DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents

Fatty acids play a significant role in maintaining cellular and DNA protection and we previously found an inverse relationship between blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DNA damage. The aim of this study was to explore differences in proteomic profiles, fo...

Full description

Saved in:
Bibliographic Details
Published inNutrients Vol. 13; no. 8; p. 2483
Main Authors Barros, Tamiris Trevisan de, Venancio, Vinicius de Paula, Hernandes, Lívia Cristina, Antunes, Lusania Maria Greggi, Hillesheim, Elaine, Salomão, Roberta Garcia, Mathias, Mariana Giaretta, Coelho-Landell, Carolina Almeida, Toffano, Roseli Borges Donegá, Almada, Maria Olimpia Ribeiro do Vale, Camelo-Junior, José Simon, Moco, Sofia, Cominetti, Ornella, Ued, Fábio da Veiga, Kaput, Jim, Monteiro, Jacqueline Pontes
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 21.07.2021
MDPI
Subjects
Adolescents
Blood levels
Body mass index
Cell cycle
child
Children
Comet assay
Cyclin-dependent kinases
Damage detection
Deoxyribonucleic acid
DNA
DNA damage
Docosahexaenoic acid
Eicosapentaenoic acid
Ethylenediaminetetraacetic acid
Fatty acids
Gene expression
Inflammation
Nutrition
Omega-3 fatty acids
Physiology
Proteins
proteomic
Proteomics
Teenagers
Toxicity
Unsaturated fatty acids
Urban areas
Brazil
United States > US
Online AccessGet full text

Cover

Abstract Fatty acids play a significant role in maintaining cellular and DNA protection and we previously found an inverse relationship between blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DNA damage. The aim of this study was to explore differences in proteomic profiles, for 117 pro-inflammatory proteins, in two previously defined groups of individuals with different DNA damage and EPA and DHA levels. Healthy children and adolescents (n = 140) aged 9 to 13 years old in an urban area of Brazil were divided by k-means cluster test into two clusters of DNA damage (tail intensity) using the comet assay (cluster 1 = 5.9% ± 1.2 and cluster 2 = 13.8% ± 3.1) in our previous study. The cluster with higher DNA damage and lower levels of DHA (6.2 ± 1.6 mg/dL; 5.4 ± 1.3 mg/dL, p = 0.003) and EPA (0.6 ± 0.2 mg/dL; 0.5 ± 0.1 mg/dL, p < 0.001) presented increased expression of the proteins CDK8–CCNC, PIK3CA–PIK3R1, KYNU, and PRKCB, which are involved in pro-inflammatory pathways. Our findings support the hypothesis that low levels of n-3 long-chain PUFA may have a less protective role against DNA damage through expression of pro-inflammatory proteins, such as CDK8–CCNC, PIK3CA–PIK3R1, KYNU, and PRKCB.
AbstractList Fatty acids play a significant role in maintaining cellular and DNA protection and we previously found an inverse relationship between blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DNA damage. The aim of this study was to explore differences in proteomic profiles, for 117 pro-inflammatory proteins, in two previously defined groups of individuals with different DNA damage and EPA and DHA levels. Healthy children and adolescents (n = 140) aged 9 to 13 years old in an urban area of Brazil were divided by k-means cluster test into two clusters of DNA damage (tail intensity) using the comet assay (cluster 1 = 5.9% ± 1.2 and cluster 2 = 13.8% ± 3.1) in our previous study. The cluster with higher DNA damage and lower levels of DHA (6.2 ± 1.6 mg/dL; 5.4 ± 1.3 mg/dL, p = 0.003) and EPA (0.6 ± 0.2 mg/dL; 0.5 ± 0.1 mg/dL, p < 0.001) presented increased expression of the proteins CDK8–CCNC, PIK3CA–PIK3R1, KYNU, and PRKCB, which are involved in pro-inflammatory pathways. Our findings support the hypothesis that low levels of n-3 long-chain PUFA may have a less protective role against DNA damage through expression of pro-inflammatory proteins, such as CDK8–CCNC, PIK3CA–PIK3R1, KYNU, and PRKCB.
Fatty acids play a significant role in maintaining cellular and DNA protection and we previously found an inverse relationship between blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DNA damage. The aim of this study was to explore differences in proteomic profiles, for 117 pro-inflammatory proteins, in two previously defined groups of individuals with different DNA damage and EPA and DHA levels. Healthy children and adolescents ( n = 140) aged 9 to 13 years old in an urban area of Brazil were divided by k-means cluster test into two clusters of DNA damage (tail intensity) using the comet assay (cluster 1 = 5.9% ± 1.2 and cluster 2 = 13.8% ± 3.1) in our previous study. The cluster with higher DNA damage and lower levels of DHA (6.2 ± 1.6 mg/dL; 5.4 ± 1.3 mg/dL, p = 0.003) and EPA (0.6 ± 0.2 mg/dL; 0.5 ± 0.1 mg/dL, p < 0.001) presented increased expression of the proteins CDK8–CCNC, PIK3CA–PIK3R1, KYNU, and PRKCB, which are involved in pro-inflammatory pathways. Our findings support the hypothesis that low levels of n-3 long-chain PUFA may have a less protective role against DNA damage through expression of pro-inflammatory proteins, such as CDK8–CCNC, PIK3CA–PIK3R1, KYNU, and PRKCB.
Audience Academic
Author Cominetti, Ornella
Toffano, Roseli Borges Donegá
Hillesheim, Elaine
Mathias, Mariana Giaretta
Venancio, Vinicius de Paula
Barros, Tamiris Trevisan de
Coelho-Landell, Carolina Almeida
Moco, Sofia
Antunes, Lusania Maria Greggi
Camelo-Junior, José Simon
Monteiro, Jacqueline Pontes
Almada, Maria Olimpia Ribeiro do Vale
Hernandes, Lívia Cristina
Ued, Fábio da Veiga
Salomão, Roberta Garcia
Kaput, Jim
AuthorAffiliation 2 School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Sao Paulo 14049-900, Brazil; venancio.vinicius@alumni.usp.br (V.d.P.V.); lusania@fcfrp.usp.br (L.M.G.A.)
