Effects of Tenofovir Disoproxil Fumarate in Hepatitis B e Antigen-Positive Patients With Normal Levels of Alanine Aminotransferase and High Levels of Hepatitis B Virus DNA

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 146; no. 5; pp. 1240 - 1248
• Main Authors: Chan, Henry L.Y., Chan, Chi Kuen, Hui, Aric Josun, Chan, Sing, Poordad, Fred, Chang, Ting-Tsung, Mathurin, Philippe, Flaherty, John F., Lin, Lanjia, Corsa, Amy, Gaggar, Anuj, Subramanian, G. Mani, McHutchison, John G., Lee, Sam, Gane, Edward J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2014
• Subjects: Adenine - adverse effects; Adenine - analogs & derivatives; Adenine - therapeutic use; Adolescent; Adult; Alanine Transaminase - blood; Antiviral Agents - adverse effects; Antiviral Agents - therapeutic use; Biomarkers - blood; Combination Therapy; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; DNA, Viral - blood; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; FTC; Gastroenterology and Hepatology; HBsAg; Hepatitis B e Antigens - blood; Hepatitis B virus - drug effects; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Hepatitis B, Chronic - blood; Hepatitis B, Chronic - diagnosis; Hepatitis B, Chronic - drug therapy; Humans; Immune Tolerance; Immune Tolerant; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Phosphorous Acids - adverse effects; Phosphorous Acids - therapeutic use; Time Factors; Treatment Outcome; Viral Load; Young Adult; FTC; Combination Therapy; ULN; HBeAg; TDF; pol/RT; HBsAg; ALT; HCC; Immune Tolerant; CHB; HBV; chronic hepatitis B; emtricitabine; hepatitis B surface antigen; hepatitis B virus; alanine aminotransferase; hepatitis B e antigen; upper limit of normal; tenofovir disoproxyl fumarate; polymerase/reverse transcriptase; hepatocellular carcinoma

Little is known about the benefit of antiviral therapy for hepatitis B e antigen (HBeAg)−positive patients with high viral load and normal levels of alanine aminotransferase. We evaluated the effects of single and combination therapies in immune-tolerant patients with chronic hepatitis B. In a doubl...