Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection

Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively...

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Published in	Yàowu shi͡p︡in fenxi Vol. 26; no. 3; pp. 1015 - 1023
Main Authors	Richart, Sarah M., Li, Yi-Lin, Mizushina, Yoshiyuki, Chang, Yuan-Yen, Chung, Tse-Yu, Chen, Guan-Heng, Tzen, Jason Tze-Cheng, Shia, Kak-Shan, Hsu, Wei-Li
Format	Journal Article
Language	English
Published	China (Republic : 1949- ) Elsevier B.V 01.07.2018 Food and Drug Administration Taiwan Food and Drug Administration
Subjects	AKT protein Antibiotics Antiviral Antiviral activity antiviral properties Apoptosis Avian flu Curcumin Cytotoxicity Deoxyribonucleic acid DNA DNA polymerase Drugs food colorants Food dyes Haemagglutinin Infections Influenza Influenza virus Kinases Original Orthomyxoviridae Phosphorylation Studies Synergic synergism turmeric Viruses China Taiwan Synergic Antiviral Curcumin Haemagglutinin Influenza virus
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Abstract	Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection. [Display omitted] •As with Cur, MAC effectively inhibited IAV infection.•Combination of curcumin and MAC achieved antiviral synergy.•MAC strongly dampened Akt phosphorylation, the prerequisite signalling for IAV propagation.•MAC inhibited IAV via multiple mechanisms in non-identical ways as Cur.
AbstractList	Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection. [Display omitted] •As with Cur, MAC effectively inhibited IAV infection.•Combination of curcumin and MAC achieved antiviral synergy.•MAC strongly dampened Akt phosphorylation, the prerequisite signalling for IAV propagation.•MAC inhibited IAV via multiple mechanisms in non-identical ways as Cur. Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection.
Author	Mizushina, Yoshiyuki Li, Yi-Lin Tzen, Jason Tze-Cheng Chung, Tse-Yu Chang, Yuan-Yen Chen, Guan-Heng Shia, Kak-Shan Hsu, Wei-Li Richart, Sarah M.
AuthorAffiliation	d Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, 402, Taiwan a Department of Biology and Chemistry, Azusa Pacific University, Azusa, CA, USA c Graduate School of Agriculture, Shinshu University, Kamiina-gun, Nagano, 399-4598, Japan f Institute of Biotechnology and Pharmaceutical Research, National Health Research Institute, Miaoli County, 35053, Taiwan b Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan e Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan
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Keywords	Synergic Antiviral Curcumin Haemagglutinin Influenza virus
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Snippet	Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a...
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SubjectTerms	AKT protein Antibiotics Antiviral Antiviral activity antiviral properties Apoptosis Avian flu Curcumin Cytotoxicity Deoxyribonucleic acid DNA DNA polymerase Drugs food colorants Food dyes Haemagglutinin Infections Influenza Influenza virus Kinases Original Orthomyxoviridae Phosphorylation Studies Synergic synergism turmeric Viruses
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Title	Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection
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