1 Department of Pediatrics, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo 14049-900, Brazil; elainehillesheim@usp.br (E.H.); rsalomao@usp.br (R.G.S.); marimathias@hotmail.com (M.G.M.); k_rolacoelho@hotmail.com (C.A.C.-L.); roselibdt@hotmail.com (R.B.D.T.); madovale@yahoo.com.br (M.O.R.d.V.A.); jscamelo@fmrp.usp.br (J.S.C.-J.); jacque@fmrp.usp.br (J.P.M.)
3 Nestlé Research, Société des Produits Nestlé SA, EPFL Innovation Park, CH1015 Lausanne, Switzerland; s.moco@vu.nl (S.M.); ornella.cominetti@rd.nestle.com (O.C.); jkaput@gmail.com (J.K.)
4 Department of Health Sciences, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo 14049-900, Brazil; uedfabio@gmail.com
AuthorAffiliation_xml – name: 4 Department of Health Sciences, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo 14049-900, Brazil; uedfabio@gmail.com
– name: 2 School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Sao Paulo 14049-900, Brazil; venancio.vinicius@alumni.usp.br (V.d.P.V.); lusania@fcfrp.usp.br (L.M.G.A.)
– name: 1 Department of Pediatrics, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo 14049-900, Brazil; elainehillesheim@usp.br (E.H.); rsalomao@usp.br (R.G.S.); marimathias@hotmail.com (M.G.M.); k_rolacoelho@hotmail.com (C.A.C.-L.); roselibdt@hotmail.com (R.B.D.T.); madovale@yahoo.com.br (M.O.R.d.V.A.); jscamelo@fmrp.usp.br (J.S.C.-J.); jacque@fmrp.usp.br (J.P.M.)
– name: 3 Nestlé Research, Société des Produits Nestlé SA, EPFL Innovation Park, CH1015 Lausanne, Switzerland; s.moco@vu.nl (S.M.); ornella.cominetti@rd.nestle.com (O.C.); jkaput@gmail.com (J.K.)
Author_xml – sequence: 1
  fullname: Barros, Tamiris Trevisan de
– sequence: 2
  fullname: Venancio, Vinicius de Paula
– sequence: 3
  fullname: Hernandes, Lívia Cristina
– sequence: 4
  fullname: Antunes, Lusania Maria Greggi
– sequence: 5
  fullname: Hillesheim, Elaine
– sequence: 6
  fullname: Salomão, Roberta Garcia
– sequence: 7
  fullname: Mathias, Mariana Giaretta
– sequence: 8
  fullname: Coelho-Landell, Carolina Almeida
– sequence: 9
  fullname: Toffano, Roseli Borges Donegá
– sequence: 10
  fullname: Almada, Maria Olimpia Ribeiro do Vale
– sequence: 11
  fullname: Camelo-Junior, José Simon
– sequence: 12
  fullname: Moco, Sofia
– sequence: 13
  fullname: Cominetti, Ornella
– sequence: 14
  fullname: Ued, Fábio da Veiga
– sequence: 15
  fullname: Kaput, Jim
– sequence: 16
  fullname: Monteiro, Jacqueline Pontes
BookMark eNptkk1v1DAQhi1UREvphV8QiQtCpPgrjnNBSrcUKq2gB3q2Jv7IepW1i5NUgl-P060oi7APHtnPvNY7My_RUYjBIvSa4HPGGvwhzIRhSblkz9AJxTUtheDs6K_4GJ2N4xYvq8a1YC_QMeN5CU5PUHf5tS0uYQe9fV-EkhXrGPpytQEfipvbq7ZY23s7jAUEU9ykONm483qJnB9skaGLBL_84CEUq40fTLLhgW1NHOyobZjGV-i5g2G0Z4_nKbq9-vR99aVcf_t8vWrXpa6ImMrGOas7o7nsJHa2NtI4obFmonNOVlJ2tDGugS67xkTTiuGKNdSYmjHQQNkput7rmghbdZf8DtJPFcGrh4uYegVp8nqwSlACmHPLCa045ayzjmnghOsGGgCZtT7ute7mbmfN4iPBcCB6-BL8RvXxXkmOSVOTLPD2USDFH7MdJ7XzuRzDAMHGeVS0EgLTJrcuo2_-QbdxTiGXaqEqLjFh4onqIRvwwcX8r15EVVuLSnBeE5yp8_9QeRub-5YnZ2nbYcK7fYJOcRyTdX88EqyWAVNPA8Z-AxF0v44
CitedBy_id crossref_primary_10_3390_nu16020188
Cites_doi 10.1080/21541264.2018.1556915
10.1016/j.cell.2017.07.029
10.1016/0014-4827(88)90265-0
10.1089/ars.2017.7269
10.3390/ijms18081808
10.3389/fonc.2018.00160
10.1016/j.redox.2020.101581
10.3390/nu11122918
10.1073/pnas.1206906109
10.1016/j.molcel.2015.05.006
10.2174/156800961508151001105814
10.1016/j.jnutbio.2018.05.002
10.3390/ijms18081784
10.1172/JCI61462
10.1016/j.jaci.2015.09.055
10.1007/s00702-011-0681-y
10.1093/oxfordjournals.jbchem.a003273
10.1590/S0004-27302010000700002
10.1007/s00726-010-0787-9
10.1194/jlr.M400444-JLR200
10.1158/2159-8290.CD-19-0528
10.1097/MOL.0000000000000262
10.1038/nsmb.1752
10.1039/C9FO02551K
10.1021/pr1004339
10.1186/s12199-018-0740-1
10.4103/1673-5374.198971
10.1016/j.celrep.2016.03.030
10.1016/j.vph.2015.03.016
10.20960/nh.2119
10.1016/j.dnarep.2014.01.016
10.2471/BLT.07.043497
10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J
10.3389/fcell.2018.00171
10.1016/S1097-2765(03)00359-9
10.1194/jlr.D500022-JLR200
10.4161/trns.1.1.12373
10.1002/mnfr.201700613
10.1016/j.mrfmmm.2010.12.016
10.3390/molecules23010191
10.1371/journal.pone.0015004
10.1016/j.ctrv.2020.102021
10.3945/an.117.015610
10.1016/j.cell.2009.03.048
10.1590/S0001-37652012005000039
10.1007/s10565-007-9043-9
10.2741/Bregman
10.1586/erm.10.89
10.1534/g3.119.400077
10.1002/pmic.201600018
10.1002/iub.1428
10.1002/bab.2104
10.1152/ajpheart.00629.2019
10.1080/07315724.2002.10719248
10.1111/ced.14072
10.1074/jbc.RA120.015215
10.1016/j.mrrev.2003.11.001
10.4161/auto.25239
10.1002/hep.32008
10.1016/j.mrfmmm.2004.11.003
10.1158/0008-5472.CAN-18-1583
10.1111/php.12337
10.1186/s12943-019-0954-x
ContentType Journal Article
Copyright COPYRIGHT 2021 MDPI AG
2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 by the authors. 2021
Copyright_xml – notice: COPYRIGHT 2021 MDPI AG
– notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2021 by the authors. 2021
DBID AAYXX
CITATION
3V.
