Statistical differences in the white matter tracts in subjects with depression by using different skeletonized voxel-wise analysis approaches and DTI fitting procedures

• Published in: Brain research Vol. 1669; pp. 131 - 140
• Main Authors: Bergamino, Maurizio, Farmer, Madison, Yeh, Hung-wen, Paul, Elisabeth, Hamilton, J. Paul
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2017
• Subjects: Adult; Algorithms; ANTs; Brain - diagnostic imaging; Depressive Disorder, Major - diagnostic imaging; Diffusion Magnetic Resonance Imaging - methods; Diffusion tensor imaging; Diffusion Tensor Imaging - methods; DTI fitting algorithms; Female; Humans; Major depressive disorder; Middle Aged; Models, Statistical; Neurology; Psychiatric Status Rating Scales; TBSS; White Matter - diagnostic imaging; Young Adult; TBSS; ANTs; Major depressive disorder; Diffusion tensor imaging; DTI fitting algorithms

•We studied the differences between healthy control and depressed subjects by DTI.•Two different analysis methods and 12 different fitting algorithms were used.•Differences in DTI metrics were found between groups.•Our results depend on the DTI normalization and/or tensor fitting procedures used. Ma...