issue 1
Keywords preclinical applications
glioblastoma
pharmacometabolomics
omics
proteomics
clinical applications
metabolomics
biomarkers
Language English
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Snippet Glioblastoma (GB) is a primary malignancy of the central nervous system that is classified by the WHO as a grade IV astrocytoma. Despite decades of research,...
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SubjectTerms clinical applications
glioblastoma
metabolomics
omics
preclinical applications
proteomics
Review
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Title Preclinical and Clinical Applications of Metabolomics and Proteomics in Glioblastoma Research
URI https://www.ncbi.nlm.nih.gov/pubmed/36613792
https://search.proquest.com/docview/2761981610
https://pubmed.ncbi.nlm.nih.gov/PMC9820403
https://doaj.org/article/c6d14bf30a6b4fdfa509a07ce9d606f7
Volume 24
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