7TS
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.3390/nu13082483
DatabaseName CrossRef
ProQuest Central (Corporate)
Physical Education Index
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
Publicly Available Content (ProQuest)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
Physical Education Index
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

CrossRef

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: 7X7
  name: ProQuest Health and Medical
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 2072-6643
ExternalDocumentID oai_doaj_org_article_621a044e41254243bef3ca414c9a9aa8
A765644710
10_3390_nu13082483
GeographicLocations Brazil
United States--US
GeographicLocations_xml – name: Brazil
– name: United States--US
GroupedDBID ---
3V.
53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
A8Z
AADQD
AAFWJ
AAHBH
AAWTL
AAYXX
ABUWG
ACIWK
ACPRK
AENEX
AFKRA
AFRAH
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
APEBS
ATCPS
BBNVY
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CITATION
DIK
E3Z
EBD
ECGQY
EIHBH
ESTFP
EYRJQ
F5P
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
ITC
KQ8
LK8
M0K
M1P
M48
M7P
MODMG
M~E
OK1
P2P
P6G
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RPM
TR2
UKHRP
RIG
7TS
7XB
8FK
AZQEC
DWQXO
K9.
PQEST
PQUKI
PRINS
7X8
5PM
AFPKN
ID FETCH-LOGICAL-c516t-9ffecbdc48b80fe7d8df6c0c36bff8588b29df9ab39001c25305392dd733aca23
IEDL.DBID RPM
ISSN 2072-6643
IngestDate Tue Oct 22 15:14:55 EDT 2024
Tue Sep 17 21:37:23 EDT 2024
Wed Dec 04 09:51:21 EST 2024
Sat Dec 14 10:28:10 EST 2024
Tue Nov 19 21:41:43 EST 2024
Wed Nov 13 00:24:06 EST 2024
Fri Dec 06 09:16:18 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c516t-9ffecbdc48b80fe7d8df6c0c36bff8588b29df9ab39001c25305392dd733aca23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Current address: Vydiant, Folsom, CA 95630-2599, USA.
Current address: Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
ORCID 0000-0002-1459-2233
0000-0002-3079-4388
0000-0001-6147-3491
0000-0003-3239-6380
0000-0001-7141-7776
0000-0003-2184-4977
0000-0002-2138-3181
0000-0001-8170-8876
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401971/
PMID 34444642
PQID 2565480136
PQPubID 2032353
ParticipantIDs doaj_primary_oai_doaj_org_article_621a044e41254243bef3ca414c9a9aa8
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8401971
proquest_miscellaneous_2566029308
proquest_journals_2565480136
gale_infotracmisc_A765644710
gale_infotracacademiconefile_A765644710
crossref_primary_10_3390_nu13082483
PublicationCentury 2000
PublicationDate 20210721
PublicationDateYYYYMMDD 2021-07-21
PublicationDate_xml – month: 7
  year: 2021
  text: 20210721
  day: 21
PublicationDecade 2020
PublicationPlace Basel
PublicationPlace_xml – name: Basel
PublicationTitle Nutrients
PublicationYear 2021
Publisher MDPI AG
MDPI
Publisher_xml – sequence: 0
  name: MDPI AG
– name: MDPI AG
– name: MDPI
References Kussmann (ref_4) 2010; 9
Rai (ref_11) 2007; 4
Porter (ref_50) 2012; 109
Patergnani (ref_43) 2013; 9
Gomes (ref_67) 2018; 58
ref_55
Harden (ref_39) 2016; 137
ref_19
Elia (ref_15) 2016; 59
Savoye (ref_20) 2015; 67
ref_59
(ref_63) 2012; 119
Onyango (ref_24) 2007; 85
Dannappel (ref_37) 2019; 6
Chou (ref_12) 2020; 10
Singh (ref_27) 1988; 175
Kawakami (ref_42) 2002; 132
Masood (ref_25) 2005; 46
Murata (ref_18) 2018; 23
Tice (ref_28) 2000; 35
Maia (ref_48) 2002; 48
Huang (ref_10) 2020; 86
Kolodziej (ref_64) 2011; 41
Stieg (ref_38) 2019; 9
Donner (ref_46) 2010; 17
Espinosa (ref_47) 2003; 12
ref_23
Athar (ref_58) 2015; 91
Sakata (ref_69) 2015; 70
ref_21
Koundouros (ref_56) 2018; 8
Kumaravel (ref_29) 2009; 25
Barros (ref_16) 2020; 11
ref_26
Braidy (ref_65) 2017; 12
Braidy (ref_66) 2019; 30
Kim (ref_62) 2015; 2015
Liang (ref_35) 2018; 78
Galbraith (ref_33) 2010; 1
Slyskova (ref_5) 2014; 16
Davidson (ref_70) 2000; 21
Broude (ref_36) 2015; 15
Ci (ref_40) 2020; 45
Sheak (ref_68) 2020; 318
ref_31
Mathew (ref_57) 2009; 137
Corella (ref_3) 2018; 35
Simopoulos (ref_61) 2002; 21
Mathias (ref_22) 2018; 62
Fenech (ref_9) 2017; 8
Poss (ref_49) 2016; 15
Ziegler (ref_14) 2020; 37
Kryston (ref_6) 2011; 711
Bregman (ref_34) 2000; 5
Yang (ref_53) 2019; 18
Donato (ref_54) 2010; 54
Demirbag (ref_8) 2005; 570
Fant (ref_32) 2019; 10
Kliemann (ref_71) 2012; 84
Fruman (ref_41) 2017; 170
(ref_1) 2014; 48
ref_45
Olsen (ref_13) 2017; 17
ref_44
Denys (ref_60) 2005; 46
Evans (ref_7) 2004; 567
Brody (ref_30) 2010; 10
Zhao (ref_52) 2012; 122
Pisabarro (ref_2) 2006; 22
Barden (ref_17) 2016; 27
Stieg (ref_51) 2020; 295
References_xml – volume: 10
  start-page: 76
  year: 2019
  ident: ref_32
  article-title: Regulatory functions of the Mediator kinases CDK8 and CDK19
  publication-title: Transcription
  doi: 10.1080/21541264.2018.1556915
  contributor:
    fullname: Fant
– volume: 48
  start-page: 419
  year: 2002
  ident: ref_48
  article-title: p53 in hematological malignancies
  publication-title: Rev. Bras. Cancerol.
  contributor:
    fullname: Maia
– volume: 170
  start-page: 605
  year: 2017
  ident: ref_41
  article-title: The PI3K Pathway in Human Disease
  publication-title: Cell
  doi: 10.1016/j.cell.2017.07.029
  contributor:
    fullname: Fruman
– volume: 175
  start-page: 184
  year: 1988
  ident: ref_27
  article-title: A simple technique for quantitation of low levels of DNA damage in individual cells
  publication-title: Exp. Cell Res.
  doi: 10.1016/0014-4827(88)90265-0
  contributor:
    fullname: Singh
– volume: 30
  start-page: 251
  year: 2019
  ident: ref_66
  article-title: Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2017.7269
  contributor:
    fullname: Braidy
– ident: ref_19
  doi: 10.3390/ijms18081808
– volume: 8
  start-page: 2
  year: 2018
  ident: ref_56
  article-title: Phosphoinositide 3-Kinase/Akt signaling and redox metabolism in cancer
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2018.00160
  contributor:
    fullname: Koundouros
– volume: 37
  start-page: 101581
  year: 2020
  ident: ref_14
  article-title: Chemical modification of pro-inflammatory proteins by peroxynitrite increases activation of TLR4 and NF-κB: Implications for the health effects of air pollution and oxidative stress
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2020.101581
  contributor:
    fullname: Ziegler
– ident: ref_26
  doi: 10.3390/nu11122918
– volume: 109
  start-page: 13799
  year: 2012
  ident: ref_50
  article-title: Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities
  publication-title: PNAS
  doi: 10.1073/pnas.1206906109
  contributor:
    fullname: Porter
– volume: 59
  start-page: 867
  year: 2016
  ident: ref_15
  article-title: Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2015.05.006
  contributor:
    fullname: Elia
– volume: 21
  start-page: 1513
  year: 2000
  ident: ref_70
  article-title: Morphodensitometric analysis of protein kinase C β II expression in rat colon: Modulation by diet and relation to in situ cell proliferation and apoptosis
  publication-title: Carcinogenesis
  contributor:
    fullname: Davidson
– volume: 15
  start-page: 739
  year: 2015
  ident: ref_36
  article-title: Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer
  publication-title: Curr. Cancer Drug Targets
  doi: 10.2174/156800961508151001105814
  contributor:
    fullname: Broude
– volume: 58
  start-page: 37
  year: 2018
  ident: ref_67
  article-title: Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2018.05.002
  contributor:
    fullname: Gomes
– ident: ref_21
  doi: 10.3390/ijms18081784
– ident: ref_23
– volume: 122
  start-page: 2417
  year: 2012
  ident: ref_52
  article-title: Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI61462
  contributor:
    fullname: Zhao
– volume: 137
  start-page: 1830
  year: 2016
  ident: ref_39
  article-title: The Tryptophan Metabolism Enzyme, L-Kynureninase, is a Novel Inflammatory Factor in Psoriasis and other Inflammatory Diseases
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2015.09.055
  contributor:
    fullname: Harden
– volume: 2015
  start-page: 239764
  year: 2015
  ident: ref_62
  article-title: Docosahexaenoic acid induces cell death in human non-small cell lung cancer cells by repressing mTOR via AMPK activation and PI3K/Akt inhibition
  publication-title: Biomed Res. Int.
  contributor:
    fullname: Kim
– volume: 119
  start-page: 197
  year: 2012
  ident: ref_63
  article-title: The kynurenine system and immunoregulation
  publication-title: J. Neural. Transm.
  doi: 10.1007/s00702-011-0681-y
– volume: 132
  start-page: 677
  year: 2002
  ident: ref_42
  article-title: Protein kinase C beta (PKC beta): Normal functions and diseases
  publication-title: J. Biochem.
  doi: 10.1093/oxfordjournals.jbchem.a003273
  contributor:
    fullname: Kawakami
– volume: 54
  start-page: 591
  year: 2010
  ident: ref_54
  article-title: The PI3K signaling pathway mediates the biological effects of leptin
  publication-title: Arq. Bras. Endocrinol. Metabol.
  doi: 10.1590/S0004-27302010000700002
  contributor:
    fullname: Donato
– volume: 41
  start-page: 1173
  year: 2011
  ident: ref_64
  article-title: Kynurenine metabolism in health and disease
  publication-title: Amino Acids
  doi: 10.1007/s00726-010-0787-9
  contributor:
    fullname: Kolodziej
– volume: 46
  start-page: 752
  year: 2005
  ident: ref_60
  article-title: n-3 PUFAs modulate T-cell activation via protein kinase C-α and -ε and the NF-κB signaling pathway
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M400444-JLR200
  contributor:
    fullname: Denys
– volume: 10
  start-page: 351
  year: 2020
  ident: ref_12
  article-title: Transcription-associated cyclin-dependent kinases as targets and biomarkers for cancer therapy
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-19-0528
  contributor:
    fullname: Chou
– volume: 27
  start-page: 26
  year: 2016
  ident: ref_17
  article-title: n-3 Fatty acid supplementation and proresolving mediators of inflammation
  publication-title: Curr. Opin. Lipidol.
  doi: 10.1097/MOL.0000000000000262
  contributor:
    fullname: Barden
– volume: 17
  start-page: 194
  year: 2010
  ident: ref_46
  article-title: CDK8 is a positive regulator of transcriptional elongation within the serum response network
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1752
  contributor:
    fullname: Donner
– volume: 11
  start-page: 5115
  year: 2020
  ident: ref_16
  article-title: DNA damage is inversely associated to blood levels of DHA and EPA fatty acids in Brazilian children and adolescents
  publication-title: Food Funct.
  doi: 10.1039/C9FO02551K
  contributor:
    fullname: Barros
– volume: 9
  start-page: 4876
  year: 2010
  ident: ref_4
  article-title: Proteomics in nutrition: Status quo and outlook for biomarkers and bioactives
  publication-title: J. Proteome Res.
  doi: 10.1021/pr1004339
  contributor:
    fullname: Kussmann
– volume: 23
  start-page: 50
  year: 2018
  ident: ref_18
  article-title: Inflammation and Cancer
  publication-title: Environ. Health Prev. Med.
  doi: 10.1186/s12199-018-0740-1
  contributor:
    fullname: Murata
– volume: 12
  start-page: 39
  year: 2017
  ident: ref_65
  article-title: Kynurenine pathway metabolism and neuroinflammatory disease
  publication-title: Neural Regen. Res.
  doi: 10.4103/1673-5374.198971
  contributor:
    fullname: Braidy
– volume: 4
  start-page: 99
  year: 2007
  ident: ref_11
  article-title: DNA damage response: The players, the network and the role in tumor suppression
  publication-title: Cancer Genom. Proteom.
  contributor:
    fullname: Rai
– volume: 15
  start-page: 436
  year: 2016
  ident: ref_49
  article-title: Identification of Mediator kinase substrates in human cells using cortistatin A and quantitative phosphoproteomics
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.03.030
  contributor:
    fullname: Poss
– volume: 70
  start-page: 55
  year: 2015
  ident: ref_69
  article-title: Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells
  publication-title: Vascul. Pharmacol.
  doi: 10.1016/j.vph.2015.03.016
  contributor:
    fullname: Sakata
– volume: 35
  start-page: 10
  year: 2018
  ident: ref_3
  article-title: Papel de las ómicas en la nutrición de precisión: Fortalezas y debilidades
  publication-title: Nutr. Hosp.
  doi: 10.20960/nh.2119
  contributor:
    fullname: Corella
– volume: 16
  start-page: 66
  year: 2014
  ident: ref_5
  article-title: Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity
  publication-title: DNA Repair
  doi: 10.1016/j.dnarep.2014.01.016
  contributor:
    fullname: Slyskova
– volume: 85
  start-page: 660
  year: 2007
  ident: ref_24
  article-title: Development of a WHO growth reference for school-aged children and adolescents
  publication-title: Bull. World Health Organ.
  doi: 10.2471/BLT.07.043497
  contributor:
    fullname: Onyango
– volume: 22
  start-page: 100
  year: 2006
  ident: ref_2
  article-title: Nutrigenética y nutrigenómica la revolución sanitaria del nuevo milenio. Implicancias clínicas en síndrome metabólico y diabetes tipo 2
  publication-title: Rev. Médica Urug.
  contributor:
    fullname: Pisabarro
– volume: 35
  start-page: 206
  year: 2000
  ident: ref_28
  article-title: Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
  publication-title: Environ. Mol. Mutagen.
  doi: 10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J
  contributor:
    fullname: Tice
– volume: 6
  start-page: 1
  year: 2019
  ident: ref_37
  article-title: Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2018.00171
  contributor:
    fullname: Dannappel
– volume: 12
  start-page: 1015
  year: 2003
  ident: ref_47
  article-title: p53 Functions through Stress- and Promoter- Specific Recruitment of Transcription Initiation Components before and after DNA Damage
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(03)00359-9
  contributor:
    fullname: Espinosa
– volume: 46
  start-page: 2299
  year: 2005
  ident: ref_25
  article-title: A simplified and efficient method for the analysis of fatty acid methyl esters suitable for large clinical studies
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.D500022-JLR200
  contributor:
    fullname: Masood
– volume: 1
  start-page: 4
  year: 2010
  ident: ref_33
  article-title: CDK8: A positive regulator of transcription
  publication-title: Transcription
  doi: 10.4161/trns.1.1.12373
  contributor:
    fullname: Galbraith
– volume: 62
  start-page: 1700613
  year: 2018
  ident: ref_22
  article-title: Clinical and Vitamin Response to a Short-Term Multi-Micronutrient Intervention in Brazilian Children and Teens: From Population Data to Interindividual Responses
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.201700613
  contributor:
    fullname: Mathias
– volume: 711
  start-page: 193
  year: 2011
  ident: ref_6
  article-title: Role of oxidative stress and DNA damage in human carcinogenesis
  publication-title: Mutat. Res.
  doi: 10.1016/j.mrfmmm.2010.12.016
  contributor:
    fullname: Kryston
– ident: ref_45
  doi: 10.3390/molecules23010191
– ident: ref_31
  doi: 10.1371/journal.pone.0015004
– volume: 86
  start-page: 102021
  year: 2020
  ident: ref_10
  article-title: Targeting the PI3K pathway and DNA damage response as a therapeutic strategy in ovarian cancer
  publication-title: Cancer Treat. Rev.
  doi: 10.1016/j.ctrv.2020.102021
  contributor:
    fullname: Huang
– volume: 8
  start-page: 958
  year: 2017
  ident: ref_9
  article-title: Vitamins Associated with Brain Aging, Mild Cognitive Impairment, and Alzheimer Disease: Biomarkers, Epidemiological and Experimental Evidence, Plausible Mechanisms, and Knowledge Gaps
  publication-title: Adv. Nutr.
  doi: 10.3945/an.117.015610
  contributor:
    fullname: Fenech
– volume: 137
  start-page: 1062
  year: 2009
  ident: ref_57
  article-title: Autophagy Suppresses Tumorigenesis through Elimination of p62
  publication-title: Cell
  doi: 10.1016/j.cell.2009.03.048
  contributor:
    fullname: Mathew
– volume: 84
  start-page: 833
  year: 2012
  ident: ref_71
  article-title: DNA damage in children and adolescents with cardiovascular disease risk factors
  publication-title: An. Acad. Bras. Cienc.
  doi: 10.1590/S0001-37652012005000039
  contributor:
    fullname: Kliemann
– ident: ref_44
– volume: 25
  start-page: 53
  year: 2009
  ident: ref_29
  article-title: Comet Assay measurements: A perspective
  publication-title: Cell Biol. Toxicol.
  doi: 10.1007/s10565-007-9043-9
  contributor:
    fullname: Kumaravel
– volume: 5
  start-page: D244
  year: 2000
  ident: ref_34
  article-title: Cell cycle regulation and RNA polymerase II
  publication-title: Front. Biosci.
  doi: 10.2741/Bregman
  contributor:
    fullname: Bregman
– volume: 10
  start-page: 1013
  year: 2010
  ident: ref_30
  article-title: High-content affinity-based proteomics: Unlocking protein biomarker discovery
  publication-title: Expert Rev. Mol. Diagn.
  doi: 10.1586/erm.10.89
  contributor:
    fullname: Brody
– volume: 9
  start-page: 1901
  year: 2019
  ident: ref_38
  article-title: Cyclin C regulated oxidative stress responsive transcriptome in mus musculus embryonic fibroblasts
  publication-title: G3 Genes Genomes Genet.
  doi: 10.1534/g3.119.400077
  contributor:
    fullname: Stieg
– volume: 17
  start-page: 1600018
  year: 2017
  ident: ref_13
  article-title: Proteomics insights into DNA damage response and translating this knowledge to clinical strategies
  publication-title: Proteomics
  doi: 10.1002/pmic.201600018
  contributor:
    fullname: Olsen
– volume: 67
  start-page: 659
  year: 2015
  ident: ref_20
  article-title: Polyunsaturated fatty acids and inflammation
  publication-title: IUBMB Life
  doi: 10.1002/iub.1428
  contributor:
    fullname: Savoye
– ident: ref_55
  doi: 10.1002/bab.2104
– volume: 318
  start-page: H470
  year: 2020
  ident: ref_68
  article-title: PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00629.2019
  contributor:
    fullname: Sheak
– volume: 21
  start-page: 495
  year: 2002
  ident: ref_61
  article-title: Omega-3 fatty acids in inflammation and autoimmune diseases
  publication-title: J. Am. Coll. Nutr.
  doi: 10.1080/07315724.2002.10719248
  contributor:
    fullname: Simopoulos
– volume: 45
  start-page: 194
  year: 2020
  ident: ref_40
  article-title: Downregulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses the PI3K/AKT pathway
  publication-title: Clin. Exp. Dermatol.
  doi: 10.1111/ced.14072
  contributor:
    fullname: Ci
– volume: 295
  start-page: 16280
  year: 2020
  ident: ref_51
  article-title: The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA120.015215
  contributor:
    fullname: Stieg
– volume: 567
  start-page: 1
  year: 2004
  ident: ref_7
  article-title: Oxidative DNA damage and disease: Induction, repair and significance
  publication-title: Mutat. Res.
  doi: 10.1016/j.mrrev.2003.11.001
  contributor:
    fullname: Evans
– volume: 9
  start-page: 1367
  year: 2013
  ident: ref_43
  article-title: PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy
  publication-title: Autophagy
  doi: 10.4161/auto.25239
  contributor:
    fullname: Patergnani
– ident: ref_59
  doi: 10.1002/hep.32008
– volume: 48
  start-page: 375
  year: 2014
  ident: ref_1
  article-title: Genómica nutricional como control de la enfermedad cardiovascular en el futuro próximo
  publication-title: Acta Bioquim. Clin. Lat.
– volume: 570
  start-page: 197
  year: 2005
  ident: ref_8
  article-title: Relationship between DNA damage, total antioxidant capacity and coronary artery disease
  publication-title: Mutat. Res.
  doi: 10.1016/j.mrfmmm.2004.11.003
  contributor:
    fullname: Demirbag
– volume: 78
  start-page: 6594
  year: 2018
  ident: ref_35
  article-title: CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-18-1583
  contributor:
    fullname: Liang
– volume: 91
  start-page: 225
  year: 2015
  ident: ref_58
  article-title: Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless mice
  publication-title: Photochem. Photobiol.
  doi: 10.1111/php.12337
  contributor:
    fullname: Athar
– volume: 18
  start-page: 26
  year: 2019
  ident: ref_53
  article-title: Targeting PI3K in cancer: Mechanisms and advances in clinical trials
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-019-0954-x
  contributor:
    fullname: Yang
SSID ssj0000070763
Score 2.3259265
Snippet Fatty acids play a significant role in maintaining cellular and DNA protection and we previously found an inverse relationship between blood levels of...
SourceID doaj
pubmedcentral
proquest
gale
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 2483
SubjectTerms Adolescents
Blood levels
Body mass index
Cell cycle
child
Children
Comet assay
Cyclin-dependent kinases
Damage detection
Deoxyribonucleic acid
DNA
DNA damage
Docosahexaenoic acid
Eicosapentaenoic acid
Ethylenediaminetetraacetic acid
Fatty acids
Gene expression
Inflammation
Nutrition
Omega-3 fatty acids
Physiology
Proteins
proteomic
Proteomics
Teenagers
Toxicity
Unsaturated fatty acids
Urban areas
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELVQT70goEUESmUEggtR_RU7OaZbVlVVqh5YqbfIn7SHelG7e6C_vjNJ2m7gwIVbFE8k500mfmPNPBPySbpKJhF8aSqLR5hxXTrFUhkqIPso2KYS7kN-P9PHC3VyUV1sHPWFNWGDPPAA3IEW3DKlooKVWAklXUzSW8WVb2xj7dDmy8RGMjUQXwMJuhz0SCXk9Qd5zVGZRdVysgL1Qv1__47_LJHcWHPmL8jzkSzSdpjkS_Is5ldkp82QKF__pp9pX77Z74vvEHd01tIjew3_h680l5KeLvPPcnYJmT89X8xbeorlQbfU5kDPUZwB25HxCpWZKBgd3ti7K9z0oLOxwbu3bZ8kn3bJYv7tx-y4HA9QKH3F9apssCTEBa9qV7MUTahD0p55qV1KdVXXTjQhNdYBQIx7UUHwA18KwUhpvRXyNdnKyxzfEBodOo95I4BzRK4bb7kJTQ0ExNZayoJ8fAC1-zXoZHSQXyD03RP0BTlEvB8tUNu6vwEe70aPd__yeEG-oLc6jEDwjbdjIwFMFBHrWgMcVcGiywqyN7GEyPHT4Qd_d2Pk3nZAAVECj0tdkA-Pw_gkVqPluFz3NpoBT2IwFzP5TiZvNh3JV5e9ejdk1Lwx_O3_gOId2RZYY8NMKfge2VrdrON7IEkrt9_Hwz3kDQ2p
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagXLggoCACBRmB4IJVv2I7J5RuWVWoVD2w0t4iP5K2hyZlHwf49cxks7sEJG6r9azWmbFnvpmMPxPyXoVcNTJFZnOPV5gJw4LmDUs5gH0kbNMN1iG_XZizmf46z-dDwW05tFVufWLvqFMXsUZ-DKEZqcmEMp_vfjC8NQrfrg5XaNwnD4SEUA7r2c7trsbSc9kYtWElVZDdH7drgfws2qlRHOrp-v91yn83Sv4ReaaPyaMBMtJyY-Mn5F7dPiWHZQvp8u1P-oH2TZx9dfyQhNOLkp76W_ASn2jLFD3v2is2uYb8n17OpiU9xyahJfVtopdI0YCHkvET8jNREDpZ-F83WPqgk-GYdy9b7omfnpHZ9Mv3yRkbrlFgMRdmxQpsDAkpahccb2qbXGpM5FGZ0DQudy7IIjWFD6AgLqLMwQUAakrJKuWjl-o5OWi7tn5BaB3QhDxaCcijFqaIXthUOIAh3hmlMvJuq9TqbsOWUUGWgaqv9qrPyAnqeyeBDNf9F93iqho2TGWk8FzrWgMC01KrUDcqei10LHzhvcvIR7RWhfsQbBP9cJwAJooaq0oLSFVD6OUZORpJwv6J4-Gtvath_y6r_WrLyNvdMP4Se9Laulv3MoYDWuIwFztaJ6MnG4-0N9c9hzfk1aKw4uX___wVeSixh4ZbJsUROVgt1vVrAEGr8KZf6b8BG1UFlw
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkVAvCCiIQEFGILgQ8Cu2c0Ao3bKqUFv1wEq9RX4k7UqtF7a7EuXXM5PNtqRwIqcoHkvOjMf-xhp_Q8gb6QvZihhyUzgsYcZ17hVr81gA2EfCNtXiOeThkd6fqK8nxckGWdfv7BV4-c_QDutJTebnH37-uPoMDv8JI04I2T-mJUfSFWXlHXJXwI6IqV2HPcxfwWAD4bpcsZPe6rJF7kkFj1ZisDV1DP5_r9O3cyf_2IzGD8j9HkXSamX2h2SjSY_IdpUggr64om9pl9fZHZhvE793VNE9dwELx3uackkPZuk0H525aaLHk3FFDzBv6JK6FOkxsjbgPWV8Q8omCkK7c_driqchdNTf_O5kqxsuqMdkMv7ybbSf95UV8lBwvchLzBXxMSjrLWsbE21sdWBBat-2trDWizK2pfOgK8aDKGBVACAVo5HSBSfkE7KZZql5Smjj0aosGAFgpOG6DI6bWFpAJs5qKTPyeq3U-vuKQKOGwAOtUN9YISO7qO9rCSS97j7M5qd170O1FtwxpRoFoEyBnX3TyuAUV6F0pXM2I-_QWjVOFrBNcP0NAxgoaqyuDIBXBbsxy8jOQBJcKgyb1_au1zOyBmyI3Hhc6oy8um7GnpimlprZspPRDAAUg7GYwTwZ_NmwJU3POlpvCLV5afiz_-75nGwJzLhhJhd8h2wu5svmBUCmhX_Z-cNvdx8Uzg
  priority: 102
  providerName: Scholars Portal
Title DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents
URI https://www.proquest.com/docview/2565480136
https://search.proquest.com/docview/2566029308
https://pubmed.ncbi.nlm.nih.gov/PMC8401971
https://doaj.org/article/621a044e41254243bef3ca414c9a9aa8
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Bb9MwFLa2ceGCgIHIGJURCC5kjWPHdo5ptzKhtaoQlXqLbCfZKlF36toD_Hrec9NtgRs5RFH8Ijl-fvb3rM-fCfnIbcabtHKxygweYcZkbEXSxFUGYB8F20SD65DjibyciW_zbH5Asv1emEDad3Zx5n8uz_ziJnArb5euv-eJ9afjISQlLFesf0gOYfp9lKLvMK-C3JzvpEg5pPR9v2UoyiI0HprDBVxSpJ15KMj1_zso_02UfDTzjJ6TZy1kpMWuai_IQe1fkuPCQ7q8_EU_0UDiDKvjx8SeTwp6bpYwSnyhPub0auWv4-EN5P90OhsV9ApJQnfU-IpOUaIBNyXjE-ozUTAarM3vBS590GG7zTvYFg_CT6_IbHTxY3gZt8coxC5jchPnSAyxlRPa6qSpVaWrRrrEcWmbRmda2zSvmtxYaKuEuTSDIQBQU1Upzo0zKX9NjvzK128IrS26MHEqBeRRM5k7w1SVa4AhRkvOI_Jh36jl7U4to4QsA71QPnghIgNs73sLVLgOL1br67L1cylTZhIhagEITKSC27rhzggmXG5yY3REPqO3SoxD8I0z7XYCqCi2WFkoQKoCpt4kIqcdS4gf1y3e-7ts4_euBCCIQniMy4i8vy_GL5GT5uvVNtjIBNBSAnVRnX7S-bNuCXTpoOHdduGT__7yLXmaIr0mUXHKTsnRZr2t3wE-2tgeRMVc9ciTwcVk-r0XVhng_nXO4D4Wuhfi5Q_ZshPV
link.rule.ids 230,314,727,780,784,864,885,2102,2221,12056,21388,24318,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793,73745,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELege4AXNBiIbAOMQPBCNDt2nOQJpd2qAl1VoVXaW-SPZOvDnNGPB_jruUvTloDEWxRfFOfOPv_ucv6ZkPfCxKKKnA2TWOMRZlyFRrIqdDGAfSRskxXmIS8najSTX6_j6zbhtmzLKrc-sXHUrraYIz-DpRmpybhQn-9_hHhqFP5dbY_QeEgOkDk97pGD_sVk-n2XZWnYbJTY8JIKiO_P_JojQ4tMRWclagj7_3XLf5dK_rH2DA_JkxY00nxj5afkQemfkaPcQ8B895N-oE0ZZ5MfPyLmfJLTc30HfuIT9aGg49rfhINbPfd0OhvmdIxlQkuqvaNTJGnAbcl4hQxNFIT6C_1rjskPOmg3ejey-Z766TmZDS-uBqOwPUghtDFXqzDD0hDjrExNyqoycamrlGVWKFNVaZymJspclWkDCmLcRjE4AcBNziVCaKsj8YL0fO3Ll4SWBo3IbBIB9ii5yqzmictSACI6VUIE5N1WqcX9hi-jgDgDVV_sVR-QPup7J4Ec182NenFTtFOmUBHXTMpSAgaTkRSmrITVkkub6UzrNCAf0VoFzkSwjdXthgLoKGqsyBPAqhIWXxaQ044kzCDbbd7au2hn8LLYj7eAvN0145NYlebLet3IKAZ4iUFfks446XxZt8XPbxsWb4iseZbw4_-__A15NLq6HBfjL5NvJ-RxhBU1LAkjfkp6q8W6fAWQaGVet-P-NwHOCe0
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELegkxAvaDAQ3QYYgeCFqHbsOMkTSttVA0pVISrtLfJHsvVh7ujHA_z13KVuS0DiLYovinNn350vP_9MyFthElHHzkZpovEIM64iI1kduQSSfSRskzXWIb9O1OVMfr5KrgL-aRVglTuf2Dhqt7BYI-9BaEZqMi5Urw6wiOlw9PHuR4QnSOGf1nCcxn1yBFGRxR1y1L-YTL_tKy4Ns40SW45SAWv9nt9wZGuRmWhFpYa8_18X_Tds8o84NDomj0ICSYutxR-Te5V_Qk4KD4vn25_0HW0gnU2t_ISY4aSgQ30LPuMD9ZGg44W_jgY3eu7pdDYq6BghQyuqvaNTJGzALcp4hWxNFIT6S_1rjoUQOgibvhvZ4kAD9ZTMRhffB5dROFQhsglX6yhHmIhxVmYmY3WVuszVyjIrlKnrLMkyE-euzrUBBTFu4wQcAuRQzqVCaKtj8Yx0_MJXzwmtDBqU2TSGPKTiKreapy7PQP06U0J0yZudUsu7LXdGCWsOVH15UH2X9FHfewnku25uLJbXZZg-pYq5ZlJWEvIxGUthqlpYLbm0uc61zrrkPVqrxFkJtrE6bC6AjqLGyiKFvFVCIGZdct6ShNlk2807e5dhNq_Kw9jrktf7ZnwSEWq-WmwaGcUgd2LQl7Q1Tlpf1m7x85uG0RtW2TxP-en_X_6KPIAhX44_Tb6ckYcxgmtYGsX8nHTWy031ArKjtXkZhv1vZtYOGg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=DNA+Damage%2C+n-3+Long-Chain+PUFA+Levels+and+Proteomic+Profile+in+Brazilian+Children+and+Adolescents&rft.jtitle=Nutrients&rft.au=de+Barros%2C+Tamiris+Trevisan&rft.au=Venancio%2C+Vinicius+de+Paula&rft.au=Hernandes%2C+L%C3%ADvia+Cristina&rft.au=Antunes%2C+Lusania+Maria+Greggi&rft.date=2021-07-21&rft.pub=MDPI&rft.eissn=2072-6643&rft.volume=13&rft.issue=8&rft_id=info:doi/10.3390%2Fnu13082483&rft_id=info%3Apmid%2F34444642&rft.externalDBID=PMC8401971
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2072-6643&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2072-6643&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2072-6643&client=summon